| Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma. | Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma.
Leopizzi M, Mundo L, Messina E, Campolo F, Lazzi S, Angeloni A, Marchese C, Leoncini L, Giordano C, Slack F, Trivedi P, Anastasiadou E., Free PMC Article | 02/5/2024 |
| ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells. | ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells.
Zhang L, Gao Y. | 02/1/2024 |
| Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis. | Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
Provera A, Ramavath NN, Gadipudi LL, Gigliotti CL, Boggio E, Vecchio C, Stoppa I, Rolla R, Boldorini R, Pirisi M, Smirne C, Albano E, Dianzani U, Sutti S., Free PMC Article | 12/20/2023 |
| Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients. | Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients.
Zhan XK, Liu XK, Zhang S, Chen H., Free PMC Article | 12/4/2023 |
| Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction. | Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction.
Fan X, Xu ZB, Li CL, Zhang HY, Peng YQ, He BX, Liu XQ, Chen DH, Chen D, Akdis CA, Fu QL., Free PMC Article | 03/19/2022 |
| Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-alpha-B7-H2-dependent pathway in human gastric cancer. | Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-α-B7-H2-dependent pathway in human gastric cancer.
Shan ZG, Chen J, Liu JS, Zhang JY, Wang TT, Teng YS, Mao FY, Cheng P, Zou QM, Zhou WY, Peng LS, Zhao YL, Zhuang Y., Free PMC Article | 02/12/2022 |
| Dysregulated NF-kappaB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. | Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
Maurer DM, Adamik J, Santos PM, Shi J, Shurin MR, Kirkwood JM, Storkus WJ, Butterfield LH., Free PMC Article | 10/9/2021 |
| [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease]. | [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease].
Chen X, Wang F, Cong X, Shen Q, Chen L. | 01/2/2021 |
| Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.
Rujas E, Cui H, Sicard T, Semesi A, Julien JP., Free PMC Article | 10/24/2020 |
| The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity. | The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity.
Zhang G, Xu Y, Zhang S, Zhou H., Free PMC Article | 09/26/2020 |
| High glucose and advanced glycation end products cause T cell inflammatory response and vascular endothelial dysfunction by upregulating ICOS/ICOSL activity. | ICOS/ICOSL upregulation mediates inflammatory response and endothelial dysfunction in type 2 diabetes mellitus.
Zhang HY, Ruan LB, Li Y, Yang TR, Liu WJ, Jiang YX, Li TR, Quan J, Xuan W. | 01/18/2020 |
| The expression of ICOSL of patient acute myeloid leukemia (AML) cells and ICOS+ Tregs were found to be predictors for survival in patients with AML, with ICOS+ Treg cell subset being a stronger predictor than total Tregs. Results suggested that AML cells expressed ICOSL promote the expansion of ICOS+ Tregs in tumor environment, and ICOS+ Tregs further promote the proliferation of AML cells through secreting IL-10. | Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells.
Han Y, Dong Y, Yang Q, Xu W, Jiang S, Yu Z, Yu K, Zhang S., Free PMC Article | 10/26/2019 |
| study identifies human ICOSLG deficiency as a novel cause of a combined immunodeficiency. | Loss of human ICOSL results in combined immunodeficiency.
Roussel L, Landekic M, Golizeh M, Gavino C, Zhong MC, Chen J, Faubert D, Blanchet-Cohen A, Dansereau L, Parent MA, Marin S, Luo J, Le C, Ford BR, Langelier M, King IL, Divangahi M, Foulkes WD, Veillette A, Vinh DC., Free PMC Article | 09/7/2019 |
| ICOSL-ICOS signaling promoted Treg differentiation from CD4(+) T cells through activation of the phosphoinositide 3-kinase-Akt pathway. MSCs primed with Interleukin-1beta significantly induced Tregs through ICOSL upregulation. We demonstrated that the Treg-inducing activity of MSCs is proportionate to their basal ICOSL expression. | ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells.
Lee HJ, Kim SN, Jeon MS, Yi T, Song SU., Free PMC Article | 11/10/2018 |
| this study found that B7-H2 expression on CD8(+) T cells in colorectal cancer patients' tumor tissues was significantly higher than in non-tumor tissues | Expression of B7-H2 on CD8(+) T cells in colorectal cancer microenvironment and its clinical significance.
