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    FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 2321, updated on 8-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer.

    Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer.
    Figueroa L, Rosas M, Alvarez M, Aguilar E, Mateu V, Bonilla E.

    10/8/2024
    FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer.

    FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer.
    Tai Y, Chow A, Han S, Coker C, Ma W, Gu Y, Estrada Navarro V, Kandpal M, Hibshoosh H, Kalinsky K, Manova-Todorova K, Safonov A, Walsh EM, Robson M, Norton L, Baer R, Merghoub T, Biswas AK, Acharyya S., Free PMC Article

    09/23/2024
    Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.

    Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
    García-Domínguez DJ, Hajji N, Sánchez-Molina S, Figuerola-Bou E, de Pablos RM, Espinosa-Oliva AM, Andrés-León E, Terrón-Camero LC, Flores-Campos R, Pascual-Pasto G, Robles MJ, Machado I, Llombart-Bosch A, Magagnoli G, Scotlandi K, Carcaboso ÁM, Mora J, de Álava E, Hontecillas-Prieto L., Free PMC Article

    08/28/2024
    Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.

    Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages.
    Tanaka H, Ozawa R, Henmi Y, Hosoda M, Karasawa T, Takahashi M, Takahashi H, Iwata H, Kuwayama T, Shirasuna K.

    04/2/2024
    Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.

    Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.
    Vogtmann R, Riedel A, Sassmannshausen I, Langer S, Kühnel-Terjung E, Kimmig R, Schorle H, Winterhager E, Gellhaus A., Free PMC Article

    03/13/2024
    A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.

    A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells.
    Kinghorn K, Gill A, Marvin A, Li R, Quigley K, Singh S, Gore MT, le Noble F, Gabhann FM, Bautch VL., Free PMC Article

    02/22/2024
    Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.

    Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.
    Sarabipour S, Kinghorn K, Quigley KM, Kovacs-Kasa A, Annex BH, Bautch VL, Mac Gabhann F., Free PMC Article

    02/21/2024
    Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.

    Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension.
    Ma H, Wang C, Jiang M, Jin K, Xu T, Wang Z, Xu J, Ni L, Shi H, Shen P, Chen Y, Feng X, Zhang W.

    02/8/2024
    Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.

    Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents.
    Theerathananon W, Watanapa WB, Wataganara T, Pratumvinit B, Rahman S.

    02/6/2024
    SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.

    SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
    Xu K, Fei W, Gao W, Fan C, Li Y, Hong Y, Cui R.

    01/29/2024
    Reference Interval of Soluble FMS-like Tyrosine Kinase-1 in Non-Pregnant and Pregnant Females: A Novel Biomarker for Pre-eclampsia.

    Reference Interval of Soluble FMS‑like Tyrosine Kinase‑1 in Non-Pregnant and Pregnant Females: A Novel Biomarker for Pre-eclampsia.
    Ahmed AR, Khan MD, Batool H, Chughtai O, Chughtai AS, Sarwar S.

    01/4/2024
    High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia.

    High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia.
    Aisagbonhi O, Bui T, Nasamran CA, St Louis H, Pizzo D, Meads M, Mulholland M, Magallanes C, Lamale-Smith L, Laurent LC, Morey R, Jacobs MB, Fisch KM, Horii M., Free PMC Article

    12/20/2023
    Wnt5a-Flt1 activation contributes to preterm altered cerebral angiogenesis after prenatal inflammation.

    Wnt5a-Flt1 activation contributes to preterm altered cerebral angiogenesis after prenatal inflammation.
    Jiangxue H, Liling Y, Fang X, Shumei Y, Gengying L, Xuejun R, Yao Y, Chuan N, Jie Y, Zhuxiao R.

    10/11/2023
    Accuracy of placental growth factor alone or in combination with soluble fms-like tyrosine kinase-1 or maternal factors in detecting preeclampsia in asymptomatic women in the second and third trimesters: a systematic review and meta-analysis.

    Accuracy of placental growth factor alone or in combination with soluble fms-like tyrosine kinase-1 or maternal factors in detecting preeclampsia in asymptomatic women in the second and third trimesters: a systematic review and meta-analysis.
    Chaemsaithong P, Gil MM, Chaiyasit N, Cuenca-Gomez D, Plasencia W, Rolle V, Poon LC.

    08/30/2023
    sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies-A Review of the Literature.

    sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies-A Review of the Literature.
    Sapantzoglou I, Rouvali A, Koutras A, Chatziioannou MI, Prokopakis I, Fasoulakis Z, Zachariou E, Douligeris A, Mortaki A, Perros P, Ntounis T, Pergialiotis V, Domali E, Athanasiou S, Daskalakis G, Rodolakis A, Panagopoulos P, Pappa KI., Free PMC Article

    08/3/2023
    Vascular endothelial growth factor receptor 1 gene (FLT1) longevity variant increases lifespan by reducing mortality risk posed by hypertension.

    Vascular endothelial growth factor receptor 1 gene (FLT1) longevity variant increases lifespan by reducing mortality risk posed by hypertension.
    Morris BJ, Chen R, Donlon TA, Kallianpur KJ, Masaki KH, Willcox BJ., Free PMC Article

    06/13/2023
    Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages.

    Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages.
    Liu X, Li Z, Sun J, Zhang Z, Li W., Free PMC Article

    03/29/2023
    The Soluble Fms-like Tyrosine Kinase-1 Contributes to Structural and Functional Changes in Endothelial Cells in Chronic Kidney Disease.

    The Soluble Fms-like Tyrosine Kinase-1 Contributes to Structural and Functional Changes in Endothelial Cells in Chronic Kidney Disease.
    Schulz A, Drost CC, Hesse B, Beul K, Brand M, Di Marco GS., Free PMC Article

    01/11/2023
    sFlt-1 in Chronic Kidney Disease: Friend or Foe?

    sFlt-1 in Chronic Kidney Disease: Friend or Foe?
    Matsui M, Onoue K, Saito Y., Free PMC Article

    12/10/2022
    Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder.

    Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder.
    Lumbanraja S, Yaznil MR, Siahaan AM, Berry Eka Parda B., Free PMC Article

    10/8/2022
    MiR-30a-3p Targeting FLT1 Modulates Trophoblast Cell Proliferation in the Pathogenesis of Preeclampsia.

    MiR-30a-3p Targeting FLT1 Modulates Trophoblast Cell Proliferation in the Pathogenesis of Preeclampsia.
    Wang Y, Wang L, Yu X, Gong W.

    09/24/2022
    sFlt-1 value predicts pregnancy prolongation periods from diagnosis in pregnant women diagnosed with early-onset preeclampsia.

    sFlt-1 value predicts pregnancy prolongation periods from diagnosis in pregnant women diagnosed with early-onset preeclampsia.
    Tanaka H, Nagahashi Y, Toriyabe K, Maki S, Takakura S, Enomoto N, Tanaka K, Shinji K, Ikeda T.

    09/3/2022
    Associations Between Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia.

    Associations Between Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia.
    Hastie R, Bergman L, Walker SP, Kaitu'u-Lino T, Hannan NJ, Brownfoot F, Schell S, Harper A, Cannon P, Cluver CA, Tong S., Free PMC Article

    08/27/2022
    [Association of polymorphisms of VEGF and VEGFR1 pathways related genes and risk of pre-eclampsia].

    [Association of polymorphisms of VEGF and VEGFR1 pathways related genes and risk of pre-eclampsia].
    Li L, Guo X, Chen B, Gao Z, Liu J, Wang Q.

    08/13/2022
    The effect of comorbidities on the sFLT-1:PlGF ratio in preeclampsia.

    The effect of comorbidities on the sFLT-1:PlGF ratio in preeclampsia.
    Tanner MS, de Guingand D, Reddy M, Rowson S, Rolnik DL, Davey MA, Mol BW, Wallace EM, Da Silva Costa F, Palmer KR.

    08/13/2022
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