| microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation. | microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.
Chen Y, Liu F, Chen X, Li W, Li K, Cai H, Wang S, Wang H, Xu K, Zhang C, Ye S, Shen Y, Mou T, Cai S, Zhou J, Yu J., Free PMC Article | 01/17/2024 |
| Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele. | Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.
Hussain N, Malik S, Faiz T, Shafqat F, Khan AA, Haq TU, Ali W, Aziz T, Alharbi M, Alshammari A, Alasmari AF. | 12/27/2023 |
| FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis. | FOLR2+ Macrophages Are Associated with T-cell Infiltration and Improved Prognosis.
| 06/11/2022 |
| Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.", trans "FOLR1FOLR2. | Association of periconceptional folate supplements and FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart disease in offspring: A hospital-based case-control study.
Song X, Huang P, Wang T, Zhang S, Chen L, Qin J., Free PMC Article | 05/21/2022 |
| Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids. | Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.
Warmink K, Siebelt M, Low PS, Riemers FM, Wang B, Plomp SGM, Tryfonidou MA, van Weeren PR, Weinans H, Korthagen NM., Free PMC Article | 05/7/2022 |
| Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis. | Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.
Steinz MM, Ezdoglian A, Khodadust F, Molthoff CFM, Srinivasarao M, Low PS, Zwezerijnen GJC, Yaqub M, Beaino W, Windhorst AD, Tas SW, Jansen G, van der Laken CJ., Free PMC Article | 04/2/2022 |
| Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes. | Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes.
Lu YJ, Wheeler LW 2nd, Chu H, Kleindl PJ, Pugh M, You F, Rao S, Garcia G, Wu HY, da Cunha AP, Johnson R, Westrick E, Cross V, Lloyd A, Dircksen C, Klein PJ, Vlahov IR, Low PS, Leamon CP., Free PMC Article | 03/5/2022 |
| Targeting folate receptor beta positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex. | Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex.
Tie Y, Zheng H, He Z, Yang J, Shao B, Liu L, Luo M, Yuan X, Liu Y, Zhang X, Li H, Wu M, Wei X., Free PMC Article | 10/9/2021 |
| Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy. | Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy.
Roy AG, Robinson JM, Sharma P, Rodriguez-Garcia A, Poussin MA, Nickerson-Nutter C, Powell DJ Jr., Free PMC Article | 06/19/2021 |
| Folate Receptor beta (FRbeta) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1. | Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1.
Samaniego R, Domínguez-Soto Á, Ratnam M, Matsuyama T, Sánchez-Mateos P, Corbí ÁL, Puig-Kröger A., Free PMC Article | 03/20/2021 |
| (18)F-AzaFol for Detection of Folate Receptor-beta Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study. | (18)F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study.
Schniering J, Benešová M, Brunner M, Haller S, Cohrs S, Frauenfelder T, Vrugt B, Feghali-Bostwick C, Schibli R, Distler O, Müller C, Maurer B., Free PMC Article | 11/21/2020 |
| we identified and characterised oncogenic fusion genes and their function in CRC, and implicated NAGLU-IKZF3 and RNF121-FOLR2 as novel molecular targets for personalised medicine development. | Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer.
Choi Y, Kwon CH, Lee SJ, Park J, Shin JY, Park DY., Free PMC Article | 08/17/2019 |
| Study report the expression of both FR-alpha and FR-beta on CD138 + plasma cells isolated from patients with multiple myeloma and the up-regulation of both FR-alpha and FR-beta expression after exposure to all-trans retinoic acid in two model myeloma cell lines. | Expression of functional folate receptors in multiple myeloma.
Zhou Y, Unno K, Hyjek E, Liu H, Zimmerman T, Karmakar S, Putt KS, Shen J, Low PS, Wickrema A. | 06/29/2019 |
| Folate receptor beta is expressed on myeloid cells and activated macrophages. FRbeta represents a useful marker for rheumatoid arthritis disease. [review] | The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis.
Chandrupatla DMSH, Molthoff CFM, Lammertsma AA, van der Laken CJ, Jansen G., Free PMC Article | 06/23/2019 |
| Silencing of the expression of the FOLR2 gene in NCI-H1650 cells reduced cell viability, increased cell apoptosis, and arrested cells in the G1 phase of the cell cycle, decreased the expression of cyclin D1, upregulated expression of cell cycle inhibitors, p21 and p27, upregulated the expression of Bax/Bcl-2, and inhibited phosphorylation of AKT, mTOR, and S6K1. | Silencing the FOLR2 Gene Inhibits Cell Proliferation and Increases Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via Inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 Kinase 1 (S6K1) Signaling.
