| Augustus Waller's foresight realized: SARM1 in peripheral neuropathies. | Augustus Waller's foresight realized: SARM1 in peripheral neuropathies.
Geisler S. | 08/13/2024 |
| Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons. | Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons.
Hinz FI, Villegas CLM, Roberts JT, Yao H, Gaddam S, Delwig A, Green SA, Fredrickson C, Adrian M, Asuncion RR, Cheung TK, Hayne M, Hackos DH, Rose CM, Richmond D, Hoogenraad CC., | 06/25/2024 |
| The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products. | The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products.
Garb J, Amitai G, Lu A, Ofir G, Brandis A, Mehlman T, Kranzusch PJ, Sorek R., Free PMC Article | 04/26/2024 |
| A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels. | A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels.
Icso JD, Thompson PR., Free PMC Article | 11/27/2023 |
| TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration. | TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration.
Czech VL, O'Connor LC, Philippon B, Norman E, Byrne AB., Free PMC Article | 05/8/2023 |
| The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity? | The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity?
Sarkar A, Kumari N, Mukherjee P. | 01/28/2023 |
| Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival. | Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival.
Ademi M, Yang X, Coleman MP, Gilley J., Free PMC Article | 08/27/2022 |
| Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer. | Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer.
Wu Y. | 07/16/2022 |
| TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line. | TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line.
Morale MG, Tamura RE, Cintra R, Araújo NM, Villa LL., Free PMC Article | 04/30/2022 |
| Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients. | Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients.
Bloom AJ, Mao X, Strickland A, Sasaki Y, Milbrandt J, DiAntonio A., Free PMC Article | 04/23/2022 |
| Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders. | Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders.
Gilley J, Jackson O, Pipis M, Estiar MA, Al-Chalabi A, Danzi MC, van Eijk KR, Goutman SA, Harms MB, Houlden H, Iacoangeli A, Kaye J, Lima L, Queen Square Genomics, Ravits J, Rouleau GA, Schüle R, Xu J, Züchner S, Cooper-Knock J, Gan-Or Z, Reilly MM, Coleman MP., Free PMC Article | 03/19/2022 |
| SARM1 can be a potential therapeutic target for spinal cord injury. | SARM1 can be a potential therapeutic target for spinal cord injury.
Lu Q, Botchway BOA, Zhang Y, Jin T, Liu X., Free PMC Article | 03/12/2022 |
| Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. | Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN.
Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA., Free PMC Article | 02/19/2022 |
| Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon. | Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon.
Sun Y, Wang Q, Wang Y, Ren W, Cao Y, Li J, Zhou X, Fu W, Yang J., Free PMC Article | 01/29/2022 |
| Expression of sterile-alpha and armadillo motif containing protein (SARM) in rheumatoid arthritis monocytes correlates with TLR2-induced IL-1beta and disease activity. | Expression of sterile-α and armadillo motif containing protein (SARM) in rheumatoid arthritis monocytes correlates with TLR2-induced IL-1β and disease activity.
Thwaites RS, Unterberger S, Chamberlain G, Gray H, Jordan K, Davies KA, Harrison NA, Sacre S., Free PMC Article | 01/1/2022 |
| Acidic pH irreversibly activates the signaling enzyme SARM1. | Acidic pH irreversibly activates the signaling enzyme SARM1.
Zhao YJ, He WM, Zhao ZY, Li WH, Wang QW, Hou YN, Tan Y, Zhang D. | 12/25/2021 |
| The NAD(+)-mediated self-inhibition mechanism of pro-neurodegenerative SARM1. | The NAD(+)-mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z. | 11/22/2021 |
| SARM1-mediated wallerian degeneration: A possible mechanism underlying organophosphorus-induced delayed neuropathy. | SARM1-mediated wallerian degeneration: A possible mechanism underlying organophosphorus-induced delayed neuropathy.
Song M, Kang K, Song F. | 10/9/2021 |
| SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration. | SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration.
Chen YH, Sasaki Y, DiAntonio A, Milbrandt J., Free PMC Article | 09/25/2021 |
| lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p. | lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p.
Yan K, Hou L, Liu T, Jiao W, Ma Q, Fang Z, Zhang S, Song D, Liu J, Gao X, Fan Y., Free PMC Article | 08/7/2021 |
| Multiple domain interfaces mediate SARM1 autoinhibition. | Multiple domain interfaces mediate SARM1 autoinhibition.
Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J., Free PMC Article | 06/12/2021 |
| Structural basis for SARM1 inhibition and activation under energetic stress. | Structural basis for SARM1 inhibition and activation under energetic stress.
Sporny M, Guez-Haddad J, Khazma T, Yaron A, Dessau M, Shkolnisky Y, Mim C, Isupov MN, Zalk R, Hons M, Opatowsky Y., Free PMC Article | 03/20/2021 |
| The SARM1 axon degeneration pathway: control of the NAD(+) metabolome regulates axon survival in health and disease. | The SARM1 axon degeneration pathway: control of the NAD(+) metabolome regulates axon survival in health and disease.
Figley MD, DiAntonio A., Free PMC Article | 11/21/2020 |
| Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. | Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.
Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A., Free PMC Article | 10/10/2020 |
| These results highlight the importance of oligomerization for SARM1 function and reveal critical epitopes for future targeted drug development. | Structural Evidence for an Octameric Ring Arrangement of SARM1.
Sporny M, Guez-Haddad J, Lebendiker M, Ulisse V, Volf A, Mim C, Isupov MN, Opatowsky Y. | 06/20/2020 |