| Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response. | Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
Cumova A, Vymetalkova V, Opattova A, Bouskova V, Pardini B, Kopeckova K, Kozevnikovova R, Lickova K, Ambrus M, Vodickova L, Naccarati A, Soucek P, Vodicka P. | 01/15/2022 |
| Ablation of SMUG1 Reduces Cell Viability and Increases UVC-Mediated Apoptosis in Hepatocarcinoma HepG2 Cells. | Ablation of SMUG1 Reduces Cell Viability and Increases UVC-Mediated Apoptosis in Hepatocarcinoma HepG2 Cells.
An MJ, Shin GS, Lee HM, Kim JW., Free PMC Article | 07/24/2021 |
| [Comparative Analysis of the Activity of the Polymorphic Variants of Human Uracil-DNA-Glycosylases SMUG1 and MBD4]. | [Comparative Analysis of the Activity of the Polymorphic Variants of Human Uracil-DNA-Glycosylases SMUG1 and MBD4].
Alekseeva IV, Bakman AS, Iakovlev DA, Kuznetsov NA, Fedorova OS. | 04/24/2021 |
| Role of Arg243 and His239 Residues in the Recognition of Damaged Nucleotides by Human Uracil-DNA Glycosylase SMUG1. | Role of Arg243 and His239 Residues in the Recognition of Damaged Nucleotides by Human Uracil-DNA Glycosylase SMUG1.
Iakovlev DA, Alekseeva IV, Kuznetsov NA, Fedorova OS. | 02/2/2021 |
| Data shows that SMUG1 forms an extensive network of contacts with DNA involving certain amino acids. Phe98 is involved in the stacking interaction in the base-binding pocket of the active site. His239 handles the DNA backbone via a contact with a phosphate group, and Arg243 gets inserted into the void formed after Ura base flipping out from the DNA duplex and forms a network of hydrogen bonds with neighboring nucleobases. | The Role of Active-Site Residues Phe98, His239, and Arg243 in DNA Binding and in the Catalysis of Human Uracil-DNA Glycosylase SMUG1.
Iakovlev DA, Alekseeva IV, Vorobjev YN, Kuznetsov NA, Fedorova OS., Free PMC Article | 01/25/2020 |
| Exposure of DNA oligomers with deoxyuridine monophosphate incorporated at a specific site (U-DNA) to hSMUG1 causes strand cleavage at the lesion site, indicating that the enzyme incises DNA after uracil removal. | Excision of uracil from DNA by hSMUG1 includes strand incision and processing.
Alexeeva M, Moen MN, Grøsvik K, Tesfahun AN, Xu XM, Muruzábal-Lecumberri I, Olsen KM, Rasmussen A, Ruoff P, Kirpekar F, Klungland A, Bjelland S., Free PMC Article | 08/24/2019 |
| This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype. | Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness.
Korourian A, Roudi R, Shariftabrizi A, Kalantari E, Sotoodeh K, Madjd Z. | 06/9/2018 |
| Our study showed that c.-31A/G-SMUG1 genotypes/alleles do not have any association with the occurrence or severity of advanced type age-related macular degeneration (AMD). There was no interaction of CRP levels and SMUG1 genotypes in AMD susceptibility. | Association of the DNA repair SMUG1 rs3087404 polymorphism and its interaction with high sensitivity C-reactive protein for age-related macular degeneration in Iranian patients.
Bonyadi M, Mehdizadeh F, Jabbarpoor Bonyadi MH, Soheilian M, Javadzadeh A, Yaseri M. | 12/2/2017 |
| A case-control study of 801 bladder cancer patients and 801 matched controls, the associations of 167 single nucleotide polymorphisms (SNPs) from 19 genes of the BER pathway with the risk of bladder cancer; 13 SNPs in 10 Base excision repair (BER) pathway genes were significantly associated with bladder cancer risk; most significant SNP was rs2029167 in the SMUG1 gene. | Genetic variations in base excision repair pathway and risk of bladder cancer: a case-control study in the United States.
