| Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment. | Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.
Sheridan SD, Horng JE, Yeh H, McCrea L, Wang J, Fu T, Perlis RH., | 03/18/2024 |
| Integrated machine learning-driven disulfidptosis profiling: CYFIP1 and EMILIN1 as therapeutic nodes in neuroblastoma. | Integrated machine learning-driven disulfidptosis profiling: CYFIP1 and EMILIN1 as therapeutic nodes in neuroblastoma.
Mengzhen Z, Xinwei H, Zeheng T, Nan L, Yang Y, Huirong Y, Kaisi F, Xiaoting D, Liucheng Y, Kai W., Free PMC Article | 03/5/2024 |
| Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia. | Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.
Peng X, Wellard N, Ghosh A, Troakes C, Giese KP. | 01/17/2024 |
| Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders. | Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.
Biembengut ÍV, Silva ILZ, Souza TACB, Shigunov P. | 01/29/2022 |
| Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. | Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms.
Haan N, Westacott LJ, Carter J, Owen MJ, Gray WP, Hall J, Wilkinson LS., Free PMC Article | 07/24/2021 |
| Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders. | Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders.
Sledziowska M, Galloway J, Baudouin SJ. | 06/19/2021 |
| The human studies revealed profound deficits in grammatical reasoning, arithmetic reasoning, and working memory in BP1-BP2 (TUBGCP5, CYFIP1, NIPA2, and NIPA1) deletion carriers. | Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage.
Woo YJ, Kanellopoulos AK, Hemati P, Kirschen J, Nebel RA, Wang T, Bagni C, Abrahams BS., Free PMC Article | 07/4/2020 |
| this research identifies the behavioral and molecular consequences of CYFIP1 overexpression. | CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes.
Fricano-Kugler C, Gordon A, Shin G, Gao K, Nguyen J, Berg J, Starks M, Geschwind DH., Free PMC Article | 06/20/2020 |
| Surprisingly, Rac1 is not located at the binding site on the Sra1 subunit of the WAVE regulatory complex previously identified by mutagenesis and biochemical data. Rather, it binds to a distinct, conserved site on the opposite end of Sra1. | Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites.
Chen B, Chou HT, Brautigam CA, Xing W, Yang S, Henry L, Doolittle LK, Walz T, Rosen MK., Free PMC Article | 05/6/2020 |
| The current study provides further supports for contribution of CYFIP1/2 in the pathogenesis of autism spectrum disorder (ASD) and potentiates it as a peripheral marker for ASD diagnosis. | Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.
Noroozi R, Omrani MD, Sayad A, Taheri M, Ghafouri-Fard S. | 07/27/2019 |
| The expression level of Cyfip1 mRNA was significantly lower in patients with nasopharyngeal carcinoma than in the control samples. Low expression level of Cyfip1 mRNA was significantly associated with invasive range, lymph node metastasis, distant metastases, and clinical stage. | Low expression of Cyfip1 may be a potential biomarker in nasopharyngeal carcinoma.
Shi X, Chen X, Li WC, Mo LJ, Lin ZY, Li YY, Yang Z, Mo WN. | 06/29/2019 |
| A novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7-CYFIP1-mediated signaling pathways. | Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway.
Chang JW, Kuo WH, Lin CM, Chen WL, Chan SH, Chiu MF, Chang IS, Jiang SS, Tsai FY, Chen CH, Huang PH, Chang KJ, Lin KT, Lin SC, Wang MY, Uen YH, Tu CW, Hou MF, Tsai SF, Shen CY, Tung SL, Wang LH., Free PMC Article | 03/2/2019 |
| CYFIP1 gene expression was upregulated in the blood of epileptic patients. | Expression Analysis of CYFIP1 and CAMKK2 Genes in the Blood of Epileptic and Schizophrenic Patients.
Sayad A, Ranjbaran F, Ghafouri-Fard S, Arsang-Jang S, Taheri M. | 11/3/2018 |
| The studies suggest that MNK-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1. (Review) | Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK-eIF4E Axis.
Bramham CR, Jensen KB, Proud CG. | 08/5/2017 |
| rs4778298, a common variant at CYFIP1 is associated with inter-individual variation in surface area across the left supramarginal gyrus. | A Common CYFIP1 Variant at the 15q11.2 Disease Locus Is Associated with Structural Variation at the Language-Related Left Supramarginal Gyrus.
Woo YJ, Wang T, Guadalupe T, Nebel RA, Vino A, Del Bene VA, Molholm S, Ross LA, Zwiers MP, Fisher SE, Foxe JJ, Abrahams BS., Free PMC Article | 07/29/2017 |
| we show that stapled peptides targeting the interface between NCKAP1 and CYFIP1 destabilize the WASF3 complex... thereby suppressing invasion and metastasis of breast cancer cells. | The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis.
Teng Y, Qin H, Bahassan A, Bendzunas NG, Kennedy EJ, Cowell JK., Free PMC Article | 07/29/2017 |
| Both mRNA and protein expression levels of Cyfip1 were significantly lower in ALL patients. | Cyfip1 is downregulated in acute lymphoblastic leukemia and may be a potential biomarker in acute lymphoblastic leukemia.
Chen X, Qin L, Li P, Mo W. | 02/18/2017 |
| Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks. | Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks.
Nebel RA, Zhao D, Pedrosa E, Kirschen J, Lachman HM, Zheng D, Abrahams BS., Free PMC Article | 07/16/2016 |
| Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly. | Cyfip1 Regulates Presynaptic Activity during Development.
Hsiao K, Harony-Nicolas H, Buxbaum JD, Bozdagi-Gunal O, Benson DL., Free PMC Article | 06/28/2016 |
| Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time | Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR.
Oguro-Ando A, Rosensweig C, Herman E, Nishimura Y, Werling D, Bill BR, Berg JM, Gao F, Coppola G, Abrahams BS, Geschwind DH., Free PMC Article | 06/11/2016 |
| This study confirmed that CYFIP2 were altered in postsynaptic density in patient with schizophrenia. | Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.
Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cagney G, Cotter DR. | 12/12/2015 |
| haploinsufficiency causes cell polarity defects via WAVE complex destabilization; genetic polymorphism is associated with schizophrenia | Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
Yoon KJ, Nguyen HN, Ursini G, Zhang F, Kim NS, Wen Z, Makri G, Nauen D, Shin JH, Park Y, Chung R, Pekle E, Zhang C, Towe M, Hussaini SM, Lee Y, Rujescu D, St Clair D, Kleinman JE, Hyde TM, Krauss G, Christian KM, Rapoport JL, Weinberger DR, Song H, Ming GL., Free PMC Article | 05/16/2015 |
| An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders. | Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders.
Waltes R, Duketis E, Knapp M, Anney RJ, Huguet G, Schlitt S, Jarczok TA, Sachse M, Kämpfer LM, Kleinböck T, Poustka F, Bölte S, Schmötzer G, Voran A, Huy E, Meyer J, Bourgeron T, Klauck SM, Freitag CM, Chiocchetti AG. | 06/28/2014 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Confirmed rare copy number variants implicate novel genes in schizophrenia.
Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MD, Malloy MP, Muir WJ, Pickard BS, Deary IJ, Blackwood DH, Carter NP, Grant SG. | 06/30/2010 |
| Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the trans-golgi network. | Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.
Anitei M, Stange C, Parshina I, Baust T, Schenck A, Raposo G, Kirchhausen T, Hoflack B., Free PMC Article | 05/3/2010 |