| [Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways]. | [Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways].
Baksheeva VE, Zamyatnin AA Jr, Zernii EY. | 01/5/2024 |
| Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling. | Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling.
Baksheeva VE, Baldin AV, Zalevsky AO, Nazipova AA, Kazakov AS, Vladimirov VI, Gorokhovets NV, Devred F, Philippov PP, Bazhin AV, Golovin AV, Zamyatnin AA Jr, Zinchenko DV, Tsvetkov PO, Permyakov SE, Zernii EY., Free PMC Article | 12/18/2021 |
| Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells. | Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells.
Grosshans HK, Fischer TT, Steinle JA, Brill AL, Ehrlich BE., Free PMC Article | 07/3/2021 |
| Disorder in a two-domain neuronal Ca(2+)-binding protein regulates domain stability and dynamics using ligand mimicry. | Disorder in a two-domain neuronal Ca(2+)-binding protein regulates domain stability and dynamics using ligand mimicry.
Staby L, Kemplen KR, Stein A, Ploug M, Clarke J, Skriver K, Heidarsson PO, Kragelund BB., Free PMC Article | 04/3/2021 |
| Membrane Binding of Neuronal Calcium Sensor-1: Highly Specific Interaction with Phosphatidylinositol-3-Phosphate. | Membrane Binding of Neuronal Calcium Sensor-1: Highly Specific Interaction with Phosphatidylinositol-3-Phosphate.
Baksheeva VE, Nemashkalova EL, Firsov AM, Zalevsky AO, Vladimirov VI, Tikhomirova NK, Philippov PP, Zamyatnin AA Jr, Zinchenko DV, Antonenko YN, Permyakov SE, Zernii EY., Free PMC Article | 04/3/2021 |
| NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin. | NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin.
Bong AHL, Robitaille M, Milevskiy MJG, Roberts-Thomson SJ, Monteith GR., Free PMC Article | 02/6/2021 |
| NCS-1 levels were reduced in a human iPSC-model of familial Parkinson's. | Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.
Benkert J, Hess S, Roy S, Beccano-Kelly D, Wiederspohn N, Duda J, Simons C, Patil K, Gaifullina A, Mannal N, Dragicevic E, Spaich D, Müller S, Nemeth J, Hollmann H, Deuter N, Mousba Y, Kubisch C, Poetschke C, Striessnig J, Pongs O, Schneider T, Wade-Martins R, Patel S, Parlato R, Frank T, Kloppenburg P, Liss B., Free PMC Article | 03/7/2020 |
| NCS1 regulates endoplasmic reticulum-mitochondria cross-talk, which is impaired in Wolfram syndrome | ER-mitochondria cross-talk is regulated by the Ca(2+) sensor NCS1 and is impaired in Wolfram syndrome.
Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C. | 12/21/2019 |
| High NCS1 expression is associated with Hepatocellular Carcinoma. | Hepatocellular Carcinoma Outcome Is Predicted by Expression of Neuronal Calcium Sensor 1.
Schuette D, Moore LM, Robert ME, Taddei TH, Ehrlich BE., Free PMC Article | 09/14/2019 |
| NCS-1, a calcium-binding protein, is associated with clinicopathologic features of aggressiveness in breast cancer cells and worse outcome in two breast cancer patient cohorts | Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival.
Moore LM, England A, Ehrlich BE, Rimm DL., Free PMC Article | 04/7/2018 |
| Results show that although NCS-1 Var2mRNA can be detected, protein expression was not detectable. When overexpressed in cell lines NCS-1 Var2 appears to be folded properly, yet it has a lower calcium affinity. Because most NCS-1 binding to its protein partners requires calcium binding, it is unlikely that NCS-1 Var2 would play a major regulatory role in cells. | Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics.
Wang B, Boeckel GR, Huynh L, Nguyen L, Cao W, De La Cruz EM, Kaftan EJ, Ehrlich BE., Free PMC Article | 08/26/2017 |
| structural and dynamical response of NCS-1 protein to elevated temperature may be one of its intrinsic functional properties | Temperature-Dependent Conformational Properties of Human Neuronal Calcium Sensor-1 Protein Revealed by All-Atom Simulations.
