| Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis. | Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis.
Wu J, Liu C, Yu G., Free PMC Article | 06/22/2023 |
| Biallelic alterations in PLXND1 cause common arterial trunk and other cardiac malformations in humans. | Biallelic alterations in PLXND1 cause common arterial trunk and other cardiac malformations in humans.
Guimier A, de Pontual L, Braddock SR, Torti E, Pérez-Jurado LA, Muñoz-Cabello P, Arumí M, Monaghan KG, Lee H, Wang LK, Pluym ID, Lynch SA, Stals K, Ellard S, Muller C, Houyel L, Cohen L, Lyonnet S, Bajolle F, Amiel J, Gordon CT. | 01/28/2023 |
| PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity in Colorectal Cancer. | PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity in Colorectal Cancer.
Hagihara K, Haraguchi N, Nishimura J, Yasueda A, Fujino S, Ogino T, Takahashi H, Miyoshi N, Uemura M, Matsuda C, Mizushima T, Yamamoto H, Mori M, Doki Y, Eguchi H. | 10/22/2022 |
| Association of PLXND1 with a novel subtype of anomalous pulmonary venous return. | Association of PLXND1 with a novel subtype of anomalous pulmonary venous return.
Zhou WZ, Zeng Z, Shen H, Chen W, Li T, Ma B, Sun Y, Yang F, Zhang Y, Li W, Han B, Liu X, Yuan M, Zhang G, Yang Y, Liu X, Pang KJ, Li SJ, Zhou Z. | 05/14/2022 |
| Identification of plexin D1 on circulating extracellular vesicles as a potential biomarker of polymyositis and dermatomyositis. | Identification of plexin D1 on circulating extracellular vesicles as a potential biomarker of polymyositis and dermatomyositis.
Uto K, Ueda K, Okano T, Akashi K, Takahashi S, Nakamachi Y, Imanishi T, Awano H, Morinobu A, Kawano S, Saegusa J. | 04/23/2022 |
| Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner. | Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner.
Carvalheiro T, Rafael-Vidal C, Malvar-Fernandez B, Lopes AP, Pego-Reigosa JM, Radstake TRDJ, Garcia S., Free PMC Article | 02/27/2021 |
| In the absence of neuropilins, plexin-A4 formed complexes with plexin-D1, and was required in addition to plexin-D1 to enable Sema3C-induced signal transduction. | Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins.
Smolkin T, Nir-Zvi I, Duvshani N, Mumblat Y, Kessler O, Neufeld G. | 12/7/2019 |
| The role of Plexin D1 in tumor development and progression is thereby garnering research interest for its potential as a biomarker and as a therapeutic target. | Divergent roles of Plexin D1 in cancer.
Vivekanadhan S, Mukhopadhyay D., Free PMC Article | 09/21/2019 |
| Anti-plexin D1 antibodies are a novel biomarker for immunotherapy-responsive neuropathic pain. | A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.
Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI. | 08/24/2019 |
| the receptor Plexin-D1 contains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes. | Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits.
Burk K, Mire E, Bellon A, Hocine M, Guillot J, Moraes F, Yoshida Y, Simons M, Chauvet S, Mann F., Free PMC Article | 11/10/2018 |
| SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM. | Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study.
Yan J, Su R, Ao D, Wang Y, Wang H, Yang H. | 10/27/2018 |
| Authors found that the PlexinD1 cleavage product binds to actin rods, pathological aggregate-like structures which had so far been described for age-related neurodegenerative diseases. Data suggest a novel disease mechanism for SMA involving formation of actin rods as a molecular sink for a cleaved PlexinD1 fragment leading to dysregulation of receptor signaling. | Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA).
Rademacher S, Verheijen BM, Hensel N, Peters M, Bora G, Brandes G, Vieira de Sá R, Heidrich N, Fischer S, Brinkmann H, van der Pol WL, Wirth B, Pasterkamp RJ, Claus P. | 03/10/2018 |
| Measuring electrical impedance allows real-time monitoring of changes in endothelial cell morphology and adhesion induced by SEMA3E via plexin D1 | An Electrical Impedance-Based Method for Quantitative Real-Time Analysis of Semaphorin-Elicited Endothelial Cell Collapse.
