| Do PACS1 variants impeding adaptor protein binding predispose to syndromic intellectual disability? | Do PACS1 variants impeding adaptor protein binding predispose to syndromic intellectual disability?
Moller-Hansen A, Hejla D, Lee HK, Lyles JB, Yang Y, Chen K, Li WL, Thomas G, Boerkoel CF., Free PMC Article | 09/12/2023 |
| Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting. | Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.
Doray B, Liu L, Lee WS, Jennings BC, Kornfeld S., Free PMC Article | 12/18/2021 |
| GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D2 in a Rab4-dependent mechanism. | GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.
Fréchette L, Binda C, Génier S, Degrandmaison J, Boisvert M, Parent JL. | 08/7/2021 |
| SNPs: rs6414624 in EVC and rs78338345 in GGA3 are novel susceptibility loci for type 2 diabetes mellitus in Japanese individuals. | Two novel susceptibility loci for type 2 diabetes mellitus identified by longitudinal exome-wide association studies in a Japanese population.
Yasukochi Y, Sakuma J, Takeuchi I, Kato K, Oguri M, Fujimaki T, Horibe H, Yamada Y. | 04/20/2019 |
| In the absence of GGA3, integrins are increasingly retained inside the cell, traffic toward the perinuclear lysosomal compartment and their degradation is enhanced. | Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.
Ratcliffe CD, Sahgal P, Parachoniak CA, Ivaska J, Park M. | 09/2/2017 |
| This work identifies GGA3 as a key player in a novel DXXLL-mediated endosomal sorting machinery that targets TrkA to the plasma membrane, where it prolongs the activation of Akt signaling and survival responses. | GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.
Li X, Lavigne P, Lavoie C., Free PMC Article | 10/22/2016 |
| role of GGA3 in the cell surface export of alpha2B-adrenergic receptor | GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.
Zhang M, Davis JE, Li C, Gao J, Huang W, Lambert NA, Terry AV Jr, Wu G., Free PMC Article | 08/13/2016 |
| These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. | Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.
Stahlschmidt W, Robertson MJ, Robinson PJ, McCluskey A, Haucke V., Free PMC Article | 04/26/2014 |
| GGA3 is involved in the cellular processes relevant for Alzheimer's disease pathogenesis. | Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. | 04/12/2014 |
| Subcellular fractionation of Alzheimer's disease cortex with low levels of Golgi-localized GGA proteins shows an alteration of beta-secretase distribution and extensive co-localization with amyloid beta precursor protein APP. | Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein.
Santosa C, Rasche S, Barakat A, Bellingham SA, Ho M, Tan J, Hill AF, Masters CL, McLean C, Evin G. | 04/14/2012 |
| GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery | Ubiquitin regulates GGA3-mediated degradation of BACE1.
Kang EL, Cameron AN, Piazza F, Walker KR, Tesco G., Free PMC Article | 09/20/2010 |
| seladin-1 downregulation increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis | Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, Hiltunen M., Free PMC Article | 01/21/2010 |
| GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs. | Defects in cellular sorting and retroviral assembly induced by GGA overexpression.
Joshi A, Nagashima K, Freed EO., Free PMC Article | 01/21/2010 |
| These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network. | PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.
Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL., Free PMC Article | 01/21/2010 |
| crystal structure of the GAT domain | Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins.
Prag G, Lee S, Mattera R, Arighi CN, Beach BM, Bonifacino JS, Hurley JH., Free PMC Article | 01/21/2010 |
| RNAi of GGA3 expression results in accumulation of the cation-independent mannose 6-phosphate receptor and internalized epidermal growth factor (EGF) within enlarged early endosomes. This perturbation impairs the degradation of internalized EGF. | Interactions of GGA3 with the ubiquitin sorting machinery.
Puertollano R, Bonifacino JS. | 01/21/2010 |
| structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors | Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.
Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH. | 01/21/2010 |
| found that the human GGA3 protein GAT domain contains two ubiquitin binding motifs that bind to the same surface of ubiquitin | The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs.
Bilodeau PS, Winistorfer SC, Allaman MM, Surendhran K, Kearney WR, Robertson AD, Piper RC., Free PMC Article | 01/21/2010 |
| GGA3, becomes transiently phosphorylated upon activation of the epidermal growth factor (EGF) receptor. (GGA3) | Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.
Kametaka S, Mattera R, Bonifacino JS., Free PMC Article | 01/21/2010 |
| ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18 | Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.
Yogosawa S, Kawasaki M, Wakatsuki S, Kominami E, Shiba Y, Nakayama K, Kohsaka S, Akazawa C. | 01/21/2010 |
| These results indicate that GGA3-S is predominantly expressed in human tissues except the brain and in cell lines. | Predominant expression of the short form of GGA3 in human cell lines and tissues.
Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y. | 01/21/2010 |
| CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported. | A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.
Scott GK, Fei H, Thomas L, Medigeshi GR, Thomas G., Free PMC Article | 01/21/2010 |
| GGA proteins funstion with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface. | GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
He X, Li F, Chang WP, Tang J. | 01/21/2010 |
| We have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD. | Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE., Free PMC Article | 01/21/2010 |