Cao Y, Cao T, Zhao W, He F, Lu Y, Zhang G, Hu H, Wang Z. | 09/8/2018 |
| study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels | ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK, El Shikh MEM, Conrad DH., Free PMC Article | 10/28/2017 |
| results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h during their differentiation, and that B7h triggering reversibly inhibits OC differentiation and function both in vitro and in vivo | ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo.
Gigliotti CL, Boggio E, Clemente N, Shivakumar Y, Toth E, Sblattero D, D'Amelio P, Isaia GC, Dianzani C, Yagi J, Rojo JM, Chiocchetti A, Boldorini R, Bosetti M, Dianzani U. | 08/12/2017 |
| The ICOS and ICOSL SNPs examined do not have an apparent effect on the disease susceptibility and prognosis of autoimmune thyroid diseases. | Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases.
Yoshie N, Watanabe M, Inoue N, Kawaguchi H, Hidaka Y, Iwatani Y. | 11/12/2016 |
| Loss-of-function mutations in NIK cause impaired ICOSL expression. | Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.
Willmann KL, Klaver S, Doğu F, Santos-Valente E, Garncarz W, Bilic I, Mace E, Salzer E, Conde CD, Sic H, Májek P, Banerjee PP, Vladimer GI, Haskoloğlu S, Bolkent MG, Küpesiz A, Condino-Neto A, Colinge J, Superti-Furga G, Pickl WF, van Zelm MC, Eibel H, Orange JS, Ikincioğulları A, Boztuğ K., Free PMC Article | 11/21/2015 |
| ICOS-ICOS-L interaction promoted cytokine production and survival in type 2 innate lymphoid cells through STAT5 signaling in asthma. | ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.
Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O., Free PMC Article | 05/16/2015 |
| Our data show that mDCs from patients with AR display impaired expression of ICOSL, and this defect licenses mDCs to promote aberrant IL-13- and IL-5-producing Th2 cell responses. | Impaired ICOSL in human myeloid dendritic cells promotes Th2 responses in patients with allergic rhinitis and asthma.
Shen C, Hupin C, Froidure A, Detry B, Pilette C. | 01/10/2015 |
| These data suggest that rs2294020 SNP of FOXP3 gene and rs378299 SNP of ICOSLG gene are associated with alopecia areata and with a reduced expression of the FOXP3 and ICOSLG genes in alopecia patients. | Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata.
Conteduca G, Rossi A, Megiorni F, Parodi A, Ferrera F, Tardito S, Battaglia F, Kalli F, Negrini S, Pizzuti A, Rizza E, Indiveri F, Fenoglio D, Filaci G. | 09/20/2014 |
| a critical role is described for the rs7282490 ICOSLG region polymorphism associated with immune-mediated diseases in amplifying pattern-recognition receptor initiated inflammatory signaling and cytokine secretion | Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.
Hedl M, Lahiri A, Ning K, Cho JH, Abraham C., Free PMC Article | 07/12/2014 |
| the B7h-ICOS interaction may modulate the spread of cancer metastases | B7h triggering inhibits the migration of tumor cell lines.
Dianzani C, Minelli R, Gigliotti CL, Occhipinti S, Giovarelli M, Conti L, Boggio E, Shivakumar Y, Baldanzi G, Malacarne V, Orilieri E, Cappellano G, Fantozzi R, Sblattero D, Yagi J, Rojo JM, Chiocchetti A, Dianzani U. | 06/28/2014 |
| Findings suggest that the single nucleotide polymorphism (snp) rs4819388 in B7-H2 3'-UTR, through disrupting the regulatory role of miR-24 on B7-H2 expression, contributes to the occurrence of gastric cancer. | A functional variant at miR-24 binding site in B7-H2 alters susceptibility to gastric cancer in a Chinese Han population.
Yang P, Tang R, Zhu J, Zou L, Wu R, Zhou H, Mao Y, Li R, Hua D, Wang W, Zhang H. | 08/31/2013 |