| Molecular Dynamics-Ensemble Docking and Biophysical Studies for Structure-Based Identification of Non-Amino Acidic Ligands of DDAH-1. | Molecular Dynamics-Ensemble Docking and Biophysical Studies for Structure-Based Identification of Non-Amino Acidic Ligands of DDAH-1.
Bigiotti C, Bianconi E, Ruta L, Grottelli S, Coletti A, Dindo M, Carotti A, Cellini B, Macchiarulo A. | 09/17/2024 |
| Dimethylarginine Dimethylaminohydrolase - 1 expression is increased under tBHP-induced oxidative stress regulates nitric oxide production in PCa cells attenuates mitochondrial ROS-mediated apoptosis. | Dimethylarginine Dimethylaminohydrolase - 1 expression is increased under tBHP-induced oxidative stress regulates nitric oxide production in PCa cells attenuates mitochondrial ROS-mediated apoptosis.
Asha Parveen SM, Kami Reddy KR, Ummanni R. | 10/2/2023 |
| Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. | Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans.
Gautam Y, Caldwell J, Kottyan L, Chehade M, Dellon ES, Rothenberg ME, Mersha TB, Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) investigators., Free PMC Article | 05/22/2023 |
| LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway. | LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
Wu M, Li T, Li G, Niu B, Wu T, Yan L, Wang S, He S, Huang C, Tong W, Li N, Jiang J. | 05/22/2023 |
| The effect of haptoglobin genotype on the association of asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic macroangiopathy. | The effect of haptoglobin genotype on the association of asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic macroangiopathy.
Wang S, Deng Z, Zhang H, Zhang R, Yan D, Zheng X, Jia W, Hu C., Free PMC Article | 12/17/2022 |
| Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods. | Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods.
Kozlova AA, Vaganova AN, Rodionov RN, Gainetdinov RR, Bernhardt N., Free PMC Article | 10/22/2022 |
| On the kinetic mechanism of dimethylarginine dimethylaminohydrolase. | On the kinetic mechanism of dimethylarginine dimethylaminohydrolase.
Johnson CM, Fast W. | 06/11/2022 |
| Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats. | Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats.
Mei X, Zeng J, Liu DF, Zhao Y, Yang HL, Li Y, Qiu P, Tang MW. | 06/26/2021 |
| DDAH1 promoter -396 4N insertion variant is associated with increased risk of type 2 diabetes in a gender-dependent manner. | DDAH1 promoter -396 4N insertion variant is associated with increased risk of type 2 diabetes in a gender-dependent manner.
Zhu F, Zhou C, Wen Z, Wang DW., Free PMC Article | 04/3/2021 |
| Serum asymmetric-dimethylarginine, apelin and NT-pro BNP levels in dialysis patients. | Serum asymmetric-dimethylarginine, apelin and NT-pro BNP levels in dialysis patients.
Bentli R, Taskapan H, Taskapan MC, Dogan A. | 12/5/2020 |
| Long non-coding RNA H19 confers resistance to gefitinib via miR-148b-3p/DDAH1 axis in lung adenocarcinoma. | Long non-coding RNA H19 confers resistance to gefitinib via miR-148b-3p/DDAH1 axis in lung adenocarcinoma.
Huang Z, Ma Y, Zhang P, Si J, Xiong Y, Yang Y. | 10/24/2020 |
| Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients. | Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.
Wu CC, Hsieh MY, Lee CK, Chuang SY, Chung MY, Lin CC. | 09/26/2020 |
| The oncogenic function of circ-EZH2 was partly dependent on its modulation of DDAH1 and CBX3. | Circ-EZH2 knockdown reverses DDAH1 and CBX3-mediated cell growth and invasion in glioma through miR-1265 sponge activity.
Gao F, Du Y, Zhang Y, Ren D, Xu J, Chen D. | 01/11/2020 |
| DDAH1 is an important mediator of PCa progression and NO/DDAH pathway needs to be considered in developing therapeutic strategies targeted at PCa. | Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is frequently upregulated in prostate cancer, and its overexpression conveys tumor growth and angiogenesis by metabolizing asymmetric dimethylarginine (ADMA).
