| Study uncovers a novel tumor-suppressor role for CLP/Cotl1 and identify the downstream effectors interleukin 24 (IL-24)/PERP and IL-24/MAPK/ERK/TGF-beta. | Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling.
Xia L, Xiao X, Liu WL, Song Y, Liu TJJ, Li YJ, Zacksenhaus E, Hao XJ, Ben-David Y. | 10/20/2018 |
| our combined results elucidated genetic and epigenetic silencing of miR-506-3p enhances COTL1 oncogene expression to foster NSCLC progression. | Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression.
Guo S, Yang P, Jiang X, Li X, Wang Y, Zhang X, Sun B, Zhang Y, Jia Y., Free PMC Article | 03/10/2018 |
| The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied. | Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis.
Basavarajappa D, Wan M, Lukic A, Steinhilber D, Samuelsson B, Rådmark O., Free PMC Article | 10/4/2014 |
| COTL1 regulates lamellipodia dynamics in part by protecting F-actin from cofilin-mediated disassembly. | Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.
Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD., Free PMC Article | 09/20/2014 |
| PAI-RBP1 and C1orf142 expression levels are higher in 95D (high metastatic potential) than in 95C (low metastatic potential) non-small lung cancer cells, whereas COTL1 expression level is lower in 95D when compared to 95C cells. | Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential.
Sun W, Guo C, Meng X, Yu Y, Jin Y, Tong D, Geng J, Huang Q, Qi J, Liu A, Guan R, Xu L, Sun D, Ji W, Liu P, Liu F, Sun H, Ji G, Fu S, Bai J. | 05/24/2014 |
| Up-regulated COTL-1 expression in small cell lung cancer was validated by Western blot analysis, immunohistochemistry, and qRT-qPCR. | Proteomic analysis of human small cell lung cancer tissues: up-regulation of coactosin-like protein-1.
Jeong HC, Kim GI, Cho SH, Lee KH, Ko JJ, Yang JH, Chung KH. | 05/21/2011 |
| Results of the present study support a role for CLP as a chaperoning scaffold factor, influencing both the stability and the activity of 5-LO. | Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.
Esser J, Rakonjac M, Hofmann B, Fischer L, Provost P, Schneider G, Steinhilber D, Samuelsson B, Rådmark O. | 01/25/2010 |
| We found that coactosin-like1 (COTL1) were highly expressed in rheumatoid arthritis patients compared with healthy controls | Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.
Jin EH, Shim SC, Kim HG, Chae SC, Chung HT, Jin EH, Shim SC, Kim HG, Chae SC, Chung HT., Free PMC Articles: PMC2701985, PMC2701985 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.
Jin EH, Shim SC, Kim HG, Chae SC, Chung HT, Jin EH, Shim SC, Kim HG, Chae SC, Chung HT., Free PMC Articles: PMC2701985, PMC2701985 | 04/8/2009 |
| Coactosin-like protein (CLP) up-regulates Ca(2+)-induced 5-lipoxygenase (5LO) activity, and increases the amount of Leukotriene A(4) formed by 5LO. | Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.
Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O., Free PMC Article | 01/21/2010 |
| coactosin-like protein (CLP) is an actin-binding protein as well as a 5-lipoxygenase binding partner | Expression, purification and preliminary crystallographic studies of human coactosin-like protein.
Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W. | 01/21/2010 |
| structural analysis shows that CLP forms a polymer along the crystallographic b axis with the exact same repeat distance as F-actin; a model for the CLP polymer and F-actin binding has therefore been proposed. | Crystal structure of human coactosin-like protein at 1.9 A resolution.
Li X, Liu X, Lou Z, Duan X, Wu H, Liu Y, Rao Z., Free PMC Article | 01/21/2010 |
| preliminary crystallographic studies of human coactosin-like protein (CLP) | Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP).
Li X, Liu X, Zhao Q, Liu Y, Duan X, Rao Z. | 01/21/2010 |
| extended region of beta4-beta5 of hCLP (residue 66-75) was found very flexible and very important for F-actin binding. The C-terminal residues of human coactosin-like protein were not involved in F-actin binding | Binding model of human coactosin-like protein with filament actin revealed by mutagenesis.
Dai H, Huang W, Xu J, Yao B, Xiong S, Ding H, Tang Y, Liu H, Wu J, Shi Y. | 01/21/2010 |
| NMR resonance assignments and the secondary structures of human Coactosin like protein (hCLP) D123N | 1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N.
Dai H, Wu J, Xu Y, Yajun T, Husheng D, Shi Y. | 01/21/2010 |
| CLP 57-65 peptide elicits immediate-type hypersensitivity. Identical peptides are recognized by cellular and humoral immune systems to a tumor-associated antigen. CLP 15-24 and 104-113 might be used for peptide-based immunotherapy of HLA-A2(+) cancers. | Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method.
Nakatsura T, Senju S, Ito M, Nishimura Y, Itoh K. | 01/21/2010 |