| Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment. | Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment.
Koganesawa M, Dwyer DF, Alhallak K, Nagai J, Zaleski K, Samuchiwal S, Hiroaki H, Nishida A, Hirsch TI, Brennan PJ, Puder M, Balestrieri B., | 04/5/2024 |
| [Possible involvement of FFAR1 signaling in mouse emotional behaviors through the regulation of brain monoamine releases]. | [Possible involvement of FFAR1 signaling in mouse emotional behaviors through the regulation of brain monoamine releases].
Kurihara T. | 11/7/2023 |
| GPR40 deficiency worsens metabolic syndrome-associated periodontitis in mice. | GPR40 deficiency worsens metabolic syndrome-associated periodontitis in mice.
Li Y, Lu Z, Kirkwood CL, Kirkwood KL, Wank SA, Li AJ, Lopes-Virella MF, Huang Y., Free PMC Article | 08/25/2023 |
| Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice. | Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice.
Lin X, Wang L, Lu X, Zhang Y, Zheng R, Chen R, Zhang W., Free PMC Article | 02/23/2023 |
| Loss of GPR40 in LDL receptor-deficient mice exacerbates high-fat diet-induced hyperlipidemia and nonalcoholic steatohepatitis. | Loss of GPR40 in LDL receptor-deficient mice exacerbates high-fat diet-induced hyperlipidemia and nonalcoholic steatohepatitis.
Lu Z, Li Y, Li AJ, Syn WK, Wank SA, Lopes-Virella MF, Huang Y., Free PMC Article | 11/12/2022 |
| GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression. | GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.
Königs V, Pierre S, Schicht M, Welss J, Hahnefeld L, Rimola V, Lütjen-Drecoll E, Geisslinger G, Scholich K. | 05/7/2022 |
| Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice. | Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice.
Croze ML, Guillaume A, Ethier M, Fergusson G, Tremblay C, Campbell SA, Maachi H, Ghislain J, Poitout V. | 09/11/2021 |
| Effect of omega-3 fatty acids on glucose homeostasis: role of free fatty acid receptor 1. | Effect of omega-3 fatty acids on glucose homeostasis: role of free fatty acid receptor 1.
El-Fayoumi SH, Mahmoud AAA, Fahmy A, Ibrahim IAAE. | 08/14/2021 |
| A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40. | A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40.
Spyrantis A, Krieger J, Stifter K, Boehm BO, Schirmbeck R., Free PMC Article | 07/31/2021 |
| GPR40 receptor agonist TAK-875 improves cognitive deficits and reduces beta-amyloid production in APPswe/PS1dE9 mice. | GPR40 receptor agonist TAK-875 improves cognitive deficits and reduces β-amyloid production in APPswe/PS1dE9 mice.
Liu C, Cheng ZY, Xia QP, Hu YH, Wang C, He L. | 07/31/2021 |
| GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice. | GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice.
Lu Z, Li Y, Syn WK, Li AJ, Ritter WS, Wank SA, Lopes-Virella MF, Huang Y., Free PMC Article | 02/13/2021 |
| Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. | Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms.
Engel DF, Bobbo VCD, Solon CS, Nogueira GA, Moura-Assis A, Mendes NF, Zanesco AM, Papangelis A, Ulven T, Velloso LA., Free PMC Article | 12/26/2020 |
| GPR40 activation initiates store-operated Ca(2+) entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic beta-cells. | GPR40 activation initiates store-operated Ca(2+) entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells.
Usui R, Yabe D, Fauzi M, Goto H, Botagarova A, Tokumoto S, Tatsuoka H, Tahara Y, Kobayashi S, Manabe T, Baba Y, Kurosaki T, Herrera PL, Ogura M, Nagashima K, Inagaki N., Free PMC Article | 11/21/2020 |
| Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1. | Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1.
Nishino K, Uesugi H, Hirasawa A, Ohtera A, Miyamae Y, Neffati M, Isoda H, Kambe T, Masuda S, Irie K, Nagao M. | 08/22/2020 |
| GPR40 full agonist can induce periphery-derived weight reduction. | GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve.