Xie H, Gong Y, Dai J, Wu X, Gu J. | 02/7/2015 |
| Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy. | Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.
Abdel-Fatah TM, Albarakati N, Bowell L, Agarwal D, Moseley P, Hawkes C, Ball G, Chan S, Ellis IO, Madhusudan S. | 07/19/2014 |
| The results obtained suggest the potential role of the g.4235T>C and the c.-31A>G polymorphisms in AMD pathogenesis. | Association between polymorphism of the DNA repair SMUG1 and UNG genes and age-related macular degeneration.
Synowiec E, Wysokinski D, Zaras M, Kolodziejska U, Stoczynska-Fidelus E, Janik K, Szaflik J, Blasiak J, Szaflik JP. | 04/19/2014 |
| There was no difference between SMUG1 proficient and depleted cells following continuous exposure. | SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.
Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD., Free PMC Article | 09/21/2013 |
| SMUG1 is a DKC1 interaction partner that contributes to rRNA quality control, partly by regulating 5-hydroxymethyluridine levels. | The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.
Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H. | 03/30/2013 |
| Data show that uracil-DNA glycosylases SMUG1 and UNG2 display widely different sequence preferences. | Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
Doseth B, Ekre C, Slupphaug G, Krokan HE, Kavli B. | 09/29/2012 |
| there was increased risk of breast cancer among postmenopausal women heterozygous for either SMUG1 rs2029166 or rs7296239. Among premenopausal women, the increased risk associated with SMUG1 rs2029166 was limited to those with low folate intake. | Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk.
Marian C, Tao M, Mason JB, Goerlitz DS, Nie J, Chanson A, Freudenheim JL, Shields PG., Free PMC Article | 12/17/2011 |
| analysis of species specific differences between mouse and humans in regulation of SMUG1 and UNG2 | Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.
Doseth B, Visnes T, Wallenius A, Ericsson I, Sarno A, Pettersen HS, Flatberg A, Catterall T, Slupphaug G, Krokan HE, Kavli B., Free PMC Article | 07/16/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesPolymorphisms in the base excision repair pathway and graft-versus-host disease.
Arora M, Lindgren B, Basu S, Nagaraj S, Gross M, Weisdorf D, Thyagarajan B. Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium. Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.
Thyagarajan B, Lindgren B, Basu S, Nagaraj S, Gross MD, Weisdorf DJ, Arora M. | 06/30/2010 |
| Properties used by hSMUG1 to select damaged pyrimidines include the size and free energy of solvation of the 5-substituent but not electronic inductive properties. | Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase.
Darwanto A, Theruvathu JA, Sowers JL, Rogstad DK, Pascal T, Goddard W 3rd, Sowers LC., Free PMC Article | 01/21/2010 |
| hSMUG1 excised fU from DNA opposite all normal bases with the highest activity when opposite non-cognate C or T followed by G and cognate A | Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1.
Knaevelsrud I, Slupphaug G, Leiros I, Matsuda A, Ruoff P, Bjelland S. | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population.
Chanson A, Parnell LD, Ciappio ED, Liu Z, Crott JW, Tucker KL, Mason JB., Free PMC Article | 05/17/2009 |
| proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity | Insights from xanthine and uracil DNA glycosylase activities of bacterial and human SMUG1: switching SMUG1 to UDG.
Mi R, Dong L, Kaulgud T, Hackett KW, Dominy BN, Cao W. | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Comprehensive analysis of DNA repair gene variants and risk of meningioma.
Bethke L, Murray A, Webb E, Schoemaker M, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Kosteljanetz M, Swerdlow A, Houlston R. | 04/3/2008 |
| The structure and specificity of SMUG1 have been solved. | Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.
Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH. | 01/21/2010 |
| hSMUG1 is a broad specificity backup for hUNG2, the major enzyme for removal of deaminated cytosine in single strnaded DNA | hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.
Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G. | 01/21/2010 |
| SMUG1 plays little natural role in antibody diversification. | SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.
Di Noia JM, Rada C, Neuberger MS., Free PMC Article | 01/21/2010 |