| RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes. | RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes.
Yu L, Jiang L, Wu M, Dou W, Ji K, Zhou J, Kim J, Xu Y., Free PMC Article | 04/5/2023 |
| MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing. | MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing.
Miyao S, Saito K, Oshima R, Kawahara K, Nagahama M. | 12/10/2022 |
| Mtr4 RNA helicase structures and interactions. | Mtr4 RNA helicase structures and interactions.
Olsen KJ, Johnson SJ., Free PMC Article | 11/6/2021 |
| Interactome analysis of the Tudor domain-containing protein SPF30 which associates with the MTR4-exosome RNA-decay machinery under the regulation of AAA-ATPase NVL2. | Interactome analysis of the Tudor domain-containing protein SPF30 which associates with the MTR4-exosome RNA-decay machinery under the regulation of AAA-ATPase NVL2.
Ishida YI, Miyao S, Saito M, Hiraishi N, Nagahama M. | 09/25/2021 |
| Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation. | Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.
Sun X, Kawata K, Miki A, Wada Y, Nagahama M, Takaya A, Akimitsu N. | 07/10/2021 |
| Mapping domains of ARS2 critical for its RNA decay capacity. | Mapping domains of ARS2 critical for its RNA decay capacity.
Melko M, Winczura K, Rouvière JO, Oborská-Oplová M, Andersen PK, Heick Jensen T., Free PMC Article | 09/12/2020 |
| MTR4 is required for the tumorigenesis of the hepatocellular carcinoma cells.MTR4 is a mediator of the functions of c-Myc in cancer metabolism.MTR4 drives cancer metabolism by ensuring correct alternative splicing of pre-mRNAs of critical glycolytic genes such as GLUT1 and PKM2. | MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing.
Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji KY, Tang Q, Chen W, Mai T, Dou W, Zhou J, Xiang LY, He YF, Yang D, Li Q, Fu X, Xu Y., Free PMC Article | 05/16/2020 |
| Data show that the nuclear exosome adaptors nuclear valosin-containing protein-like (NVL) and zinc finger, CCHC domain containing 8 protein (ZCCHC8) bind the Mtr4 exosome RNA helicase (MTR4) KOW domain on a surface. | The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
Lingaraju M, Johnsen D, Schlundt A, Langer LM, Basquin J, Sattler M, Heick Jensen T, Falk S, Conti E., Free PMC Article | 01/4/2020 |
| NRDE2 interacts with MTR4's key residues, locks MTR4 in a closed conformation, and inhibits MTR4 interaction with the exosome as well as proteins important for MTR4 recruitment | NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Wang J, Chen J, Wu G, Zhang H, Du X, Chen S, Zhang L, Wang K, Fan J, Gao S, Wu X, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y, Li J, Yun C, Cheng H., Free PMC Article | 07/6/2019 |
| The cryo-EM structure of the holo-complex shows how obligate nuclear cofactors position the hMTR4 helicase at the entrance of the core complex, suggesting a striking structural conservation from lower to higher eukaryotes. | Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
Gerlach P, Schuller JM, Bonneau F, Basquin J, Reichelt P, Falk S, Conti E., Free PMC Article | 12/22/2018 |
| a critical role for Mtr4/ZFC3H1 in nuclear surveillance of naturally unstable lncRNAs to prevent their accumulation, transport to the cytoplasm, and resultant disruption of protein synthesis | An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression.
Ogami K, Richard P, Chen Y, Hoque M, Li W, Moresco JJ, Yates JR 3rd, Tian B, Manley JL., Free PMC Article | 09/1/2018 |
| The competition between hMTR4 and ALYREF determines exosome recruitment and functions in creating balanced nuclear RNA pools for degradation and export. | Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export.
Fan J, Kuai B, Wu G, Wu X, Chi B, Wang L, Wang K, Shi Z, Zhang H, Chen S, He Z, Wang S, Zhou Z, Li G, Cheng H., Free PMC Article | 10/14/2017 |
| The described is the mRNA degradation poly(A) tail exosome targeting (PAXT) connection, which comprises the ZFC3H1 Zn-knuckle protein as a central link between MTR4 and the nuclear poly(A)-binding protein PABPN1. | Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.
Meola N, Domanski M, Karadoulama E, Chen Y, Gentil C, Pultz D, Vitting-Seerup K, Lykke-Andersen S, Andersen JS, Sandelin A, Jensen TH. | 09/2/2017 |
| We analyzed the interactions of the human TRAMP-like proteins, PAPD5, ZCCHC7, and MTR4, with the nuclear exosome. PAPD5 and ZCCHC7 exhibited mutual interactions in presence of the exosome catalytic subunit RRP6, whereas MTR4 was dispensable for their assembly | Interaction properties of human TRAMP-like proteins and their role in pre-rRNA 5'ETS turnover.
Sudo H, Nozaki A, Uno H, Ishida Y, Nagahama M. | 05/7/2017 |
| results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis | AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74.
Hiraishi N, Ishida Y, Nagahama M. | 02/20/2016 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus.
Lee HS, Lee AT, Criswell LA, Seldin MF, Amos CI, Carulli JP, Navarrete C, Remmers EF, Kastner DL, Plenge RM, Li W, Gregersen PK., Free PMC Article | 04/3/2008 |
| Results are consistent with a role for KIAA052/hMtr4p in the recruitment of the exosome to pre-rRNA to mediate the 3' end processing of the 5.8S rRNA. | C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing.
Schilders G, van Dijk E, Pruijn GJ., Free PMC Article | 01/21/2010 |
| Nuclear VCP/p97-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone. | The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1.
Nagahama M, Yamazoe T, Hara Y, Tani K, Tsuji A, Tagaya M. | 01/21/2010 |