Reddy KRK, Dasari C, Duscharla D, Supriya B, Ram NS, Surekha MV, Kumar JM, Ummanni R. | 10/26/2019 |
| High DDAH1 expression is associated with breast cancer cell migration and vasculogenic mimicry. | MiR-193b regulates breast cancer cell migration and vasculogenic mimicry by targeting dimethylarginine dimethylaminohydrolase 1.
Hulin JA, Tommasi S, Elliot D, Hu DG, Lewis BC, Mangoni AA., Free PMC Article | 07/27/2019 |
| In a parallel experiment, the genotype of eight polymorphisms of the DDAH1 gene was also determined (Additional file 1: Table S5). Genotyping was undertaken using a proprietary competitive allele-specific PCR technique known as Kompetitive Allele Specific (KASP) PCR genotyping system which has been extensively used for uniplex SNP analysis | Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity.
Lambden S, Tomlinson J, Piper S, Gordon AC, Leiper J., Free PMC Article | 06/22/2019 |
| DDAH1 rs997251 TC + CC genotypes were associated with 2.3-fold higher risk of coronary artery disease than TT genotype (p = 0.0063). DDAH1 rs997251 CC genotype was associated with the highest ADMA. | AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
Amir M, Hassanein SI, Abdel Rahman MF, Gad MZ. | 04/27/2019 |
| MiR-21-mediated DDAH1/ADMA/NO signal pathway. | Dihydromyricetin Attenuates TNF-α-Induced Endothelial Dysfunction through miR-21-Mediated DDAH1/ADMA/NO Signal Pathway.
Yang D, Tan S, Yang Z, Jiang P, Qin C, Yuan Q, Dang R, Yao X, Qu J, Lu Q, Xu P, Zhang B, Xiang D, Chen L., Free PMC Article | 09/22/2018 |
| DDAH-1 expression is associated with promotion of angiogenesis stimulating factor VEGF. | A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1.
Buijs N, Oosterink JE, Jessup M, Schierbeek H, Stolz DB, Houdijk AP, Geller DA, van Leeuwen PA., Free PMC Article | 06/23/2018 |
| These findings suggest that DDAH1 functions as a tumor suppressor in gastric cancer (GC) and may be exploited as a diagnostic and prognostic biomarker for GC. | DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway.
Ye J, Xu J, Li Y, Huang Q, Huang J, Wang J, Zhong W, Lin X, Chen W, Lin X., Free PMC Article | 06/2/2018 |
| Data demonstrate that DDAH1 deficiency promotes the epithelial to mesenchymal transition in renal proximal tubular epithelial cells and causes fibrosis, and oxidative stress in aging and diabetic kidneys. The study provides the first direct evidence that the DDAH1 has a marked effect on kidney fibrosis and oxidative stress induced by aging or diabetes. | Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Shi L, Zhao C, Wang H, Lei T, Liu S, Cao J, Lu Z. | 03/10/2018 |
| Results confirmed DDAH1 3'-UTR as a target for miR-21, and endogenous miR-21 showed increased inhibitory effect on DDAH1-V3 transcript. | DDAH1-V3 transcript might act as miR-21 sponge to maintain balance of DDAH1-V1 in cultured HUVECs.
Kuang DB, Zhou JP, Yu LY, Zeng WJ, Xiao J, Zhu GZ, Zhang ZL, Chen XP. | 12/30/2017 |
| Inflammatory factors expressed in response to myocardial ischemia contributed to up-regulation of DDAH1. | Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression.
Zhang P, Fassett JT, Zhu G, Li J, Hu X, Xu X, Chen Y, Bache RJ. | 09/9/2017 |
| DDAH1 plays dual roles in a particular matter-induced cell death in alveolar epithelial cells. | DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells.
Wang H, Guo Y, Liu L, Guan L, Wang T, Zhang L, Wang Y, Cao J, Ding W, Zhang F, Lu Z. | 06/3/2017 |
| rs3087894 in DDAH1 was significantly associated with hypertension and showed conflicting results in different ethnic groups. This is therefore a candidate for further studies with the aim of helping to ascertain the mechanisms of hypertension in different populations. | Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China.
Wang Z, Chen S, Zhang L, Lu G, Zhou C, Wang DW, Wang L, Badengmu B, Zhai Z, Qin L., Free PMC Article | 05/6/2017 |