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    AMACR alpha-methylacyl-CoA racemase [ Homo sapiens (human) ]

    Gene ID: 23600, updated on 27-Aug-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Alpha-methyl CoA racemase (AMACR) reactivity across the spectrum of clear cell renal cell neoplasms.

    Alpha-methyl CoA racemase (AMACR) reactivity across the spectrum of clear cell renal cell neoplasms.
    Rotterova P, Alaghehbandan R, Skopal J, Rogala J, Slisarenko M, Strakova Peterikova A, Michalova K, Montiel DP, Farcas M, Ulamec M, Stransky P Jr, Fiala O, Pitra T, Hora M, Michal M, Pivovarcikova K, Hes O.

    06/17/2024
    AMACR Expression is a Potential Diagnostic Marker in Apocrine Lesions of Breast, and is Associated with High Histologic Grade and Lymph Node Metastases in Some Invasive Apocrine Breast Cancers.

    AMACR Expression is a Potential Diagnostic Marker in Apocrine Lesions of Breast, and is Associated with High Histologic Grade and Lymph Node Metastases in Some Invasive Apocrine Breast Cancers.
    Lerner G, Tang H, Singh K, Golestani R, St Claire S, Humphrey PA, Lannin D, Janostiak R, Harigopal M.

    02/11/2023
    Alpha-methylacyl-CoA racemase (AMACR) protein is upregulated in early proliferative lesions of the breast irrespective of apocrine differentiation.

    Alpha-methylacyl-CoA racemase (AMACR) protein is upregulated in early proliferative lesions of the breast irrespective of apocrine differentiation.
    Gatalica Z, Stafford P, Vranic S.

    11/26/2022
    P504S/alpha-methylacyl-CoA racemase, HNF1beta and napsin A in morular metaplasia and clear cell carcinoma of the endometrium: An immunohistochemical analysis.

    P504S/alpha-methylacyl-CoA racemase, HNF1β and napsin A in morular metaplasia and clear cell carcinoma of the endometrium: An immunohistochemical analysis.
    Arciuolo D, Travaglino A, Raffone A, Santoro A, Inzani F, Piermattei A, Bui L, Scaglione G, D'Alessandris N, Valente M, Fulgione C, Guida M, Mollo A, Insabato L, Zannoni GF.

    08/13/2022
    Oncogenic Activity of Solute Carrier Family 45 Member 2 and Alpha-Methylacyl-Coenzyme A Racemase Gene Fusion Is Mediated by Mitogen-Activated Protein Kinase.

    Oncogenic Activity of Solute Carrier Family 45 Member 2 and Alpha-Methylacyl-Coenzyme A Racemase Gene Fusion Is Mediated by Mitogen-Activated Protein Kinase.
    Zuo ZH, Yu YP, Ren BG, Liu S, Nelson J, Wang Z, Tao J, Pradhan-Sundd T, Bhargava R, Michalopoulos G, Chen Q, Zhang J, Ma D, Pennathur A, Luketich J, Satdarshan Monga P, Nalesnik M, Luo JH., Free PMC Article

    03/5/2022
    Napsin-A and AMACR are Superior to HNF-1beta in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract.

    Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract.
    Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L., Free PMC Article

    08/7/2021
    Correlation of cyclin D1, HER2, and AMACR expressions with histologic grade in bladder urothelial carcinomas.

    Correlation of cyclin D1, HER2, and AMACR expressions with histologic grade in bladder urothelial carcinomas.
    Karakaya YA, Oral E.

    07/24/2021
    Expression of alpha-methylacyl-CoA racemase in vaginal gastric-type adenocarcinoma and uterine clear cell carcinoma.

    Expression of alpha-methylacyl-CoA racemase in vaginal gastric-type adenocarcinoma and uterine clear cell carcinoma.
    Hu J, Lu Y, Tang N, Li L, Guo P, Zhang Y.

    10/24/2020
    As the mutation was found in the healthy samples as well, it can be said that the current mutation AMACR can be involved in some other forms of peripheral neuropathy which can be with other phenotypes.

    Role of Alpha-methylacyl-CoA racemase gene in pathogenecity of CMT patients.
    Kanwal S, Perveen S, Arshad HM.

    10/5/2019
    High AMACR expression is associated with prostate cancer.

    Semen AMACR protein as a novel method for detecting prostate cancer.
    Etheridge T, Straus J, Ritter MA, Jarrard DF, Huang W.

    02/2/2019
    High expression of AMACR was not only a key adverse prognostic factor but also a potential therapeutic target in oral squamous cell carcinoma

    AMACR overexpression acts as a negative prognostic factor in oral squamous cell carcinoma.
    He HL, Lee YE, Chang MT, Shiue YL, Chang SL, Chen TJ, Chiu CT., Free PMC Article

    09/22/2018
    AMACR expression was studied in normal mucosa of the colon, adenomas with different degrees of dysplasia, colonic carcinomas, lymph nodes and liver metastases of colonic carcinomas. Expression was nearly absent in samples of normal mucosa, increased in both adenomas and carcinomas, decreased in lymph node metastases but was significantly increased in liver metastases.

    [The value of alpha-methylacyl-CoA racemase expression in the progression of colonic carcinoma].
    López-Valdivia CM, González-Matea M, Mayordomo E, Hervás D, Ramos D.

