| The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism. | The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.
van Ruiten MS, van Gent D, Sedeño Cacciatore Á, Fauster A, Willems L, Hekkelman ML, Hoekman L, Altelaar M, Haarhuis JHI, Brummelkamp TR, de Wit E, Rowland BD., Free PMC Article | 06/25/2022 |
| Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A. | Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
Wang Y, Yao J, Zhu Y, Zhao X, Lv J, Sun F., Free PMC Article | 05/21/2022 |
| PDS5A and PDS5B in Cohesin Function and Human Disease. | PDS5A and PDS5B in Cohesin Function and Human Disease.
Zhang N, Coutinho LE, Pati D., Free PMC Article | 06/26/2021 |
| PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection. | PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
Morales C, Ruiz-Torres M, Rodríguez-Acebes S, Lafarga V, Rodríguez-Corsino M, Megías D, Cisneros DA, Peters JM, Méndez J, Losada A., Free PMC Article | 09/12/2020 |
| depletion of Rad21 in a Pds5-deficient background rescues the phenotype observed upon Pds5 depletion alone. These findings support a model where loss of either component of the cohesin releasin complex perturbs cohesin dynamics on replication forks, hindering fork progression and promoting MRE11-dependent fork slowing | Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.
Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemaçon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A., Free PMC Article | 08/24/2019 |
| The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL. | Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.
Wutz G, Várnai C, Nagasaka K, Cisneros DA, Stocsits RR, Tang W, Schoenfelder S, Jessberger G, Muhar M, Hossain MJ, Walther N, Koch B, Kueblbeck M, Ellenberg J, Zuber J, Fraser P, Peters JM., Free PMC Article | 12/30/2017 |
| These results provide the first evidence indicating a tumor suppressor role of SA1 in early colon carcinogenesis | Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications.
Wali RK, Momi N, Dela Cruz M, Calderwood AH, Stypula-Cyrus Y, Almassalha L, Chhaparia A, Weber CR, Radosevich A, Tiwari AK, Latif B, Backman V, Roy HK., Free PMC Article | 12/2/2017 |
| By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion. | Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.
Minamino M, Ishibashi M, Nakato R, Akiyama K, Tanaka H, Kato Y, Negishi L, Hirota T, Sutani T, Bando M, Shirahige K. | 04/9/2016 |
| The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication. | HIV-1 infection suppresses expression of host cell cycle-associated gene PDS5A.
Capalbo G, Müller-Kuller T, Ottmann OG, Hoelzer D, Scheuring UJ. | 09/8/2012 |
| Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells. | The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.
Hagemann C, Weigelin B, Schommer S, Schulze M, Al-Jomah N, Anacker J, Gerngras S, Kühnel S, Kessler AF, Polat B, Ernestus RI, Patel R, Vince GH. | 04/23/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | [Analysis of deafness gene mutations by gene chip and its clinical significance].
Zhang H, Liu Y, Wang Y, Li G, Luo Z, Jiang Pf, Li F, Wang S, Deng K. | 06/30/2010 |
| SCC-112 improve cell proliferation and contributes to tumorigenesis by interacting with p63 and promoting cell cycling. | SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase.
Zheng MZ, Zheng LM, Zeng YX. | 01/21/2010 |
| Findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation. | SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas.
Kumar D, Sakabe I, Patel S, Zhang Y, Ahmad I, Gehan EA, Whiteside TL, Kasid U. | 01/21/2010 |