| LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder. | LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder.
Chettle J, Louie RJ, Larner O, Best R, Chen K, Morris J, Dedeic Z, Childers A, Rogers RC, DuPont BR, Skinner C, Küry S, Uguen K, Planes M, Monteil D, Li M, Eliyahu A, Greenbaum L, Mor N, Besnard T, Isidor B, Cogné B, Blesson A, Comi A, Wentzensen IM, Vuocolo B, Lalani SR, Sierra R, Berry L, Carter K, Sanders SJ, Blagden SP., Free PMC Article | 10/17/2024 |
| LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway. | LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
Ma J, Dong D, Qi H, Li J, Yu H, Hu X, Sun L, Shen L. | 09/19/2024 |
| Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1. | Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1.
Kozlov G, Jiang J, Rutherford T, Noronha AM, Wilds CJ, Gehring K., Free PMC Article | 08/5/2024 |
| Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry. | Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry.
Bley H, Krisp C, Schöbel A, Hehner J, Schneider L, Becker M, Stegmann C, Heidenfels E, Nguyen-Dinh V, Schlüter H, Gerold G, Herker E., Free PMC Article | 06/6/2024 |
| [1]H, [13]C, and [15]N resonance assignments of the La Motif of the human La-related protein 1. | (1)H, (13)C, and (15)N resonance assignments of the La Motif of the human La-related protein 1.
Smith BC, Silvers R. | 06/1/2024 |
| O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/beta-catenin signalling. | O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β-catenin signalling.
Cui Z, He J, Zhu J, Ni W, Liu L, Bian Z, Mao S, Gu S, Shan Y, Chu Z, Wu Q, Lu J, Liu Y, Sun F, Pan Q, Zhang Y, Huang N, Ma J., Free PMC Article | 04/26/2023 |
| Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326. | Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326.
Zhang W, Cao C, Shen J, Shan S, Tong Y, Cai H, Han Z, Chai H., Free PMC Article | 02/4/2023 |
| Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis. | Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.
Desi N, Tong QY, Teh V, Chan JJ, Zhang B, Tabatabaeian H, Tan HQ, Kapeli K, Jin W, Lim CY, Kwok ZH, Tan HT, Wang S, Siew BE, Lee KC, Chong CS, Tan KK, Yang H, Kappei D, Yeo GW, Chung MCM, Tay Y., Free PMC Article | 03/5/2022 |
| LARP1 isoform expression in human cancer cell lines. | LARP1 isoform expression in human cancer cell lines.
Schwenzer H, Abdel Mouti M, Neubert P, Morris J, Stockton J, Bonham S, Fellermeyer M, Chettle J, Fischer R, Beggs AD, Blagden SP., Free PMC Article | 12/4/2021 |
| The LARP1 La-Module recognizes both ends of TOP mRNAs. | The LARP1 La-Module recognizes both ends of TOP mRNAs.
Al-Ashtal HA, Rubottom CM, Leeper TC, Berman AJ., Free PMC Article | 12/4/2021 |
| The RNA-binding protein LARP1 is dispensable for pancreatic beta-cell function and mass. | The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass.
Werneck-de-Castro JP, Peçanha FLM, Silvestre DH, Bernal-Mizrachi E., Free PMC Article | 10/16/2021 |
| Hsa_circRNA_002144 promotes growth and metastasis of colorectal cancer through regulating miR-615-5p/LARP1/mTOR pathway. | Hsa_circRNA_002144 promotes growth and metastasis of colorectal cancer through regulating miR-615-5p/LARP1/mTOR pathway.
Wu M, Kong C, Cai M, Huang W, Chen Y, Wang B, Liu X., Free PMC Article | 10/2/2021 |
| The SARS-CoV-2 RNA interactome. | The SARS-CoV-2 RNA interactome.