    07/28/2018
    IMP3 has a similar specificity, but a better sensitivity, intensity, and extent of reactivity in comparison with AMACR, and may be used as an alternative to AMACR, in support of the diagnosis of BE-dysplasia and EAC

    IMP3 Immunoreactivity is More Sensitive Than AMACR in Detecting Dysplastic Epithelium and Early Adenocarcinoma in Barrett Esophagus.
    Gadara MR, Gonzalez M, Cartun RW, Ligato S.

    04/7/2018
    As an adjunct to biopsy, AMACR and HMWCK have value for resolving diagnostically challenging cases

    Evaluation of role of alpha-methyl acyl-coenzyme A racemase/P504S and high molecular weight cytokeratin in diagnosing prostatic lesions.
    Jain D, Gupta S, Marwah N, Kalra R, Gupta V, Gill M, Jain N, Lal S, Sen R.

    02/24/2018
    Single nucleotide polymorphism in AMACR gene is associated with schizophrenia risk loci with potential implications for neurocognitive performance.

    Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.
    Kos MZ, Carless MA, Peralta J, Curran JE, Quillen EE, Almeida M, Blackburn A, Blondell L, Roalf DR, Pogue-Geile MF, Gur RC, Göring HHH, Nimgaonkar VL, Gur RE, Almasy L., Free PMC Article

    02/17/2018
    Results show that AMACR expression is significantly high in patients with prostate cancer.

    T2E (TMPRSS2-ERG) fusion transcripts are associated with higher levels of AMACR mRNA and a subsequent prostate cancer diagnosis in patients with atypical small acinar proliferation.
    Eryilmaz IE, Kordan Y, Vuruskan BA, Kaygısız O, Tunca B, Cecener G.

    02/3/2018
    High AMACR expression is associated with prostate cancer.

    Induction of alpha-methylacyl-CoA racemase by miR-138 via up-regulation of β-catenin in prostate cancer cells.
    Erdmann K, Kaulke K, Rieger C, Wirth MP, Fuessel S.

    11/11/2017
    AMACR staining was positively expressed in 86 of the prostate carcinoma cases and completely absent in remaining 12.

    Diagnostic Value of ERG in Prostate Needle Biopsies Containing Minute Cancer Foci.
    Bachurska SY, Staykov DG, Bakardzhiev IV, Antonov PA, Belovezhdov VT.

    06/24/2017
    Data show a significant association between Alpha-methylacyl-CoA racemase (AMACR) and ERG protein with prognostic implication in prostate cancer.

    High alpha-methylacyl-CoA racemase (AMACR) is associated with ERG expression and with adverse clinical outcome in patients with localized prostate cancer.
    Box A, Alshalalfa M, Hegazy SA, Donnelly B, Bismar TA.

    02/25/2017
    AMACR is expressed in most of the chordomas but only in a minority of chondrosarcomas. AMACR may serve as IHC marker of chordoma with differentiating ability comparable to that of beta-catenin.

    α-methylacyl-CoA racemase (AMACR) expression in chordomas differentiates them from chondrosarcomas.
    Aviel-Ronen S, Zadok O, Vituri A, Nass D, Schwartz I, Avivi C, Barshack I., Free PMC Article

    12/24/2016
    AMACR transcripts were detected in all radical prostatectomy(RP)-prostate cancer and RP-Benign samples but not in non-cancerous cystoprostatectomy samples, which suggest a global increase of AMACR expression in cancerous prostates.

    Global expression of AMACR transcripts predicts risk for prostate cancer - a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate.
    Alinezhad S, Väänänen RM, Ochoa NT, Vertosick EA, Bjartell A, Boström PJ, Taimen P, Pettersson K., Free PMC Article

    10/22/2016
    AMACRwas not regulated in the white blood cells of multiple sclerosis patients

    Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE.
    Tafferner N, Barthelmes J, Eberle M, Ulshöfer T, Henke M, deBruin N, Mayer CA, Foerch C, Geisslinger G, Parnham MJ, Schiffmann S.

    08/6/2016
    study showed that 34betaE12 is the most appropriate negative marker to combine with alpha-methylacyl coenzyme A racemase as a positive marker for the diagnosis of prostate adenocarcinoma[34betaE12]

    Reliability of the 34βE12, keratin 5/6, p63, bcl-2, and AMACR in the diagnosis of prostate carcinoma.
    Boran C, Kandirali E, Yilmaz F, Serin E, Akyol M.

    02/24/2016
    The D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer. The S201L polymorphism might be linked with prostate cancer risk. no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer.

    Significant association of alpha-methylacyl-CoA racemase gene polymorphisms with susceptibility to prostate cancer: a meta-analysis.
    Chen N, Wang JR, Huang L, Yang Y, Jiang YM, Guo XJ, He YZ, Zhou YH.

    02/6/2016
    AMACR amplification is a mechanism driving increased mRNA and protein expression and conferring aggressiveness through heightened cell proliferation in gastrointestinal stromal tumors

    AMACR amplification and overexpression in primary imatinib-naïve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis.
    Li CF, Chen LT, Lan J, Chou FF, Lin CY, Chen YY, Chen TJ, Li SH, Yu SC, Fang FM, Tai HC, Huang HY., Free PMC Article

    09/26/2015
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