| To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice | Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.
Shemesh CS, Yu RZ, Gaus HJ, Seth PP, Swayze EE, Bennett FC, Geary RS, Henry SP, Wang Y. | 02/3/2018 |
| A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. | Hepcidin bound to α2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels.
Huang ML, Austin CJD, Sari MA, Suryo Rahmanto Y, Ponka P, Vyoral D, Richardson DR., Free PMC Article | 12/14/2013 |
| Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase. | Modification of mouse A2M B (620-792) and A2M N (168-230) by malondialdehyde and acetaldehyde attenuates the proteinase and TGF-β1 binding ability of A2MB.
Kaur I, Katyal A. | 05/21/2011 |
| MMP9 production promoted by the alpha(2)M*/LRP1 interaction required the activation of both MAPK-ERK1/2 and NF-kappaB signaling pathways. | Activated α(2) macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines.
Cáceres LC, Bonacci GR, Sánchez MC, Chiabrando GA. | 02/5/2011 |
| Prion protein paralog doppel protein interacts with alpha-2-macroglobulin | Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration.
Benvegnù S, Franciotta D, Sussman J, Bachi A, Zardini E, Torreri P, Govaerts C, Pizzo S, Legname G., Free PMC Article | 01/21/2010 |
| the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind | Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?
Arnold JN, Wallis R, Willis AC, Harvey DJ, Royle L, Dwek RA, Rudd PM, Sim RB. | 01/21/2010 |
| Data describe the role of the PI3-kinase/PDK/Akt/p70s6k signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB in these events. | Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.
Misra UK, Pizzo SV. | 01/21/2010 |
| review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy. | Functions of alpha 2 macroglobulins in pregnancy.
Tayade C, Esadeg S, Fang Y, Croy BA. | 01/21/2010 |
| IL-11 signals through the Jak2/Stat3 pathway in decidual cells to stimulate the expression of alpha(2)-MG, a protease inhibitor essential for normal placentation in pregnancy. | The role of interleukin-11 in pregnancy involves up-regulation of alpha2-macroglobulin gene through janus kinase 2-signal transducer and activator of transcription 3 pathway in the decidua.
Bao L, Devi YS, Bowen-Shauver J, Ferguson-Gottschall S, Robb L, Gibori G. | 01/21/2010 |
| the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents | Characterization of a murine alpha 2 macroglobulin gene expressed in reproductive and cardiovascular tissue.
He H, McCartney DJ, Wei Q, Esadeg S, Zhang J, Foster RA, Hayes MA, Tayade C, Van Leuven F, Croy BA. | 01/21/2010 |
| PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit | Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1.
Arandjelovic S, Van Sant CL, Gonias SL. | 01/21/2010 |
| Alpha2 macroglobulin requires cyclic amp and signal transduction for cell growth | The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
Misra UK, Akabani G, Pizzo SV. | 01/21/2010 |
| Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. | Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.
Waghabi MC, Coutinho CM, Soeiro MN, Pereira MC, Feige JJ, Keramidas M, Cosson A, Minoprio P, Van Leuven F, Araújo-Jorge TC., Free PMC Article | 01/21/2010 |