| SIK2-positive tumor epithelial cells in breast cancer maybe potential anti-cancer messengers: A systematic analysis from a single-cell perspective. | SIK2-positive tumor epithelial cells in breast cancer maybe potential anti-cancer messengers: A systematic analysis from a single-cell perspective.
Wu Q, Qu C, Xin L, Yang F, Xu L. | 01/11/2024 |
| LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition. | LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
Proteau S, Krossa I, Husser C, Guéguinou M, Sella F, Bille K, Irondelle M, Dalmasso M, Barouillet T, Cheli Y, Pisibon C, Arrighi N, Nahon-Estève S, Martel A, Gastaud L, Lassalle S, Mignen O, Brest P, Mazure NM, Bost F, Baillif S, Landreville S, Turcotte S, Hasson D, Carcamo S, Vandier C, Bernstein E, Yvan-Charvet L, Levesque MP, Ballotti R, Bertolotto C, Strub T., Free PMC Article | 12/16/2023 |
| Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes. | Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes.
Säll J, Lindahl M, Fritzen AM, Fryklund C, Kopietz F, Nyberg E, Warvsten A, Morén B, Foretz M, Kiens B, Stenkula KG, Göransson O. | 09/21/2023 |
| Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration. | Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
Lee GK, Kim HY, Park JH. | 06/30/2023 |
| SIK2 protects against renal tubular injury and the progression of diabetic kidney disease. | SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
Liu B, Zhang L, Yang H, Chen X, Zheng H, Liao X. | 02/4/2023 |
| SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK. | SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
Shi X, Yu X, Wang J, Bian S, Li Q, Fu F, Zou X, Zhang L, Bast RC Jr, Lu Z, Guo L, Chen Y, Zhou J., Free PMC Article | 07/9/2022 |
| SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/beta-catenin signaling. | SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling.
Rong Z, Zhang L, Li Z, Xiao Z, Duan Y, Ren X, Zi Y, Gao J, Mu Y, Guan Y, Cao Z, Wang X, Pei Q, Zeng Y, Fan Q, Zeng Z, Ou D, He J, Nie Y, Tan R, Weng L, Li Y, Xiang R, Deng Y, Sun L. | 05/7/2022 |
| SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells. | SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells.
Chan KK, Abdul-Sater Z, Sheth A, Mitchell DK, Sharma R, Edwards DM, He Y, Nalepa G, Rhodes SD, Clapp DW, Sierra Potchanant EA., Free PMC Article | 04/16/2022 |
| LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression. | LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression.
Huang J, Lin F, Xu C, Xu Y. | 03/26/2022 |
| Role of saltinducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells. | Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.
Ni X, Feng Y, Fu X., Free PMC Article | 01/22/2022 |
| SIK2 orchestrates actin-dependent host response upon Salmonella infection. | SIK2 orchestrates actin-dependent host response upon Salmonella infection.
Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C, Dikic I., Free PMC Article | 12/11/2021 |
| JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes. | JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes.
Negoita F, Vavakova M, Säll J, Laurencikiene J, Göransson O. | 12/4/2021 |
| Salt-inducible kinase 2 functions as a tumor suppressor in hepatocellular carcinoma. | Salt-inducible kinase 2 functions as a tumor suppressor in hepatocellular carcinoma.
Li Y, Yu J, Jia M, Ma P, Dong C. | 11/22/2021 |
| SIK2 represses AKT/GSK3beta/beta-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases. | SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases.
Dai XM, Zhang YH, Lin XH, Huang XX, Zhang Y, Xue CR, Chen WN, Ye JX, Lin XJ, Lin X., Free PMC Article | 11/22/2021 |
| Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human beta cell proliferation. | Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.
Iorio C, Rourke JL, Wells L, Sakamaki JI, Moon E, Hu Q, Kin T, Screaton RA., Free PMC Article | 11/13/2021 |
| High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms. | High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms.
Jin HY, Tudor Y, Choi K, Shao Z, Sparling BA, McGivern JG, Symons A. | 07/17/2021 |
| Tumor-suppressor Fbxw7 targets SIK2 for degradation to interfere with TORC2-AKT signaling in pancreatic cancer. | Tumor-suppressor Fbxw7 targets SIK2 for degradation to interfere with TORC2-AKT signaling in pancreatic cancer.
Zhang MX, Wang H, Sun GP. | 06/26/2021 |
| SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway. | SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway.
Zhao J, Zhang X, Gao T, Wang S, Hou Y, Yuan P, Yang Y, Yang T, Xing J, Li J, Liu S., Free PMC Article | 01/16/2021 |
| Salt-inducible Kinases Are Critical Determinants of Female Fertility. | Salt-inducible Kinases Are Critical Determinants of Female Fertility.
Armouti M, Winston N, Hatano O, Hobeika E, Hirshfeld-Cytron J, Liebermann J, Takemori H, Stocco C., Free PMC Article | 12/19/2020 |
| Salt-inducible kinases (SIKs) regulate TGFbeta-mediated transcriptional and apoptotic responses. | Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.
Hutchinson LD, Darling NJ, Nicolaou S, Gori I, Squair DR, Cohen P, Hill CS, Sapkota GP., Free PMC Article | 11/21/2020 |
| In ovarian cancer (OC) cells SIK2 upregulated the expression of HIF-1alpha by activating the PI3K/AKT signaling pathway, which directly upregulated the transcription of major glycolytic genes to promote glycolysis and promoted mitochondrial fission through phosphorylation of Drp1 at Ser616 site, which inhibited the mitochondrial oxidative phosphorylation. SIK2 promoted growth and metastasis of OC cells. | SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer.
Gao T, Zhang X, Zhao J, Zhou F, Wang Y, Zhao Z, Xing J, Chen B, Li J, Liu S. | 07/4/2020 |
| Parathyroid hormone can affect the osteogenesis process of adipose tissue stem cells by regulating SIK2 and Wnt4. | Parathyroid hormone (PTH) promotes ADSC osteogenesis by regulating SIK2 and Wnt4.
An Y, Zhao J, Nie F, Wu Y, Xia Y, Li D. | 07/4/2020 |
| Data suggest that cAMP/protein kinase A-dependent phosphorylation of SIK1, SIK2, and SIK3 inhibits their catalytic activity by inducing 14-3-3 protein binding. | 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).
Sonntag T, Vaughan JM, Montminy M., Free PMC Article | 12/22/2018 |
| results of this study indicate that SIK2 expression can serve as a prognostic biomarker for EOC and that miR-874-3p and miR-874-5p have the potential to enhance clinical treatment of EOC | Upregulation of miR-874-3p and miR-874-5p inhibits epithelial ovarian cancer malignancy via SIK2.
Xia B, Lin M, Dong W, Chen H, Li B, Zhang X, Hou Y, Lou G. | 09/29/2018 |
| SIK2 controls osteocyte responses to parathyroid hormone. | SIKs control osteocyte responses to parathyroid hormone.
Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM., Free PMC Article | 08/25/2018 |