Lee S, Lee YS, Choi Y, Son A, Park Y, Lee KM, Kim J, Kim JS, Kim VN., Free PMC Article | 07/17/2021 |
| mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. | mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Jia JJ, Lahr RM, Solgaard MT, Moraes BJ, Pointet R, Yang AD, Celucci G, Graber TE, Hoang HD, Niklaus MR, Pena IA, Hollensen AK, Smith EM, Chaker-Margot M, Anton L, Dajadian C, Livingstone M, Hearnden J, Wang XD, Yu Y, Maier T, Damgaard CK, Berman AJ, Alain T, Fonseca BD., Free PMC Article | 05/15/2021 |
| Knockdown of KCNQ1OT1 Inhibits Proliferation, Invasion, and Drug Resistance by Regulating miR-129-5p-Mediated LARP1 in Osteosarcoma. | Knockdown of KCNQ1OT1 Inhibits Proliferation, Invasion, and Drug Resistance by Regulating miR-129-5p-Mediated LARP1 in Osteosarcoma.
Zhang Y, Cai W, Zou Y, Zhang H., Free PMC Article | 05/1/2021 |
| The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction. | The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.
Smith EM, Benbahouche NEH, Morris K, Wilczynska A, Gillen S, Schmidt T, Meijer HA, Jukes-Jones R, Cain K, Jones C, Stoneley M, Waldron JA, Bell C, Fonseca BD, Blagden S, Willis AE, Bushell M., Free PMC Article | 01/23/2021 |
| These results establish the central role of LARP1 in TOP mRNA regulation on a transcriptome scale and show how it connects mTORC1 to a tunable and dynamic program of gene expression that is tailored to specific biological contexts. | Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5' TOP motifs.
Philippe L, van den Elzen AMG, Watson MJ, Thoreen CC., Free PMC Article | 07/18/2020 |
| The molecular mechanism underlying TOP Rps6 mRNA binding to LARP1 has been deciphered. | Capturing the Mechanism Underlying TOP mRNA Binding to LARP1.
Cassidy KC, Lahr RM, Kaminsky JC, Mack S, Fonseca BD, Das SR, Berman AJ, Durrant JD., Free PMC Article | 07/4/2020 |
| L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients. | L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients.
Bello E, Kerry J, Singh S, Yip BH, Kušec R, Killick S, Raynaud S, Boultwood J, Pellagatti A., Free PMC Article | 10/12/2019 |
| The results support a model whereby the translation of TOP mRNAs is controlled by a growth-regulated competition between eIF4F and LARP1 for their 5' ends. | La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region.
Philippe L, Vasseur JJ, Debart F, Thoreen CC., Free PMC Article | 07/6/2019 |
| circ-BANP promoted LARP1 expression through sponging miR-503 in lung cancer cells. | CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression.
Han J, Zhao G, Ma X, Dong Q, Zhang H, Wang Y, Cui J. | 01/19/2019 |
| we suggest that the dysfunction of the XIST/miR-374a/LARP1 axis contributes to non-small cell lung cancer (NSCLC)and may serve as a promising therapeutic strategy for treatment. | LARP1 is regulated by the XIST/miR-374a axis and functions as an oncogene in non-small cell lung carcinoma.
Xu Z, Xu J, Lu H, Lin B, Cai S, Guo J, Zang F, Chen R. | 07/21/2018 |
| Thus, in response to cellular mTOR activity, LARP1 serves as a phosphorylation-sensitive molecular switch for turning off or on ribosomal protein mRNA translation and subsequent ribosome biogenesis. | LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.
Hong S, Freeberg MA, Han T, Kamath A, Yao Y, Fukuda T, Suzuki T, Kim JK, Inoki K., Free PMC Article | 03/17/2018 |
| A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA. | The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.
Maraia RJ, Mattijssen S, Cruz-Gallardo I, Conte MR., Free PMC Article | 02/17/2018 |
| The authors show that LARP1 directly binds the cap and adjacent 5'TOP motif of TOP mRNAs, effectively impeding access of eIF4E to the cap and preventing eIF4F assembly. Thus, LARP1 is a specialized TOP mRNA cap-binding protein that controls ribosome biogenesis. | La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.
Lahr RM, Fonseca BD, Ciotti GE, Al-Ashtal HA, Jia JJ, Niklaus MR, Blagden SP, Alain T, Berman AJ., Free PMC Article | 02/10/2018 |