| TARDBP drives T-cell acute lymphoblastic leukemia progression by binding MDM2 mRNA, involving beta-catenin pathway. | TARDBP drives T-cell acute lymphoblastic leukemia progression by binding MDM2 mRNA, involving β-catenin pathway.
Mai Y, Jing Z, Sun P, Wang Y, Dong P, Liu J. | 10/28/2024 |
| DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43. | DNAJA2 and Hero11 mediate similar conformational extension and aggregation suppression of TDP-43.
Lam AYW, Tsuboyama K, Tadakuma H, Tomari Y., | 10/25/2024 |
| Electrostatics Choreographs the Aggregation Dynamics of Full-Length TDP-43 via a Monomeric Amyloid Precursor. | Electrostatics Choreographs the Aggregation Dynamics of Full-Length TDP-43 via a Monomeric Amyloid Precursor.
Doke AA, Jha SK. | 10/22/2024 |
| HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43. | HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43.
Yang J, Li Y, Li H, Zhang H, Guo H, Zheng X, Yu XF, Wei W., Free PMC Article | 10/18/2024 |
| The TDP-43/TP63 Positive Feedback Circuit Promotes Esophageal Squamous Cell Carcinoma Progression. | The TDP-43/TP63 Positive Feedback Circuit Promotes Esophageal Squamous Cell Carcinoma Progression.
Li W, Yang Y, Huang L, Yu X, Wang T, Zhang N, Yang M., Free PMC Article | 10/3/2024 |
| TDP-43 Is Associated with Subiculum and Cornu Ammonis 1 Hippocampal Subfield Atrophy in Primary Age-Related Tauopathy. | TDP-43 Is Associated with Subiculum and Cornu Ammonis 1 Hippocampal Subfield Atrophy in Primary Age-Related Tauopathy.
Youssef H, Gatto RG, Pham NTT, Petersen RC, Machulda MM, Reichard RR, Dickson DW, Jack CR, Whitwell JL, Josephs KA., Free PMC Article | 09/30/2024 |
| TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition. | TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition.
Torres P, Rico-Rios S, Ceron-Codorniu M, Santacreu-Vilaseca M, Seoane-Miraz D, Jad Y, Ayala V, Mariño G, Beltran M, Miralles MP, Andrés-Benito P, Fernandez-Irigoyen J, Santamaria E, López-Otín C, Soler RM, Povedano M, Ferrer I, Pamplona R, Wood MJA, Varela MA, Portero-Otin M., Free PMC Article | 09/23/2024 |
| TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells. | TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells.
Ceron-Codorniu M, Torres P, Fernàndez-Bernal A, Rico-Rios S, Serrano JC, Miralles MP, Beltran M, Garcera A, Soler RM, Pamplona R, Portero-Otín M., Free PMC Article | 08/30/2024 |
| NMR assignments for the C-terminal domain of human TDP-43. | NMR assignments for the C-terminal domain of human TDP-43.
Pantoja-Uceda D, Stuani C, Laurents DV, McDermott AE, Buratti E, Mompeán M. | 07/26/2024 |
| Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies. | Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies.
Robinson JL, Suh E, Xu Y, Hurtig HI, Elman L, McMillan CT, Irwin DJ, Porta S, Van Deerlin VM, Lee EB., Free PMC Article | 06/28/2024 |
| Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database. | Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database.
Woodworth DC, Nguyen KM, Sordo L, Scambray KA, Head E, Kawas CH, Corrada MM, Nelson PT, Sajjadi SA., Free PMC Article | 06/28/2024 |
| Elevated nuclear TDP-43 induces constitutive exon skipping. | Elevated nuclear TDP-43 induces constitutive exon skipping.
Carmen-Orozco RP, Tsao W, Ye Y, Sinha IR, Chang K, Trinh VT, Chung W, Bowden K, Troncoso JC, Blackshaw S, Hayes LR, Sun S, Wong PC, Ling JP., Free PMC Article | 06/20/2024 |
| Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study. | Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study.
Kochen NN, Seaney D, Vasandani V, Murray M, Braun AR, Sachs JN., | 06/14/2024 |
| TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner. | TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner.
Provasek VE, Kodavati M, Kim B, Mitra J, Hegde ML., Free PMC Article | 06/13/2024 |
| RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo. | RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo.
Scherer NM, Maurel C, Graus MS, McAlary L, Richter G, Radford RAW, Hogan A, Don EK, Lee A, Yerbury J, Francois M, Chung RS, Morsch M., Free PMC Article | 06/10/2024 |
| Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1. | Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1.
Pokrishevsky E, DuVal MG, McAlary L, Louadi S, Pozzi S, Roman A, Plotkin SS, Dijkstra A, Julien JP, Allison WT, Cashman NR., Free PMC Article | 06/6/2024 |
| Dissecting the effect of ALS mutation S375G on the conformational properties and aggregation dynamics of TDP-43370-375 fragment. | Dissecting the effect of ALS mutation S375G on the conformational properties and aggregation dynamics of TDP-43(370-375) fragment.
Xu Z, Zhang J, Tang J, Gong Y, Zou Y, Zhang Q. | 06/5/2024 |
| The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis. | The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis.
Zibold J, Lessard LER, Picard F, da Silva LG, Zadorozhna Y, Streichenberger N, Belotti E, Osseni A, Emerit A, Errazuriz-Cerda E, Michel-Calemard L, Menassa R, Coudert L, Wiessner M, Stucka R, Klopstock T, Simonetti F, Hutten S, Nonaka T, Hasegawa M, Strom TM, Bernard E, Ollagnon E, Urtizberea A, Dormann D, Petiot P, Schaeffer L, Senderek J, Leblanc P., Free PMC Article | 05/7/2024 |
| Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS. | Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS.
Lochner RH, Arumanayagam AS, Powell SZ, Masdeu JC, Pascual B, Cykowski MD., Free PMC Article | 04/25/2024 |
| Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia. | Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia.
Nementzik LR, Thumbadoo KM, Murray HC, Gordon D, Yang S, Blair IP, Turner C, Faull RLM, Curtis MA, McLean C, Nicholson GA, Swanson MEV, Scotter EL., Free PMC Article | 04/24/2024 |
| Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases. | Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases.
Lee SH, Pham D, Kosa E, Agbas A., Free PMC Article | 04/17/2024 |
| RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation. | RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation.
Demongin C, Tranier S, Joshi V, Ceschi L, Desforges B, Pastré D, Hamon L., Free PMC Article | 04/16/2024 |
| A novel long non-coding RNA LINC00524 facilitates invasion and metastasis through interaction with TDP43 in breast cancer. | A novel long non-coding RNA LINC00524 facilitates invasion and metastasis through interaction with TDP43 in breast cancer.
Sun X, Li W, Li G, Yang H, Jiang Z, Shen L, Shen Y, Liu Y, Wang G., Free PMC Article | 04/8/2024 |
| RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention. | RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.
Dos Passos PM, Hemamali EH, Mamede LD, Hayes LR, Ayala YM., Free PMC Article | 03/29/2024 |
| TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43. | TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43.
Godoy-Corchuelo JM, Ali Z, Brito Armas JM, Martins-Bach AB, García-Toledo I, Fernández-Beltrán LC, López-Carbonero JI, Bascuñana P, Spring S, Jimenez-Coca I, Muñoz de Bustillo Alfaro RA, Sánchez-Barrena MJ, Nair RR, Nieman BJ, Lerch JP, Miller KL, Ozdinler HP, Fisher EMC, Cunningham TJ, Acevedo-Arozena A, Corrochano S., Free PMC Article | 03/28/2024 |