| Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology. | Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology.
Burt O, Johnston KJA, Graham N, Cullen B, Lyall DM, Lyall LM, Pell JP, Ward J, Smith DJ, Strawbridge RJ., Free PMC Article | 02/12/2022 |
| Rare copy number variants in ASTN2 gene in patients with neurodevelopmental disorders. | Rare copy number variants in ASTN2 gene in patients with neurodevelopmental disorders.
Bauleo A, Montesanto A, Pace V, Brando R, De Stefano L, Puntorieri D, Cento L, Loddo S, Calacci C, Novelli A, Falcone E. | 01/22/2022 |
| Effects of rs958804 and rs7858836 single-nucleotide polymorphisms of the ASTN2 gene on pain-related phenotypes in patients who underwent laparoscopic colectomy and mandibular sagittal split ramus osteotomy. | Effects of rs958804 and rs7858836 single-nucleotide polymorphisms of the ASTN2 gene on pain-related phenotypes in patients who underwent laparoscopic colectomy and mandibular sagittal split ramus osteotomy.
Inoue R, Nishizawa D, Hasegawa J, Nakayama K, Fukuda KI, Ichinohe T, Mieda T, Tsujita M, Nakagawa H, Kitamura A, Sumikura H, Ikeda K, Hayashida M., Free PMC Article | 11/13/2021 |
| Chimeric RNA ASTN2-PAPPAas aggravates tumor progression and metastasis in human esophageal cancer. | Chimeric RNA ASTN2-PAPPA(as) aggravates tumor progression and metastasis in human esophageal cancer.
Wang L, Xiong X, Yao Z, Zhu J, Lin Y, Lin W, Li K, Xu X, Guo Y, Chen Y, Pan Y, Zhou F, Fan J, Chen Y, Gao S, Jim Yeung SC, Zhang H. | 08/21/2021 |
| ASTN2 localizes primarily to endocytic and autophagocytic vesicles in the cell soma and in subsets of dendritic spines | ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins.
Behesti H, Fore TR, Wu P, Horn Z, Leppert M, Hull C, Hatten ME., Free PMC Article | 11/17/2018 |
| Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. | Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility.
An XK, Fang J, Yu ZZ, Lin Q, Lu CX, Qu HL, Ma QL. | 04/21/2018 |
| The findings of this study do not support a major role of ASTN2 variants in ADHD or its comorbid disorders respective aADHD associated personality traits. | The role of ASTN2 variants in childhood and adult ADHD, comorbid disorders and associated personality traits.
Freitag CM, Lempp T, Nguyen TT, Jacob CP, Weissflog L, Romanos M, Renner TJ, Walitza S, Warnke A, Rujescu D, Lesch KP, Reif A. | 01/27/2018 |
| Results present the structure of ASTN-2 consisting of a combination of polypeptide folds: a perforin-like domain, a minimal epidermal growth factor-like module, a unique form of fibronectin type III domain and an annexin-like domain. Structural and biophysical data show that ASTN-2 binds inositol triphosphates, suggesting a mechanism for membrane recognition or secondary messenger regulation of its activity. | Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Ni T, Harlos K, Gilbert R., Free PMC Article | 11/25/2017 |
| The expression of coding and non-coding genes with SAFB1 cross-link sites was altered by SAFB1 knockdown. The isoform-specific expression of neural cell adhesion molecule (NCAM1) and ASTN2 was influenced by SAFB1. | iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.
Rivers C, Idris J, Scott H, Rogers M, Lee YB, Gaunt J, Phylactou L, Curk T, Campbell C, Ule J, Norman M, Uney JB., Free PMC Article | 08/27/2016 |
| Study found a significant association of ASTN2 genetic variants with age at onset in Alzheimer's disease in two independent samples together with in silico analysis that demonstrated potential role of ASTN2 in the pathogenesis of the disease | Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer's disease.
Wang KS, Tonarelli S, Luo X, Wang L, Su B, Zuo L, Mao C, Rubin L, Briones D, Xu C. | 01/16/2016 |
| rs4836732 may contribute to hip OA susceptibility by altering proximal femur shape. | Investigation of association between hip osteoarthritis susceptibility loci and radiographic proximal femur shape.
Lindner C, Thiagarajah S, Wilkinson JM, Panoutsopoulou K, Day-Williams AG, arcOGEN Consortium, Cootes TF, Wallis GA., Free PMC Article | 10/17/2015 |
| 3' terminal ASTN2 deletions are significantly enriched in males with neurodevelopmental disorders, but not in females. | Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes.
Lionel AC, Tammimies K, Vaags AK, Rosenfeld JA, Ahn JW, Merico D, Noor A, Runke CK, Pillalamarri VK, Carter MT, Gazzellone MJ, Thiruvahindrapuram B, Fagerberg C, Laulund LW, Pellecchia G, Lamoureux S, Deshpande C, Clayton-Smith J, White AC, Leather S, Trounce J, Melanie Bedford H, Hatchwell E, Eis PS, Yuen RK, Walker S, Uddin M, Geraghty MT, Nikkel SM, Tomiak EM, Fernandez BA, Soreni N, Crosbie J, Arnold PD, Schachar RJ, Roberts W, Paterson AD, So J, Szatmari P, Chrysler C, Woodbury-Smith M, Brian Lowry R, Zwaigenbaum L, Mandyam D, Wei J, Macdonald JR, Howe JL, Nalpathamkalam T, Wang Z, Tolson D, Cobb DS, Wilks TM, Sorensen MJ, Bader PI, An Y, Wu BL, Musumeci SA, Romano C, Postorivo D, Nardone AM, Monica MD, Scarano G, Zoccante L, Novara F, Zuffardi O, Ciccone R, Antona V, Carella M, Zelante L, Cavalli P, Poggiani C, Cavallari U, Argiropoulos B, Chernos J, Brasch-Andersen C, Speevak M, Fichera M, Ogilvie CM, Shen Y, Hodge JC, Talkowski ME, Stavropoulos DJ, Marshall CR, Scherer SW., Free PMC Article | 12/6/2014 |
| Single nucleotide polymorphism in ASTN2 gene is associated with cognition disorders. | Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, DeStefano AL, Lambert JC, Jack CR Jr, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM, Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth WT Jr, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium., Free PMC Article | 07/7/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 12/14/2010 |
| Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
Wang KS, Liu XF, Aragam N. | 12/5/2010 |
| Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) | Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
Adkins DE, Aberg K, McClay JL, Bukszár J, Zhao Z, Jia P, Stroup TS, Perkins D, McEvoy JP, Lieberman JA, Sullivan PF, van den Oord EJ., Free PMC Article | 04/7/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Röser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Schäfer H, Walitza S, Reif A, Stephan DA, Jacob C. | 08/12/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesConfirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.
Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W, Hui R, Wang DW. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. Recurrent CNVs disrupt three candidate genes in schizophrenia patients.
Vrijenhoek T, Buizer-Voskamp JE, van der Stelt I, Strengman E, Genetic Risk and Outcome in Psychosis (GROUP) Consortium, Sabatti C, Geurts van Kessel A, Brunner HG, Ophoff RA, Veltman JA. | 11/5/2008 |