| Caspase-14-From Biomolecular Basics to Clinical Approach. A Review of Available Data. | Caspase-14-From Biomolecular Basics to Clinical Approach. A Review of Available Data.
Markiewicz A, Sigorski D, Markiewicz M, Owczarczyk-Saczonek A, Placek W., Free PMC Article | 06/19/2021 |
| High CASP14 expression is a marker of breast cancer aggressiveness in association with proliferation, TNBC phenotype, and cancer stemness. | Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.
Handa T, Katayama A, Yokobori T, Yamane A, Horiguchi J, Kawabata-Iwakawa R, Rokudai S, Bao P, Gombodorj N, Altan B, Kaira K, Asao T, Kuwano H, Nishiyama M, Oyama T. | 11/26/2017 |
| overexpression of S100A7 in A431 skin squamous carcinoma cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3 and caspase-14 | S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.
Li T, Qi Z, Kong F, Li Y, Wang R, Zhang W, Shang Y, Huang L, He D, Xiao X. | 04/23/2016 |
| caspase-14 contributes to retinal pigment epithelium cell barrier disruption under hyperglycemic conditions. | Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.
Beasley S, El-Sherbiny M, Megyerdi S, El-Shafey S, Choksi K, Kaddour-Djebbar I, Sheibani N, Hsu S, Al-Shabrawey M., Free PMC Article | 09/5/2015 |
| Caspase-14 was decreased in inflammatory lesions compared to non-lesion in atopic dermatitis. The amount of caspase-14 in the lesions correlated with clinical severity as determined by eczema area and severity index score and the skin barrier functions. | Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.
Jung M, Choi J, Lee SA, Kim H, Hwang J, Choi EH. | 08/8/2015 |
| Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models. | Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T., Free PMC Article | 10/11/2014 |
| partial loss of caspase 14 is not associated with dedifferentiation in neoplastic lesions of the oral mucosa | Expression of caspase 14 and filaggrin in oral squamous carcinoma.
Scharenberg C, Eckardt A, Tiede C, Kreipe H, Hussein K., Free PMC Article | 06/14/2014 |
| genetic polymorphisms in AICDA and CASP14 are associated with risk for brain tumor in Korean children. | Genetic variants of AICDA/CASP14 associated with childhood brain tumor.
Jeon S, Han S, Lee K, Choi J, Park SK, Park AK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Kim H, Ahn Y, Kang D. | 11/2/2013 |
| Suggest caspase-14 is a marker of human skin differentiation during development. | Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development.
Gkegkes ID, Aroni K, Agrogiannis G, Patsouris ES, Konstantinidou AE. | 10/26/2013 |
| Results suggest that caspase-14 may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development. | Caspase-14 suppresses GCM1 acetylation and inhibits placental cell differentiation.
Wu YH, Lo HF, Chen SH, Chen H. | 09/21/2013 |
| ceramides, an important structural lipid, stimulate caspase-14 expression, coordinating formation of lipid lamellar membranes with the formation of corneocytes | Ceramides stimulate caspase-14 expression in human keratinocytes.
Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR., Free PMC Article | 08/10/2013 |
| Caspase-14 might play a significant role in the pathogenesis of diabetic retinopathy by accelerating retinal endothelial and epithelial cells death. | Caspase-14: a novel caspase in the retina with a potential role in diabetic retinopathy.
Al-Shabrawey M, Ahmad S, Megyerdi S, Othman A, Baban B, Palenski TL, Shin ES, Gurel Z, Hsu S, Sheibani N., Free PMC Article | 12/22/2012 |
| regulation of procaspase-14 maturation during terminal differentiation is a unique two-step process involving KLK7 and an activation intermediate of caspase-14. | Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form.
Yamamoto M, Miyai M, Matsumoto Y, Tsuboi R, Hibino T., Free PMC Article | 12/8/2012 |
| genetic polynorphism is associated with the risk of childhood leukemia | Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia.
Park C, Han S, Lee KM, Choi JY, Song N, Jeon S, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Kang D. | 10/20/2012 |
| A strong association was evident between GATA-3 and caspase-14 expression in preinvasive ductal carcinoma in situ samples, where GATA-3 also displayed prognostic significance | Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.
