| Long Non-coding RNA COX10-AS1 Promotes Glioma Progression by Competitively Binding miR-1-3p to Regulate ORC6 Expression. | Long Non-coding RNA COX10-AS1 Promotes Glioma Progression by Competitively Binding miR-1-3p to Regulate ORC6 Expression.
Zhang G, Tao X, Ji BW, Gong J. | 02/29/2024 |
| Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression. | Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression.
Zhu J, Chen Q, Zeng L, Gao H, Wu T, He Y, Xu J, Pang J, Peng J, Deng Y, Han Y, Yi W., Free PMC Article | 11/1/2023 |
| DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability. | DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability.
Lin YC, Liu D, Chakraborty A, Macias V, Brister E, Sonalkar J, Shen L, Mitra J, Ha T, Kajdacsy-Balla A, Prasanth KV, Prasanth SG., Free PMC Article | 05/15/2023 |
| ORC6, a novel prognostic biomarker, correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis. | ORC6, a novel prognostic biomarker, correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis.
Lin Y, Zhang Y, Tuo Z, Gao L, Ding D, Bi L, Yu D, Lv Z, Wang J, Chen X., Free PMC Article | 04/1/2023 |
| Orc6 is a component of the replication fork and enables efficient mismatch repair. | Orc6 is a component of the replication fork and enables efficient mismatch repair.
Lin YC, Liu D, Chakraborty A, Kadyrova LY, Song YJ, Hao Q, Mitra J, Hsu RYC, Arif MK, Adusumilli S, Liao TW, Ha T, Kadyrov FA, Prasanth KV, Prasanth SG., Free PMC Article | 06/11/2022 |
| Humanized Drosophila Model of the Meier-Gorlin Syndrome Reveals Conserved and Divergent Features of the Orc6 Protein. | Humanized Drosophila Model of the Meier-Gorlin Syndrome Reveals Conserved and Divergent Features of the Orc6 Protein.
Balasov M, Akhmetova K, Chesnokov I., Free PMC Article | 07/17/2021 |
| Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA. | Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA.
Xu N, You Y, Liu C, Balasov M, Lun LT, Geng Y, Fung CP, Miao H, Tian H, Choy TT, Shi X, Fan Z, Zhou B, Akhmetova K, Din RU, Yang H, Hao Q, Qian P, Chesnokov I, Zhu G., Free PMC Article | 11/21/2020 |
| The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene. | [A boy with Meier-Gorlin syndrome carrying a novel ORC6 mutation and uniparental disomy of chromosome 16].
Li J, Ding Y, Chang G, Cheng Q, Li X, Wang J, Wang X, Shen Y. | 07/1/2017 |
| The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation. | Further insight into the phenotype associated with a mutation in the ORC6 gene, causing Meier-Gorlin syndrome 3.
Shalev SA, Khayat M, Etty DS, Elpeleg O. | 04/30/2016 |
| our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions | A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.
Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM., Free PMC Article | 04/4/2015 |
| findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process. | Different roles of the human Orc6 protein in the replication initiation process.
Thomae AW, Baltin J, Pich D, Deutsch MJ, Ravasz M, Zeller K, Gossen M, Hammerschmidt W, Schepers A. | 01/7/2012 |
| Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. | Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.
Liu S, Balasov M, Wang H, Wu L, Chesnokov IN, Liu Y., Free PMC Article | 07/16/2011 |
| In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans. | Functional analysis of an Orc6 mutant in Drosophila.
Balasov M, Huijbregts RP, Chesnokov I., Free PMC Article | 01/21/2010 |
| Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin | Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin.
Gavin EJ, Song B, Wang Y, Xi Y, Ju J., Free PMC Article | 01/21/2010 |
| Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. | Ku80 binds to human replication origins prior to the assembly of the ORC complex.
Sibani S, Price GB, Zannis-Hadjopoulos M. | 01/21/2010 |
| results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis | Orc6 involved in DNA replication, chromosome segregation, and cytokinesis.
Prasanth SG, Prasanth KV, Stillman B. | 01/21/2010 |
| Functional studies of the Drosophila homolog | Functional analysis of mutant and wild-type Drosophila origin recognition complex.
Chesnokov I, Remus D, Botchan M., Free PMC Article | 06/27/2003 |
| Functional studies of the yeast homolog | Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system.
Li JJ, Herskowitz I. | 06/27/2003 |