| LncRNA AFAP1-AS1 Knockdown Represses Cell Proliferation, Migration, and Induced Apoptosis in Breast Cancer by Downregulating SEPT2 Via Sponging miR-497-5p. | LncRNA AFAP1-AS1 Knockdown Represses Cell Proliferation, Migration, and Induced Apoptosis in Breast Cancer by Downregulating SEPT2 Via Sponging miR-497-5p.
Cai B, Wang X, Bu Q, Li P, Xue Q, Zhang J, Ding P, Sun D. | 10/29/2022 |
| LSD1-mediated stabilization of SEPT6 protein activates the TGF-beta1 pathway and regulates non-small-cell lung cancer metastasis. | LSD1-mediated stabilization of SEPT6 protein activates the TGF-β1 pathway and regulates non-small-cell lung cancer metastasis.
Hong Y, Li X, Zhu J. | 04/9/2022 |
| SEPT6 drives hepatocellular carcinoma cell proliferation, migration and invasion via the Hippo/YAP signaling pathway. | SEPT6 drives hepatocellular carcinoma cell proliferation, migration and invasion via the Hippo/YAP signaling pathway.
Fan Y, Du Z, Ding Q, Zhang J, Op Den Winkel M, Gerbes AL, Liu M, Steib CJ., Free PMC Article | 11/27/2021 |
| An atomic model for the human septin hexamer by cryo-EM. | An atomic model for the human septin hexamer by cryo-EM.
Mendonça DC, Guimarães SL, Pereira HD, Pinto AA, de Farias MA, de Godoy AS, Araujo APU, van Heel M, Portugal RV, Garratt RC. | 09/25/2021 |
| Orientational Ambiguity in Septin Coiled Coils and its Structural Basis. | Orientational Ambiguity in Septin Coiled Coils and its Structural Basis.
Leonardo DA, Cavini IA, Sala FA, Mendonça DC, Rosa HVD, Kumagai PS, Crusca E Jr, Valadares NF, Marques IA, Brandão-Neto J, Munte CE, Kalbitzer HR, Soler N, Usón I, André I, Araujo APU, D'Muniz Pereira H, Garratt RC. | 06/26/2021 |
| Molecular Recognition at Septin Interfaces: The Switches Hold the Key. | Molecular Recognition at Septin Interfaces: The Switches Hold the Key.
Rosa HVD, Leonardo DA, Brognara G, Brandão-Neto J, D'Muniz Pereira H, Araújo APU, Garratt RC. | 03/6/2021 |
| Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis. | Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
Collins KB, Kang H, Matsche J, Klomp JE, Rehman J, Malik AB, Karginov AV., Free PMC Article | 09/19/2020 |
| regulates various biological behaviors in hepatic stellate cells through TGF-beta1/Smad, mitogen-activated protein kinases and phosphatidylinositol-3-kinase/protein kinase B signaling pathways, thus promoting liver fibrosis | Effect of SEPT6 on the biological behavior of hepatic stellate cells and liver fibrosis in rats and its mechanism.
Fan Y, Du Z, Steib CJ, Ding Q, Lu P, Tian D, Liu M. | 07/20/2019 |
| Results demonstrate that in stored platelets, septine-2 and septin-6 mRNAs have miR- 223 target sites, septin-2 and septin-6 are in complex with Ago-2. The results demonstrate that like in nucleated cells, enucleated platelets also have microRNA-based mechanisms for the regulation of their septins. | MicroRNA-223 Regulates Septin-2 and Septin-6 in Stored Platelets.
Chattopadhyay M, Dahiya N, Atreya C. | 12/22/2018 |
| SUMOylation of human septins is critical for septin filament bundling and cytokinesis. | SUMOylation of human septins is critical for septin filament bundling and cytokinesis.
Ribet D, Boscaini S, Cauvin C, Siguier M, Mostowy S, Echard A, Cossart P., Free PMC Article | 12/9/2017 |
| MiR-223-3p might target gene SEPT6 and promoted the biological behavior of prostate cancer. | MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer.
Wei Y, Yang J, Yi L, Wang Y, Dong Z, Liu Z, Ou-yang S, Wu H, Zhong Z, Yin Z, Zhou K, Gao Y, Yan B, Wang Z., Free PMC Article | 10/3/2015 |
| Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis | Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis.
Traikov S, Stange C, Wassmer T, Paul-Gilloteaux P, Salamero J, Raposo G, Hoflack B., Free PMC Article | 07/25/2015 |
| The SEPT6 provides the directional guidance cues necessary for polarizing the epithelial microtubule network. | Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia.
Bowen JR, Hwang D, Bai X, Roy D, Spiliotis ET., Free PMC Article | 10/8/2011 |
| Data show that Septins of the SEPT6 group preferentially interacted with septins of the SEPT2 group, SEPT3 group and SEPT7 group. | A draft of the human septin interactome.
Nakahira M, Macedo JN, Seraphim TV, Cavalcante N, Souza TA, Damalio JC, Reyes LF, Assmann EM, Alborghetti MR, Garratt RC, Araujo AP, Zanchin NI, Barbosa JA, Kobarg J., Free PMC Article | 04/30/2011 |
| co-expression of SEPT12 altered the filamentous structure of SEPT6 in Hela cells | SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells.
Ding X, Yu W, Liu M, Shen S, Chen F, Wan B, Yu L. | 01/21/2010 |
| Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response. | Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
Kremer BE, Adang LA, Macara IG., Free PMC Article | 01/21/2010 |
| crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex | Structural insight into filament formation by mammalian septins.
Sirajuddin M, Farkasovsky M, Hauer F, Kühlmann D, Macara IG, Weyand M, Stark H, Wittinghofer A. | 01/21/2010 |
| These results indicate that the host proteins hnRNP A1 and septin 6 play important roles in the replication of HCV through RNA-protein and protein-protein interactions. | An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.
Kim CS, Seol SK, Song OK, Park JH, Jang SK., Free PMC Article | 01/21/2010 |
| MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia | MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.
Slater DJ, Hilgenfeld E, Rappaport EF, Shah N, Meek RG, Williams WR, Lovett BD, Osheroff N, Autar RS, Ried T, Felix CA. | 01/21/2010 |
| septin 2, 6, and 7 complexes make up polymerized filaments | Structural analysis of septin 2, 6, and 7 complexes.
Low C, Macara IG. | 01/21/2010 |
| Molecular analysis using rtPCR followed by sequencing confirmed the expression of an MLL-SEPT6 fusion transcript with a novel sequence. | MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia.
Kadkol SS, Bruno A, Oh S, Schmidt ML, Lindgren V. | 01/21/2010 |