Camillo C, Gioelli N, Bussolino F, Serini G. | 02/17/2018 |
| Plexin D1 plays a role in collagen contraction in human lung fibroblasts. | Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor.
Peng HY, Gao W, Chong FR, Liu HY, Zhang JI. | 09/17/2016 |
| Findings suggest that Plexin-D1/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc) endothelium. | Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis.
Mazzotta C, Romano E, Bruni C, Manetti M, Lepri G, Bellando-Randone S, Blagojevic J, Ibba-Manneschi L, Matucci-Cerinic M, Guiducci S., Free PMC Article | 05/21/2016 |
| finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS patients suggests that de novo mutations in other genes might account for other MBS patients | De novo mutations in PLXND1 and REV3L cause Möbius syndrome.
Tomas-Roca L, Tsaalbi-Shtylik A, Jansen JG, Singh MK, Epstein JA, Altunoglu U, Verzijl H, Soria L, van Beusekom E, Roscioli T, Iqbal Z, Gilissen C, Hoischen A, de Brouwer APM, Erasmus C, Schubert D, Brunner H, Pérez Aytés A, Marin F, Aroca P, Kayserili H, Carta A, de Wind N, Padberg GW, van Bokhoven H., Free PMC Article | 03/26/2016 |
| The data indicate that Plexin-D1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type. | Positive regulation of neocortical synapse formation by the Plexin-D1 receptor.
Wang F, Eagleson KL, Levitt P., Free PMC Article | 03/5/2016 |
| Plxnd1 is a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans | Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.
Minchin JE, Dahlman I, Harvey CJ, Mejhert N, Singh MK, Epstein JA, Arner P, Torres-Vázquez J, Rawls JF., Free PMC Article | 07/4/2015 |
| The identification and characterization of SH3BP1 as a novel downstream effector of Sema3E-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior. | An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling.
Tata A, Stoppel DC, Hong S, Ben-Zvi A, Xie T, Gu C., Free PMC Article | 09/27/2014 |
| It is therefore suggested that SEMA3C signaling, propagated through the heterodimer receptor plexin-D1/neuropilin, is important for truncus arteriosus septation | Isolated truncus arteriosus associated with a mutation in the plexin-D1 gene.
Ta-Shma A, Pierri CL, Stepensky P, Shaag A, Zenvirt S, Elpeleg O, Rein AJ. | 07/5/2014 |
| A critical role of Sema3E/Plexin D1 interaction in tumor resistance to apoptosis. | Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers.
Luchino J, Hocine M, Amoureux MC, Gibert B, Bernet A, Royet A, Treilleux I, Lécine P, Borg JP, Mehlen P, Chauvet S, Mann F. | 01/11/2014 |
| Strong expression of plexD1 was detected in endothelial cells of cervical cancer samples, yet no expression was seen in endothelial cells of normal cervical tissues, which suggests a potential role of PlexD1 in cervical cancer-associated angiogenesis | Plexin D1: new potential biomarker for cervical cancer.
Shalaby MA, Hampson L, Oliver A, Hampson I. | 11/24/2012 |
| analysis of Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer | Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer.
Tseng CH, Murray KD, Jou MF, Hsu SM, Cheng HJ, Huang PH., Free PMC Article | 12/3/2011 |
| a novel phospholipid-regulated antiangiogenic signaling pathway whereby Sema3E activates Arf6 through Plexin-D1 and consequently controls integrin-mediated endothelial cell attachment to the extracellular matrix and migration. | Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.
Sakurai A, Jian X, Lee CJ, Manavski Y, Chavakis E, Donaldson J, Randazzo PA, Gutkind JS., Free PMC Article | 11/26/2011 |
| Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice | Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice.
Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A., Free PMC Article | 07/16/2011 |