Zhu Y, Ma B, Qi R, Nussinov R, Zhang Q., Free PMC Article | 01/14/2017 |
| Lithium normalizes gamma band oscillations mediated by P/Q-type calcium channels modulated by NCS-1. | Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons.
D'Onofrio S, Urbano FJ, Messias E, Garcia-Rill E., Free PMC Article | 10/1/2016 |
| Study determined the salient features of the folding free-energy landscapes of the Mg2+-bound and apo states of NCS-1 | Single-molecule folding mechanisms of the apo- and Mg(2+)-bound states of human neuronal calcium sensor-1.
Naqvi MM, Heidarsson PO, Otazo MR, Mossa A, Kragelund BB, Cecconi C., Free PMC Article | 04/2/2016 |
| results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors | R102Q mutation shifts the salt-bridge network and reduces the structural flexibility of human neuronal calcium sensor-1 protein.
Zhu Y, Wu Y, Luo Y, Zou Y, Ma B, Zhang Q. | 08/29/2015 |
| single-molecule optical tweezers were used to monitor misfolding reactions of the human neuronal calcium sensor-1. | Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1.
Heidarsson PO, Naqvi MM, Otazo MR, Mossa A, Kragelund BB, Cecconi C., Free PMC Article | 04/25/2015 |
| A strong liason was characterized between myristoylation and cryptic EF-1 in NCS-1. | Liaison between myristoylation and cryptic EF-hand motif confers Ca(2+) sensitivity to neuronal calcium sensor-1.
Rajanikanth V, Sharma AK, Rajyalakshmi M, Chandra K, Chary KV, Sharma Y. | 04/18/2015 |
| The functional link in substantia nigra dopamine neurons between Cav1.3- L-type-Ca2+ channels and D2-autoreceptor activity is an adaptive signalling network controlled by NCS-1. | Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.
Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Lujan R, Malenka RC, Striessnig J, Liss B., Free PMC Article | 09/27/2014 |
| NCS1 has evolved a remarkable complex interdomain cooperativity and a fundamentally different folding mechanism compared to structurally related proteins. | Single-molecule folding mechanism of an EF-hand neuronal calcium sensor.
Heidarsson PO, Otazo MR, Bellucci L, Mossa A, Imparato A, Paci E, Corni S, Di Felice R, Kragelund BB, Cecconi C. | 05/17/2014 |
| data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of Cocaine Abuse in individuals of African descent. | Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans.
Multani PK, Clarke TK, Narasimhan S, Ambrose-Lanci L, Kampman KM, Pettinati HM, Oslin DW, O'Brien CP, Berrettini WH, Lohoff FW., Free PMC Article | 05/4/2013 |
| [review] Receptor interaction properties in schizophrenia are dependent upon NCS-1, a protein found to regulate the phosphorylation, trafficking, and signaling profile of the D2 dopamine receptor (D2R) in neurons. | Dopamine receptor interacting proteins: targeting neuronal calcium sensor-1/D2 dopamine receptor interaction for antipsychotic drug development.
Kabbani N, Woll MP, Nordman JC, Levenson R., Free PMC Article | 10/6/2012 |
| the C-terminal tail is important for regulating the conformational stability of NCS1 in Ca(2+)-activated state | The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺₋ activated state.
Heidarsson PO, Bjerrum-Bohr IJ, Jensen GA, Pongs O, Finn BE, Poulsen FM, Kragelund BB. | 07/14/2012 |
| analysis of the interaction between the D2 dopamine receptor and neuronal calcium sensor-1 | Interaction between the D2 dopamine receptor and neuronal calcium sensor-1 analyzed by fluorescence anisotropy.
Woll MP, De Cotiis DA, Bewley MC, Tacelosky DM, Levenson R, Flanagan JM., Free PMC Article | 12/24/2011 |
| it is possible to protect cells from paclitaxel-induced degradation of NCS-1 by inhibiting calpain activity | Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.
Benbow JH, DeGray B, Ehrlich BE., Free PMC Article | 12/10/2011 |
| NCS-1 is a novel regulator of cardiac calcium signaling, specifically in immature and hypertrophic hearts. | Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.
Nakamura TY, Jeromin A, Mikoshiba K, Wakabayashi S. | 10/22/2011 |