Asselin-Labat ML, Sutherland KD, Vaillant F, Gyorki DE, Wu D, Holroyd S, Breslin K, Ward T, Shi W, Bath ML, Deb S, Fox SB, Smyth GK, Lindeman GJ, Visvader JE., Free PMC Article | 12/24/2011 |
| Regulation of caspase 14 levels provides a possible link between impaired skin barrier function and inflammatory reactions in skin diseases such as atopic dermatitis and may offer an explanation to the skin barrier dysfunction in inflamed skin lesions. | Regulation of caspase 14 expression in keratinocytes by inflammatory cytokines--a possible link between reduced skin barrier function and inflammation?
Hvid M, Johansen C, Deleuran B, Kemp K, Deleuran M, Vestergaard C. | 12/10/2011 |
| Casp-14 overexpression correlated with tumor stage, cell differentiation and lymphovascular involvement, suggesting that casp-14 was associated with tumor cell growth and metastatic potential. | Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas.
Fang HY, Chen CY, Hung MF, Hsiao YT, Chiang TC, Lin TY, Chang HW, Chow KC, Ko WJ. | 11/5/2011 |
| Caspase 14 is a cysteine protease and is inhibited by full-length LEKTI and 5 recombinant fragments of LEKTI to varied extents. | New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI.
Bennett K, Callard R, Heywood W, Harper J, Jayakumar A, Clayman GL, Di WL, Mills K. | 12/11/2010 |
| Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody | Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody.
Hibino T, Fujita E, Tsuji Y, Nakanishi J, Iwaki H, Katagiri C, Momoi T. | 05/31/2010 |
| Results imply that caspase-14 inhibits trophoblast differentiation. | Function of caspase-14 in trophoblast differentiation.
White LJ, Declercq W, Arfuso F, Charles AK, Dharmarajan AM., Free PMC Article | 01/21/2010 |
| Expression of caspase 6 and caspase 14 genes were different between normal skin of keloid-prone individuals and normal skin of keloid-resistant patients. | Gene expression profiling reveals alteration of caspase 6 and 14 transcripts in normal skin of keloid-prone patients.
Nassiri M, Woolery-Lloyd H, Ramos S, Jacob SE, Gugic D, Viciana A, Romanelli P, Elgart G, Berman B, Vincek V. | 01/21/2010 |
| These data reveal the basic organization of the human caspase-14 promoter and suggest an important role of AP-1 and NFkappaB in the transcriptional control of caspase-14. | Transcription of the caspase-14 gene in human epidermal keratinocytes requires AP-1 and NFkappaB.
Ballaun C, Karner S, Mrass P, Mildner M, Buchberger M, Bach J, Ban J, Harant H, Tschachler E, Eckhart L. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesMutational analysis of caspase genes in prostate carcinomas.
Kim MS, Park SW, Kim YR, Lee JY, Lim HW, Song SY, Yoo NJ, Lee SH. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q. Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR. Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies.
Lan Q, Morton LM, Armstrong B, Hartge P, Menashe I, Zheng T, Purdue MP, Cerhan JR, Zhang Y, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Schenk M, Zahm SH, Chatterjee N, Chanock SJ, Rothman N, Wang SS. Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors.
Kim YR, Kim KM, Yoo NJ, Lee SH. Mutational analysis of caspase-14 gene in common carcinomas.
Yoo NJ, Soung YH, Lee SH, Jeong EG, Lee SH, Yoo NJ, Soung YH, Lee SH, Jeong EG, Lee SH. | 03/13/2008 |
| caspase-14 gene is rarely mutated in colorectal carcinomas, but not mutated in gastric, lung, breast and hepatocellular carcinomas | Mutational analysis of caspase-14 gene in common carcinomas.
Yoo NJ, Soung YH, Lee SH, Jeong EG, Lee SH, Yoo NJ, Soung YH, Lee SH, Jeong EG, Lee SH. | 01/21/2010 |
| caspase-14 is aberrantly expressed in epithelial tumors | Aberrant expression of caspase-14 in epithelial tumors.
Koenig U, Sommergruber W, Lippens S. | 01/21/2010 |