| CLASP2 facilitates dynamic actin filament organization along the microtubule lattice. | CLASP2 facilitates dynamic actin filament organization along the microtubule lattice.
Rodgers NC, Lawrence EJ, Sawant AV, Efimova N, Gonzalez-Vasquez G, Hickman TT, Kaverina I, Zanic M., Free PMC Article | 02/25/2023 |
| CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner. | CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner.
Luo W, Demidov V, Shen Q, Girão H, Chakraborty M, Maiorov A, Ataullakhanov FI, Lin C, Maiato H, Grishchuk EL., Free PMC Article | 01/21/2023 |
| Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3beta and CK1delta regulates EB1-dependent MT dynamics in cell migration. | Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration.
Chia S, Leung T, Tan I. | 02/19/2022 |
| SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury. | SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.
Karki P, Ke Y, Zhang CO, Li Y, Tian Y, Son S, Yoshimura A, Kaibuchi K, Birukov KG, Birukova AA., Free PMC Article | 08/28/2021 |
| CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation. | CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation.
Aher A, Rai D, Schaedel L, Gaillard J, John K, Liu Q, Altelaar M, Blanchoin L, Thery M, Akhmanova A., Free PMC Article | 08/14/2021 |
| HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus. | HIV-1 Exploits CLASP2 To Induce Microtubule Stabilization and Facilitate Virus Trafficking to the Nucleus.
Mitra S, Shanmugapriya S, Santos da Silva E, Naghavi MH., Free PMC Article | 11/21/2020 |
| Significance of CLASP2 expression in prognosis for muscle-invasive bladder cancer patients: A propensity score-based analysis. | Significance of CLASP2 expression in prognosis for muscle-invasive bladder cancer patients: A propensity score-based analysis.
Chen L, Xiong W, Guo W, Su S, Qi L, Zhu B, Mo M, Jiang H, Li Y. | 09/19/2020 |
| CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments. | CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments.
Girão H, Okada N, Rodrigues TA, Silva AO, Figueiredo AC, Garcia Z, Moutinho-Santos T, Hayashi I, Azevedo JE, Macedo-Ribeiro S, Maiato H., Free PMC Article | 09/19/2020 |
| microtubules grown with CLASP2 display greater variability in growth rates. | Human CLASP2 specifically regulates microtubule catastrophe and rescue.
Lawrence EJ, Arpag G, Norris SR, Zanic M., Free PMC Article | 03/30/2019 |
| CLASP2 is involved in the epithelial-mesenchymal transition and progression of bladder urothelial cancer. Simultaneous urine-based detection of CLASP2 and E-cadherin mRNA can efficiently discriminate patients with or without 2-years progression after transurethral resection of the bladder tumor. | CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor.
Zhu B, Qi L, Liu S, Liu W, Ou Z, Chen M, Liu L, Zu X, Wang J, Li Y., Free PMC Article | 04/14/2018 |
| These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features. | Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes.
Shahbazi MN, Peña-Jimenez D, Antonucci F, Drosten M, Perez-Moreno M., Free PMC Article | 08/12/2017 |
| Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions. | Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.
Lim BC, Matsumoto S, Yamamoto H, Mizuno H, Kikuta J, Ishii M, Kikuchi A. | 08/5/2017 |
| this study shows that GSK3-mediated phosphorylation of CLASP2alpha largely abolishes CLASP2alpha-microtubule association in metaphase thus contributing to correct chromosome dynamics | GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics.
Pemble H, Kumar P, van Haren J, Wittmann T., Free PMC Article | 05/6/2017 |
| PAR3 and aPKC control the organization of the Golgi through CLASP2 phosphorylation. | PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity.
Matsui T, Watanabe T, Matsuzawa K, Kakeno M, Okumura N, Sugiyama I, Itoh N, Kaibuchi K., Free PMC Article | 01/2/2016 |
| GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of acetylcholine receptor cluster size through the regulated capture and release of microtubule plus-ends. | Acetylcholine receptor (AChR) clustering is regulated both by glycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level of CLIP-associated protein 2 (CLASP2) mediating the capture of microtubule plus-ends.
Basu S, Sladecek S, Pemble H, Wittmann T, Slotman JA, van Cappellen W, Brenner HR, Galjart N., Free PMC Article | 01/3/2015 |
| Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections. | CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.
Stehbens SJ, Paszek M, Pemble H, Ettinger A, Gierke S, Wittmann T., Free PMC Article | 08/9/2014 |
| Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 and CLASP2 is a potential pathogenic factor for a syndromic form of intellectual disability. | Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 and CLASP2 is a potential pathogenic factor for a syndromic form of intellectual disability: a co-morbidity model with additional copy number variations in a large family.
Marangi G, Orteschi D, Milano V, Mancano G, Zollino M. | 08/9/2014 |
| Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity. | Protein 4.1R binds to CLASP2 and regulates dynamics, organization and attachment of microtubules to the cell cortex.
Ruiz-Saenz A, van Haren J, Sayas CL, Rangel L, Demmers J, Millán J, Alonso MA, Galjart N, Correas I. | 07/19/2014 |
| The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP2, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM). | Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.
Nakaya Y, Sukowati EW, Sheng G., Free PMC Article | 11/23/2013 |
| Overexpression of human CLASP2 in mouse neurons caused the formation of multiple axons, enhanced dendritic branching, & Golgi condensation. These morphogenetic changes led to significant functional alterations in synaptic transmission. | Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function.
Beffert U, Dillon GM, Sullivan JM, Stuart CE, Gilbert JP, Kambouris JA, Ho A., Free PMC Article | 01/26/2013 |
| propose that Cdk1 and Plk1 mediate a fine CLASP2 "phospho-switch" that temporally regulates kinetochore-microtubule attachment stability | Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.
Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H., Free PMC Article | 01/12/2013 |
| Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1). | Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).
Kumar P, Chimenti MS, Pemble H, Schönichen A, Thompson O, Jacobson MP, Wittmann T., Free PMC Article | 07/28/2012 |
| Data show that CENP-E-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1/2-depleted cells. | CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.
Logarinho E, Maffini S, Barisic M, Marques A, Toso A, Meraldi P, Maiato H. | 05/12/2012 |
| Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP | Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.
Al-Bassam J, Chang F., Free PMC Article | 01/28/2012 |
| Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro. | FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.
Lanza DC, Meirelles GV, Alborghetti MR, Abrile CH, Lenz G, Kobarg J. | 10/23/2010 |