| GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage. | GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage.
Vcelkova T, Reiter W, Zylka M, Hollenstein DM, Schuckert S, Hartl M, Seiser C., Free PMC Article | 12/1/2023 |
| Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank. | Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank.
Wells HRR, Abidin FNZ, Freidin MB, Williams FMK, Dawson SJ., Free PMC Article | 10/16/2021 |
| Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex. | Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.
Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR., Free PMC Article | 03/20/2021 |
| Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. | Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW., Free PMC Article | 01/2/2021 |
| RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells. | RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells.
Xiang Z, Zhou S, Liang S, Zhang G, Tan Y. | 12/26/2020 |
| MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex. | MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex.
Chen K, Cai Y, Cheng C, Zhang J, Lv F, Xu G, Duan P, Wu Y, Wu Z. | 11/28/2020 |
| Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate. | Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Kim SA, Zhu J, Yennawar N, Eek P, Tan S., Free PMC Article | 09/19/2020 |
| AGS mutations in this cluster impair the interaction of RNase H2 with several members of the CoREST chromatin-silencing complex that include the histone deacetylase HDAC2 and the demethylase KDM1A, the transcriptional regulators RCOR1 and GTFII-I as well as ZMYM3, an MYM-type zinc finger protein. | Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex.
Shapson-Coe A, Valeiras B, Wall C, Rada C., Free PMC Article | 12/7/2019 |
| The studies have identified members of the CoREST repression complex as key regulators of HIV latency in microglia. | HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.
Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM., Free PMC Article | 11/30/2019 |
| This study showed that tetrahydrofolate stably binds to the LSD1/CoREST complex, in its open conformation, at its entrance. | Exploring the Active Center of the LSD1/CoREST Complex by Molecular Dynamics Simulation Utilizing Its Co-crystallized Co-factor Tetrahydrofolate as a Probe.
Zalloum WA, Zalloum HM. | 10/20/2018 |
| the intact CoREST complex is targeted with dual histone deacetylase and demethylase inhibitors | Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA., Free PMC Article | 03/24/2018 |
| This study identified histone modification by SUMO as the first post-translational modification that stimulates intranucleosomal demethylation by the developmentally critical LSD1-CoREST complex. | Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex.
Dhall A, Weller CE, Chu A, Shelton PMM, Chatterjee C., Free PMC Article | 10/14/2017 |
| results demonstrate that CoREST and LSD1 downregulate the Notch pathway in the developing cerebral cortex | The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development.
Lopez CI, Saud KE, Aguilar R, Berndt FA, Cánovas J, Montecino M, Kukuljan M. | 10/7/2017 |
| ERalpha engages not only LSD1, but its partners of the CoREST corepressor complex and the molecular chaperone Hsp90. | LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP.
Bennesch MA, Segala G, Wider D, Picard D., Free PMC Article | 06/10/2017 |
| Expressions of REST and RCOR1 genes may downregulate SYN1 expression in gliomas. | Expression profiling of RE1-silencing transcription factor (REST), REST corepressor 1 (RCOR1), and Synapsin 1 (SYN1) genes in human gliomas.
Yucebas M, Yilmaz Susluer S, Onur Caglar H, Balci T, Dogan Sigva ZO, Akalin T, Oktar N, Dalbasti T, Biray Avci C, Gunduz C. | 03/4/2017 |
| Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion. | The Corepressor Rcor1 Is Essential for Normal Myeloerythroid Lineage Differentiation.
Yao H, Goldman DC, Fan G, Mandel G, Fleming WH., Free PMC Article | 08/6/2016 |
| The results suggest that LSD1/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate. | Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex.
Kim SA, Chatterjee N, Jennings MJ, Bartholomew B, Tan S., Free PMC Article | 08/22/2015 |
| results suggest that LSD1-CoREST functions as an ergonomic clamp that induces the detachment of the H3 histone tail from the nucleosomal DNA to make it available for capture by the enzyme active site. | Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.
Pilotto S, Speranzini V, Tortorici M, Durand D, Fish A, Valente S, Forneris F, Mai A, Sixma TK, Vachette P, Mattevi A., Free PMC Article | 05/9/2015 |
| Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients. | An RCOR1 loss-associated gene expression signature identifies a prognostically significant DLBCL subgroup.
Chan FC, Telenius A, Healy S, Ben-Neriah S, Mottok A, Lim R, Drake M, Hu S, Ding J, Ha G, Scott DW, Kridel R, Bashashati A, Rogic S, Johnson N, Morin RD, Rimsza LM, Sehn L, Connors JM, Marra MA, Gascoyne RD, Shah SP, Steidl C. | 04/25/2015 |
| a combination of virtual screening and biological approaches can lead to compounds reducing REST complex formation | Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models.
Conforti P, Zuccato C, Gaudenzi G, Ieraci A, Camnasio S, Buckley NJ, Mutti C, Cotelli F, Contini A, Cattaneo E. | 11/23/2013 |
| Data show that miR-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 and HDAC4 mRNAs. | MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.
Jovicic A, Zaldivar Jolissaint JF, Moser R, Silva Santos Mde F, Luthi-Carter R., Free PMC Article | 07/27/2013 |
| Gfi-1B p32 isoform binds to Gfi-1B target gene promoters and associates with the LSD1-CoREST repressor complex more efficiently than the major Gfi-1B p37 isoform | A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.
Laurent B, Randrianarison-Huetz V, Frisan E, Andrieu-Soler C, Soler E, Fontenay M, Dusanter-Fourt I, Duménil D. | 04/6/2013 |
| the H3 binding pocket is a central target site to (i) switch off LSD1 amino oxidase activity, thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii) prevent chromatin anchoring to LSD1/CoREST. | LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.
Baron R, Vellore NA., Free PMC Article | 10/27/2012 |
| The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes. | The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes.
Zhou G, Te D, Roizman B., Free PMC Article | 09/3/2011 |
| Transciption factor SNAIL1 mimics the histone H3 tail and binds to the histone demethylase LSD1-transcription co-repressor (CoREST) complex. The crystal structure of the complex is given here. | Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.
Baron R, Binda C, Tortorici M, McCammon JA, Mattevi A., Free PMC Article | 07/2/2011 |