| Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate. | Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate.
Cheropkina H, Catucci G, Marucco A, Fenoglio I, Gilardi G, Sadeghi SJ. | 01/8/2022 |
| Decreases in N'-oxidation activity (V (max)/K (m)) were observed for the FMO1(I303V), FMO3(N61S), FMO3(D132H), FMO3(V257M), and FMO3(E308G) variants in vitro when compared with their respective wild-type isoforms. | Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes.
Perez-Paramo YX, Chen G, Ashmore JH, Watson CJW, Nasrin S, Adams-Haduch J, Wang R, Gao YT, Koh WP, Yuan JM, Lazarus P., Free PMC Article | 04/18/2020 |
| Differential gene expression by SFRP2(+), FMO1(+), and COL11A1(+) fibroblasts suggests roles in matrix deposition, inflammatory cell retention, and connective tissue cell differentiation, respectively. | SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin.
Tabib T, Morse C, Wang T, Chen W, Lafyatis R., Free PMC Article | 05/4/2019 |
| Report developmental regulation of hepatic FMO1 expression. | Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny.
Chen Y, Zane NR, Thakker DR, Wang MZ., Free PMC Article | 01/27/2018 |
| Study tested the genetic effects of three FMOs genes (FMO1, FMO3, and FMO6P) on nicotine dependence by performing targeted sequencing on 2,852 nicotine-dependent and nondependent smokers; identified significant association signals for gene FMO1 and FMO6P | Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.
Zhang TX, Saccone NL, Bierut LJ, Rice JP., Free PMC Article | 04/29/2017 |
| data support the role of FMO3 in the N-oxidation of OLA and implicate for the first time the contribution of FMO1 and its functional *6 variant in OLA disposition | Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients.
Söderberg MM, Haslemo T, Molden E, Dahl ML. | 07/19/2014 |
| polymorphisms in FMO1 are significant risk factors in the development of nicotine dependence and that the mechanism may involve variation in nicotine pharmacology. | Common polymorphisms in FMO1 are associated with nicotine dependence.
Hinrichs AL, Murphy SE, Wang JC, Saccone S, Saccone N, Steinbach JH, Goate A, Stevens VL, Bierut LJ., Free PMC Article | 10/22/2011 |
| The results of this study suggested that the alteration of FMO gene expression is a consequence of the pathological environment linked to oxidative stress related to mutated SOD1. | Flavin-containing monooxygenase mRNA levels are up-regulated in als brain areas in SOD1-mutant mice.
Gagliardi S, Ogliari P, Davin A, Corato M, Cova E, Abel K, Cashman JR, Ceroni M, Cereda C. | 10/1/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.
Searles Nielsen S, McKean-Cowdin R, Farin FM, Holly EA, Preston-Martin S, Mueller BA., Free PMC Article | 01/20/2010 |
| The resulting data showed that N,N-dimethylamphetamine N-oxidation is mainly mediated by FMO1. | Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation.
Lee SK, Kang MJ, Jin C, In MK, Kim DH, Yoo HH. | 01/21/2010 |
| Early studies described in this review document that FMO1 is the most abundant FMO enzyme in the human fetal liver, whereas FMO3 is essentially absent. | Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3.
Hines RN. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesA large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.
Howard TD, Hsu FC, Grzywacz JG, Chen H, Quandt SA, Vallejos QM, Whalley LE, Cui W, Padilla S, Arcury TA. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Ross CJ, Katzov-Eckert H, Dubé MP, Brooks B, Rassekh SR, Barhdadi A, Feroz-Zada Y, Visscher H, Brown AM, Rieder MJ, Rogers PC, Phillips MS, Carleton BC, Hayden MR, CPNDS Consortium. Determination of genetic predisposition to patent ductus arteriosus in preterm infants.
Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC. Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis.
Cereda C, Gabanti E, Corato M, de Silvestri A, Alimonti D, Cova E, Malaspina A, Ceroni M, Cereda C, Gabanti E, Corato M, de Silvestri A, Alimonti D, Cova E, Malaspina A, Ceroni M. | 03/13/2008 |
| data from transient expression assays in HepG2 cells suggested this SNP could account for a 2- to 3-fold loss of FMO1 promoter activity. | Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6).
Hines RN, Luo Z, Hopp KA, Cabacungan ET, Koukouritaki SB, McCarver DG. | 01/21/2010 |
| FMO1 expression is restricted to the fetus; FMO1 suppression occurred within 3 d postpartum in a process tightly coupled to birth, but not gestational age. | Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression.
Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, Hines RN. | 01/21/2010 |
| FMO1 was found to be down-regulated in human adult brain tissue. | Quantitative analysis of FMO gene mRNA levels in human tissues.
Zhang J, Cashman JR. | 01/21/2010 |
| Specific allelic variants of the FMO1 gene might be associated to susceptibility to develop ALS. | Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis.
Cereda C, Gabanti E, Corato M, de Silvestri A, Alimonti D, Cova E, Malaspina A, Ceroni M, Cereda C, Gabanti E, Corato M, de Silvestri A, Alimonti D, Cova E, Malaspina A, Ceroni M. | 01/21/2010 |
| "...in fetal liver, where FMO1 predominates attaining expression levels of (about) 32% of expressed CYP3A4." p. 574 "...recent examples indicate that FMOs play a prominent role in the metabolism ...of important drugs." p. 575 | The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development.
Cashman JR. | 01/21/2010 |