| CBX7 promotes choroidal neovascularization by activating the HIF-1alpha/VEGF pathway in choroidal vascular endothelial cells. | CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells.
Wang Q, Zhu M, Li W, Guo Y, Lou H, Zhang J, Xu Y, Zeng B, Wen X, Ji X, Xie L. | 09/19/2024 |
| A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth. | A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.
Qiu CJ, Hu LY, Yang J, Cao JJ, Pei BG, Dai RR, Pan SJ. | 08/21/2024 |
| CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis. | CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis.
Cheng H, Hua L, Tang H, Bao Z, Xu X, Zhu H, Wang S, Jiapaer Z, Bhatia R, Dunn IF, Deng J, Wang D, Sun S, Luan S, Ji J, Xie Q, Yang X, Lei J, Li G, Wang X, Gong Y., Free PMC Article | 07/8/2024 |
| Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes. | Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes.
Park S, Choi J, Song JK, Jang B, Maeng YH. | 02/28/2024 |
| Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells. | Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells.
Zhang Y, Tedja R, Millman M, Wong T, Fox A, Chehade H, Gershater M, Adzibolosu N, Gogoi R, Anderson M, Rutherford T, Zhang Z, Chopp M, Mor G, Alvero AB., Free PMC Article | 12/6/2023 |
| Expression and correlation analysis of Skp2 and CBX7 in cervical cancer. | Expression and correlation analysis of Skp2 and CBX7 in cervical cancer.
Maimaitirexiati G, Tian P, Maimaiti H, Ding L, Ma C, Li Y, Wang J, Yan Q, Li R. | 11/26/2022 |
| CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer. | CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.
Ren W, Ren J, Zhang N, Liu X, Deng Y, Jiang Y, Yan B, Xiao X, Yu H. | 06/11/2022 |
| Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer. | Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer.
Iqbal MA, Siddiqui S, Ur Rehman A, Siddiqui FA, Singh P, Kumar B, Saluja D., Free PMC Article | 04/2/2022 |
| CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling. | CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling.
Huang Z, Yan Y, Zhu Z, Liu J, He X, Dalangood S, Li M, Tan M, Cai J, Tang P, Huang R, Shen B, Yan J., Free PMC Article | 09/25/2021 |
| MicroRNA-18a suppresses ovarian carcinoma progression by targeting CBX7 and regulating ERK/MAPK signaling pathway and epithelial-to-mesenchymal transition. | MicroRNA-18a suppresses ovarian carcinoma progression by targeting CBX7 and regulating ERK/MAPK signaling pathway and epithelial-to-mesenchymal transition.
Zhao Y, Liu XL, Huang JH, Yin AJ, Zhang H. | 04/3/2021 |
| CBX7 binds the E-box to inhibit TWIST-1 function and inhibit tumorigenicity and metastatic potential. | CBX7 binds the E-box to inhibit TWIST-1 function and inhibit tumorigenicity and metastatic potential.
Li J, Alvero AB, Nuti S, Tedja R, Roberts CM, Pitruzzello M, Li Y, Xiao Q, Zhang S, Gan Y, Wu X, Mor G, Yin G., Free PMC Article | 11/28/2020 |
| Mass spectrometry analysis revealed several non-histone protein interactions between CBX7 and the H3K9 methyltransferases SETDB1, EHMT1, and EHMT2. These CBX7-binding proteins possess a trimethylated lysine peptide motif highly similar to the canonical CBX7 target H3K27me3. | CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.
Jung J, Buisman SC, Weersing E, Dethmers-Ausema A, Zwart E, Schepers H, Dekker MR, Lazare SS, Hammerl F, Skokova Y, Kooistra SM, Klauke K, Poot RA, Bystrykh LV, de Haan G. | 04/25/2020 |
| findings suggest that CBX4 rs2289728 and CBX7 rs139394 are protective SNPs against HCC. The two SNPs may reduce the risk of HCC while suppressing the expression of CBX4 and CBX7. | Single Nucleotide Polymorphisms of CBX4 and CBX7 Decrease the Risk of Hepatocellular Carcinoma.
Tan C, Bei C, Zhu X, Zhang Y, Qin L, Tan S., Free PMC Article | 12/14/2019 |
| Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model has been demonstrated. | Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model.
Fan JR, Lee HT, Lee W, Lin CH, Hsu CY, Hsieh CH, Shyu WC., Free PMC Article | 11/30/2019 |
| CBX7 positively regulates stem cell-like characteristics of gastric cancer cells by inhibiting p16 and activating AKT-NF-kappaB-miR-21 pathway. | CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways.
