| A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. | A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy.
Kuwabara Y, York AJ, Lin SC, Sargent MA, Grimes KM, Pirruccello JP, Molkentin JD., Free PMC Article | 05/4/2023 |
| Flightless I Homolog Reverses Enzalutamide Resistance through PD-L1-Mediated Immune Evasion in Prostate Cancer. | Flightless I Homolog Reverses Enzalutamide Resistance through PD-L1-Mediated Immune Evasion in Prostate Cancer.
Ruan H, Bao L, Tao Z, Chen K. | 02/26/2022 |
| FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon Receptor-Mediated Transcription in ARPE-19 Cells. | FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon Receptor-Mediated Transcription in ARPE-19 Cells.
Jeong KW., Free PMC Article | 02/19/2022 |
| Increased Expression of Flightless I in Cutaneous Squamous Cell Carcinoma Affects Wnt/beta-Catenin Signaling Pathway. | Increased Expression of Flightless I in Cutaneous Squamous Cell Carcinoma Affects Wnt/β-Catenin Signaling Pathway.
Yang GN, Strudwick XL, Bonder CS, Kopecki Z, Cowin AJ., Free PMC Article | 02/5/2022 |
| Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis. | Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis.
Nakajima K, Arora PD, Plaha A, McCulloch CA. | 09/11/2021 |
| Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca(2+) homeostasis. | Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca(2+) homeostasis.
Choi SS, Lee SK, Kim JK, Park HK, Lee E, Jang J, Lee YH, Khim KW, Hyun JM, Eom HJ, Lee S, Kang BH, Chae YC, Myung K, Myung SJ, Park CY, Choi JH., Free PMC Article | 08/14/2021 |
| Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model. | Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model.
Jackson JE, Kopecki Z, Anderson PJ, Cowin AJ., Free PMC Article | 05/22/2021 |
| Flightless I, a contributing factor to skin blistering in Kindler syndrome patients? | Flightless I, a contributing factor to skin blistering in Kindler syndrome patients?
Kopecki Z, Has C, Yang G, Bruckner-Tuderman L, Cowin A. | 04/3/2021 |
| Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds. | Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds.
Thomas HM, Ahangar P, Hofma BR, Strudwick XL, Fitridge R, Mills SJ, Cowin AJ., Free PMC Article | 02/20/2021 |
| the role of Flii in ulcerative colitis and mucosal damage | Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis.
Kopecki Z, Yang G, Treloar S, Mashtoub S, Howarth GS, Cummins AG, Cowin AJ., Free PMC Article | 08/12/2020 |
| this study shows that Flii alters the inflammatory response and autoantibody profile in an OVA-induced atopic dermatitis skin-like disease | Flightless I Alters the Inflammatory Response and Autoantibody Profile in an OVA-Induced Atopic Dermatitis Skin-Like Disease.
Kopecki Z, Stevens NE, Chong HT, Yang GN, Cowin AJ., Free PMC Article | 10/5/2019 |
| Flightless-I functions as a checkpoint protein for selective autophagy by interacting with p62 to block its recognition of LC3, leading to tumorigenesis in breast cancer. | Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression.
He JP, Hou PP, Chen QT, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ. | 09/21/2019 |
| Data reveal an unknown mechanism by which the transcription coactivator FLII regulates the GR-mediated repression of ERalpha target gene expression in MCF-7 cells. | Flightless-I mediates the repression of estrogen receptor α target gene expression by the glucocorticoid receptor in MCF-7 cells.
Yang L, Jeong KW. | 05/25/2019 |
| Low FLII expression is associated with lung carcinoma. | The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells.
Wang C, Chen K, Liao S, Gu W, Lian X, Zhang J, Gao X, Liu X, Wang T, He QY, Zhang G, Liu L. | 07/21/2018 |
| Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages. | F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2.
Burger D, Fickentscher C, de Moerloose P, Brandt KJ., Free PMC Article | 06/9/2018 |
| Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS/FLI activating response elements in vivo and reveal an unexpected role for the EWS portion of the EWS/FLI fusion in binding to sweet-spot GGAA-microsatellites. | Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth.
Johnson KM, Mahler NR, Saund RS, Theisen ER, Taslim C, Callender NW, Crow JC, Miller KR, Lessnick SL., Free PMC Article | 06/2/2018 |
| FLII is a component of the ChREBP transcriptional complex and negatively regulates ChREBP function in cancer cells. | Flightless I homolog negatively regulates ChREBP activity in cancer cells.
Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X. | 06/1/2018 |
| Demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients. | Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering.
Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ. | 06/1/2018 |
| FLII is associated with SENP3 and the MLL1/2 complex and FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus. | Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes.
Nayak A, Reck A, Morsczeck C, Müller S., Free PMC Article | 02/3/2018 |
| Flightless-I (Drosophila) homolog (FLII) activates TGFbeta1-mediated expression of COL1A2 gene. | Role of Flightless-I (Drosophila) homolog in the transcription activation of type I collagen gene mediated by transforming growth factor beta.
Lim MS, Jeong KW. | 09/23/2017 |
| Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion. | Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression.
Kopecki Z, Yang GN, Jackson JE, Melville EL, Calley MP, Murrell DF, Darby IA, O'Toole EA, Samuel MS, Cowin AJ., Free PMC Article | 03/4/2017 |
| FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies. | Flightless I Homolog Represses Prostate Cancer Progression through Targeting Androgen Receptor Signaling.
Wang T, Song W, Chen Y, Chen R, Liu Z, Wu L, Li M, Yang J, Wang L, Liu J, Ye Z, Wang C, Chen K. | 12/17/2016 |
| These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators. | Flightless I (Drosophila) homolog facilitates chromatin accessibility of the estrogen receptor α target genes in MCF-7 breast cancer cells.
Jeong KW. | 05/24/2014 |
| Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma. | Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion.
Lei N, Franken L, Ruzehaji N, Offenhäuser C, Cowin AJ, Murray RZ. | 04/27/2013 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |