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    CLEC5A C-type lectin domain containing 5A [ Homo sapiens (human) ]

    Gene ID: 23601, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression.

    The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression.
    Li Q, Liu Y, Wang X, Xie C, Mei X, Cao W, Guan W, Lin X, Xie X, Zhou C, Yi E., Free PMC Article

    08/6/2024
    [Overexpression of CLEC5A inhibits cell proliferation and metastasis and reverses epithelial-mesenchymal transition in hepatocellular carcinoma].

    [Overexpression of CLEC5A inhibits cell proliferation and metastasis and reverses epithelial-mesenchymal transition in hepatocellular carcinoma].
    Lin J, Ou H, Wang W, Ma J, Zhang W, Liu Q., Free PMC Article

    03/3/2023
    CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID-19 therapy.

    CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID-19 therapy.
    Machado TL, Santos AC, Azamor T, da Silva AMV, Pimenta VR, Tubarão LN, da Silva ADS, Flores Rodrigues DDR, Müller R, Pinto MA, Villar LM, Bom APA, Melgaço JG., Free PMC Article

    01/28/2023
    CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation.

    CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation.
    Sung PS, Yang SP, Peng YC, Sun CP, Tao MH, Hsieh SL., Free PMC Article

    07/23/2022
    Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response.

    Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response.
    Tosiek MJ, Groesser K, Pekcec A, Zwirek M, Murugesan G, Borges E., Free PMC Article

    04/16/2022
    CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma.

    CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma.
    Tong L, Li J, Choi J, Pant A, Xia Y, Jackson C, Liu P, Yi L, Boussouf E, Lim M, Yang X.

    08/7/2021
    Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn's disease.

    Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn's disease.
    Elleisy N, Rohde S, Huth A, Gittel N, Glass Ä, Möller S, Lamprecht G, Schäffler H, Jaster R., Free PMC Article

    02/13/2021
    CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections.

    CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections.
    Sung PS, Hsieh SL., Free PMC Article

    11/21/2020
    CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway.

    CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway.
    Wang Q, Shi M, Sun S, Zhou Q, Ding L, Jiang C, Bian T, Jia F, Liu Y, Qin J.

    10/24/2020
    CEBPB can inhibit the proliferation of osteosarcoma cells via regulating the expression of CLEC5A.

    Transcription factor CEBPB inhibits the proliferation of osteosarcoma by regulating downstream target gene CLEC5A.
    Lu J, Chen W, Liu H, Yang H, Liu T., Free PMC Article

    04/18/2020
    REVIEW: CLEC5A, a Promiscuous Pattern Recognition Receptor to Microbes and Beyond

    CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond.
    Sung PS, Chang WC, Hsieh SL., Free PMC Article

    03/28/2020
    CLEC5A was highly upregulated in glioblastoma compared to normal brain tissues, which had an opposite relation with the overall patient survival. Downregulation of CLEC5A could inhibit cell proliferation, migration and invasion via promoting apoptosis and G1 arrest.

    C-type lectin domain family 5, member A (CLEC5A, MDL-1) promotes brain glioblastoma tumorigenesis by regulating PI3K/Akt signalling.
    Fan HW, Ni Q, Fan YN, Ma ZX, Li YB., Free PMC Article

    06/22/2019
    MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival.

    The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival.
    Xiong W, Wang H, Lu L, Xi R, Wang F, Gu G, Tao R., Free PMC Article

    08/4/2018
    this study shows association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity

    Association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity and its functional effects.
    Xavier-Carvalho C, Cezar RDDS, Freire NM, Vasconcelos CMM, Solorzano VEF, de Toledo-Pinto TG, Fialho LG, do Carmo RF, Vasconcelos LRS, Cordeiro MT, Baptista P, de Azeredo EL, da Cunha RV, de Souza LJ, Pacheco AG, Kubelka CF, Moura PMMF, Moraes MO.

    06/16/2018
    CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis

    CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis.
    Huang YL, Chen ST, Liu RS, Chen YH, Lin CY, Huang CH, Shu PY, Liao CL, Hsieh SL., Free PMC Article

    02/3/2018
    Mannose Receptor and CLEC5A on Macrophage first attracts the Dengue Virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction. Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex.

    Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex.
    Lo YL, Liou GG, Lyu JH, Hsiao M, Hsu TL, Wong CH., Free PMC Article

    06/24/2017
    The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals.

    CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo.
    Teng O, Chen ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng JT, Tu W, Bruzzone R, Peiris JSM, Hsieh SL, Yen HL., Free PMC Article

    05/20/2017
    Concordant overexpression of MDL-1 and DAP12 were correlated with increased production of proinflammatory cytokines in rheumatoid arthritis patients.

    A potential role of myeloid DAP12-associating lectin (MDL)-1 in the regulation of inflammation in rheumatoid arthritis patients.
    Chen DY, Yao L, Chen YM, Lin CC, Huang KC, Chen ST, Lan JL, Hsieh SL., Free PMC Article

    11/8/2014
    Blockade of CLEC5A inhibits NLRP3 inflammasome activation and pyrotopsis in dengue-virus-infected inflammatory macrophages. Thus, DV can activate NLRP3 inflammasome via CLEC5A.

    CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
    Wu MF, Chen ST, Yang AH, Lin WW, Lin YL, Chen NJ, Tsai IS, Li L, Hsieh SL.

    03/2/2013
    No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and Kawasaki disease patients.

    Lack of association between CLEC5A gene single-nucleotide polymorphisms and Kawasaki disease in Taiwanese children.
    Yang YL, Chang WP, Hsu YW, Chen WC, Yu HR, Liang CD, Tsai YT, Huang YH, Yang KD, Kuo HC, Chang WC., Free PMC Article

    10/6/2012
    CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4.

    Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.
    Watson AA, Lebedev AA, Hall BA, Fenton-May AE, Vagin AA, Dejnirattisai W, Felce J, Mongkolsapaya J, Palma AS, Liu Y, Feizi T, Screaton GR, Murshudov GN, O'Callaghan CA., Free PMC Article

    09/10/2011
    CLEC5A expression in monocyte/macrophage and granulocytes is regulated by PU.1.

    CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation.
    Batliner J, Mancarelli MM, Jenal M, Reddy VA, Fey MF, Torbett BE, Tschan MP., Free PMC Article

    02/5/2011
    Observational study of gene-disease association. (HuGE Navigator)

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    04/7/2010
    The crystal volume per unit weight (VM) was calculated to be 2.34 A3 Da-1, with nine molecules per asymmetric unit and a solvent content of 47.38%. CLEC5A plays an important role in the pathophysiology of dengue-virus-induced disease.

    Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.
    Watson AA, O'Callaghan CA., Free PMC Article

    03/29/2010
    blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with Dengue virus (either alone or complexed with an enhancing antibody)

    CLEC5A is critical for dengue-virus-induced lethal disease.
    Chen ST, Lin YL, Huang MT, Wu MF, Cheng SC, Lei HY, Lee CK, Chiou TW, Wong CH, Hsieh SL.

    01/21/2010
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