Ueno H, Ito R, Abe SI, Ogino H, Maruyama M, Miyashita H, Miyamoto Y, Moritoh Y, Tsujihata Y, Takeuchi K, Nishigaki N., Free PMC Article | 03/7/2020 |
| High GRP40 expression is associated with epileptic seizure. | GPR40 modulates epileptic seizure and NMDA receptor function.
Yang Y, Tian X, Xu D, Zheng F, Lu X, Zhang Y, Ma Y, Li Y, Xu X, Zhu B, Wang X., Free PMC Article | 10/5/2019 |
| Palmitic acid hydroxystearic acids activate GPR40, which is involved in their beneficial metabolic effects. | Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB., Free PMC Article | 06/8/2019 |
| Ffar1 expression is markedly down-regulated under diabetic conditions. | Suppression of free fatty acid receptor 1 expression in pancreatic β-cells in obese type 2 diabetic db/db mice: a potential role of pancreatic and duodenal homeobox factor 1.
Kohara K, Obata A, Kimura T, Shimoda M, Moriuchi S, Okauchi S, Hirukawa H, Mune T, Kaku K, Kaneto H. | 05/18/2019 |
| Results indicate that FFAR4 plays a more critical role than FFAR1 in mediation of fat-regulated neurotensin release from neuroendocrine cells and in inhibitory crosstalk between MEK/ERK1/2 and AMPK in the control of NT release downstream of FFAR1 and FFAR4. | FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice.
Li J, Song J, Li X, Rock SB, Sinner HF, Weiss HL, Weiss T, Townsend CM Jr, Gao T, Evers BM., Free PMC Article | 03/2/2019 |
| FFAR1 point mutation R258W abrogates fatty acid-induced insulin secretion | Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance.
Sabrautzki S, Kaiser G, Przemeck GKH, Gerst F, Lorza-Gil E, Panse M, Sartorius T, Hoene M, Marschall S, Häring HU, Hrabě de Angelis M, Ullrich S., Free PMC Article | 12/22/2018 |
| We found that FFAR1-/- female mice showed significant impairments in maternal behavior, and exhibited an emotionally altered behavior, when compared to WT mice. Our findings suggest that the dysfunction of brain PUFA-GPR40/FFAR1 signaling might induce damage to emotional and maternal behavior in female mice. | The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice.
Aizawa F, Ogaki Y, Kyoya N, Nishinaka T, Nakamoto K, Kurihara T, Hirasawa A, Miyata A, Tokuyama S. | 05/5/2018 |
| GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy | GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.
Satapati S, Qian Y, Wu MS, Petrov A, Dai G, Wang SP, Zhu Y, Shen X, Muise ES, Chen Y, Zycband E, Weinglass A, Di Salvo J, Debenham JS, Cox JM, Lan P, Shah V, Previs SF, Erion M, Kelley DE, Wang L, Howard AD, Shang J., Free PMC Article | 03/31/2018 |
| GPR40 and (GPR120) act in concert in the hypothalamus to reduce energy efficiency and regulate the inflammation associated with obesity. | Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation.
Dragano NRV, Solon C, Ramalho AF, de Moura RF, Razolli DS, Christiansen E, Azevedo C, Ulven T, Velloso LA., Free PMC Article | 03/3/2018 |
| GPR40 role in the bone loss | GPR40 mediates potential positive effects of a saturated fatty acid enriched diet on bone.
Philippe C, Wauquier F, Landrier JF, Bonnet L, Miot-Noirault E, Rochefort GY, Sadoine J, Asrih M, Jornayvaz FR, Bernalier A, Coxam V, Wittrant Y. | 12/30/2017 |
| These findings suggested that dysfunction of the GPR40/FFAR1 signaling pathway altered the endogenous pain control system and that this dysfunction might be associated with the development of chronic pain. | Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice.
Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S., Free PMC Article | 09/30/2017 |