Xu X, Jiang J, Yao L, Ji B., Free PMC Article | 01/26/2019 |
| We identified eight novel variants in SLC19A1 and twelve novel variants in FOLR1, FOLR2, and FOLR3. Pathogenic variants include c.1265delG in SLC19A1 resulting in an early stop codon, four large insertion deletion variants in FOLR3, and a stop_gain variant in FOLR3 | Mutations in folate transporter genes and risk for human myelomeningocele.
Findley TO, Tenpenny JC, O'Byrne MR, Morrison AC, Hixson JE, Northrup H, Au KS., Free PMC Article | 06/9/2018 |
| Folate receptor beta as a novel CD11b/CD18 regulator for trafficking and homing of a subset of macrophages on collagen. | Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.
Machacek C, Supper V, Leksa V, Mitulovic G, Spittler A, Drbal K, Suchanek M, Ohradanova-Repic A, Stockinger H. | 08/12/2017 |
| we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1, FOLR2, CD68 and CD11b markers | Expression of folate receptors alpha and beta in normal and cancerous gynecologic tissues: correlation of expression of the beta isoform with macrophage markers.
O'Shannessy DJ, Somers EB, Wang LC, Wang H, Hsu R., Free PMC Article | 08/27/2016 |
| FR-beta expression was low or absent in the majority of ovarian, breast and colorectal tumor samples. | Folate Receptor-Beta Has Limited Value for Fluorescent Imaging in Ovarian, Breast and Colorectal Cancer.
de Boer E, Crane LM, van Oosten M, van der Vegt B, van der Sluis T, Kooijman P, Low PS, van der Zee AG, Arts HJ, van Dam GM, Bart J., Free PMC Article | 05/7/2016 |
| FR-beta is uniquely expressed on this proinflammatory subpopulation offers a new strategy to suppress migration of inflammatory monocytes into sites of inflammation. | Folate receptor-β constitutes a marker for human proinflammatory monocytes.
Shen J, Hilgenbrink AR, Xia W, Feng Y, Dimitrov DS, Lockwood MB, Amato RJ, Low PS., Free PMC Article | 11/29/2014 |
| The FRalpha gene was expressed in all parathyroid cells analyzed, and the FRbeta gene was expressed by most. | Expression of functional folate receptors by human parathyroid cells.
Weber CJ, Müller S, Safley SA, Gordon KB, Amancha P, Villinger F, Camp VM, Lipowska M, Sharma J, Müller C, Schibli R, Low PS, Leamon CP, Halkar RK. | 01/25/2014 |
| High FOLR2 mRNA expression is associated with uraemic patients on hemodialysis. | Altered folate receptor 2 expression in uraemic patients on haemodialysis: implications for folate resistance.
Perna AF, Lanza D, Sepe I, Conzo G, Altucci L, Ingrosso D. | 12/14/2013 |
| severe pre-eclampsia is associated with decreased placental expression of FR-beta and a reduction in the number of fetal macrophages (Hofbauer cells) | Decreased levels of folate receptor-β and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia.
Tang Z, Buhimschi IA, Buhimschi CS, Tadesse S, Norwitz E, Niven-Fairchild T, Huang ST, Guller S., Free PMC Article | 11/23/2013 |
| Expression of folate receptor-beta on activated macrophages holds a promising potential for early diagnosis of atherosclerosis. (Review) | Macrophage folate receptor-β (FR-β) expression in auto-immune inflammatory rheumatic diseases: a forthcoming marker for cardiovascular risk?
Jager NA, Teteloshvili N, Zeebregts CJ, Westra J, Bijl M. | 03/9/2013 |
| High Folate Receptor beta expressing tumor-associated macrophages are associated with pancreatic cancer. | Clinical significance of folate receptor β-expressing tumor-associated macrophages in pancreatic cancer.
Kurahara H, Takao S, Kuwahata T, Nagai T, Ding Q, Maeda K, Shinchi H, Mataki Y, Maemura K, Matsuyama T, Natsugoe S. | 10/27/2012 |