Ni SJ, Zhao LQ, Wang XF, Wu ZH, Hua RX, Wan CH, Zhang JY, Zhang XW, Huang MZ, Gan L, Sun HL, Dimri GP, Guo WJ., Free PMC Article | 10/26/2019 |
| CBX7 and PRMT1 contribute to regulate E-cadherin expression through several mechanisms. | The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration.
Federico A, Sepe R, Cozzolino F, Piccolo C, Iannone C, Iacobucci I, Pucci P, Monti M, Fusco A. | 08/31/2019 |
| Decreased CBX7 expression levels were correlated with liver cirrhosis in HCC patients. Furthermore, the survival times of HCC patients who were CBX7-expression-negative were shorter than HCC patients who were CBX7-expression-positive. Results show that downregulation of CBX7 is related to HCC progression and a poor prognosis in HCC patients. | Downregulated Expression of Chromobox Homolog 7 in Hepatocellular Carcinoma.
Zhu X, Qin M, Li C, Zeng W, Bei C, Tan C, Zhang Y, Shi W, Kong J, Fu Y, Tan S. | 06/8/2019 |
| Study found that Cbx7 was downregulated in glioma cell lines and tumors and identifies it as an inhibitor of glioma cell migration through its inhibitory effect on YAP/TAZ-CTGF-hippo signaling axis and underscores the importance of epigenetic inactivation of Cbx7 in gliomagenesis. | Cbx7 is epigenetically silenced in glioblastoma and inhibits cell migration by targeting YAP/TAZ-dependent transcription.
Nawaz Z, Patil V, Arora A, Hegde AS, Arivazhagan A, Santosh V, Somasundaram K., Free PMC Article | 04/28/2018 |
| CBX7 inhibits epithelial-to-mesenchymal transformation and invasion in glioma | CBX7 negatively regulates migration and invasion in glioma via Wnt/β-catenin pathway inactivation.
Bao Z, Xu X, Liu Y, Chao H, Lin C, Li Z, You Y, Liu N, Ji J., Free PMC Article | 04/21/2018 |
| our results validate the assumption that CBX7 is a tumor suppressor of gliomas. Moreover, CBX7 is a potential and novel prognostic biomarker in glioma patients. We also clarified that CBX7 silences CCNE1 via the combination of CCNE1 promoter and the recruitment of HDAC2. | CBX7 is a glioma prognostic marker and induces G1/S arrest via the silencing of CCNE1.
Yu T, Wu Y, Hu Q, Zhang J, Nie E, Wu W, Wang X, Wang Y, Liu N., Free PMC Article | 03/10/2018 |
| Suggest CBX7 is an important tumor suppressor that negatively modulates PTEN/Akt signaling during pancreatic tumorigenesis. | CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer.
Ni S, Wang H, Zhu X, Wan C, Xu J, Lu C, Xiao L, He J, Jiang C, Wang W, He Z., Free PMC Article | 03/3/2018 |
| Data suggest that miR-375 leads to the activation of oncogenic signatures and tumor progression by targeting chromobox homolog 7 protein (CBX7). | Ago-RIP-Seq identifies Polycomb repressive complex I member CBX7 as a major target of miR-375 in prostate cancer progression.
Pickl JM, Tichy D, Kuryshev VY, Tolstov Y, Falkenstein M, Schüler J, Reidenbach D, Hotz-Wagenblatt A, Kristiansen G, Roth W, Hadaschik B, Hohenfellner M, Duensing S, Heckmann D, Sültmann H., Free PMC Article | 02/10/2018 |
| the miR-9 family of microRNAs (miRNAS) downregulates the expression of CBX7. In turn, CBX7 represses miR-9-1 and miR-9-2 as part of a regulatory negative feedback loop. | CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a).
O'Loghlen A, Brookes S, Martin N, Rapisarda V, Peters G, Gil J., Free PMC Article | 10/29/2016 |
| these results suggest that the retention of CBX7 expression may play a role in the modulation of chemosensitivity of lung cancer patients to the treatment with irinotecan and etoposide | Restoration of CBX7 expression increases the susceptibility of human lung carcinoma cells to irinotecan treatment.
Cacciola NA, Sepe R, Forzati F, Federico A, Pellecchia S, Malapelle U, De Stefano A, Rocco D, Fusco A, Pallante P. | 08/20/2016 |
| Data show that polycomb-group proteins BMI1, PHC3, CBX6 and CBX7 expression was significantly increased during imatinib treatment. | Polycomb genes are associated with response to imatinib in chronic myeloid leukemia.
Crea F, Di Paolo A, Liu HH, Polillo M, Clermont PL, Guerrini F, Ciabatti E, Ricci F, Baratè C, Fontanelli G, Barsotti S, Morganti R, Danesi R, Wang Y, Petrini M, Galimberti S, Helgason CD., Free PMC Article | 08/13/2016 |