| Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1[-] stem cell-like T cells over PD-1[+] T cells curbing tumor progression. | Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1(-) stem cell-like T cells over PD-1(+) T cells curbing tumor progression.
Del Rio ML, de Juan CY, Roncador G, Caleiras E, Álvarez-Esteban R, Pérez-Simón JA, Rodriguez-Barbosa JI., Free PMC Article | 08/10/2023 |
| Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development. | Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development.
Kugii Y, Kuroki Y, Hara Y, Goitsuka R, Nakano N. | 05/19/2023 |
| LIGHT Amplification by NF-kappaB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis. | LIGHT Amplification by NF-κB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis.
Lai D, Lv Z, Lu X, Shang P, Geng Y, Wang P., Free PMC Article | 01/28/2023 |
| The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota. | The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
Kou Y, Zheng X, Meng L, Liu M, Xu S, Jing Q, Zhang S, Wang H, Han J, Liu Z, Wei Y, Wang Y., Free PMC Article | 04/2/2022 |
| HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses. | HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses.
Burn Aschner C, Loh LN, Galen B, Delwel I, Jangra RK, Garforth SJ, Chandran K, Almo S, Jacobs WR Jr, Ware CF, Herold BC., Free PMC Article | 12/11/2021 |
| HVEM Promotes the Osteogenesis of allo-MSCs by Inhibiting the Secretion of IL-17 and IFN-gamma in Vgamma4T Cells. | HVEM Promotes the Osteogenesis of allo-MSCs by Inhibiting the Secretion of IL-17 and IFN-γ in Vγ4T Cells.
He L, Xiao J, Song L, Zhou R, Rong Z, He W, Dai F., Free PMC Article | 11/6/2021 |
| Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection. | Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection.
Park SJ, Riccio RE, Kopp SJ, Ifergan I, Miller SD, Longnecker R., Free PMC Article | 03/27/2021 |
| these results establish that HVEM restrains the T helper signals delivered to B cells to influence germinal center selection outcomes | The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
Mintz MA, Felce JH, Chou MY, Mayya V, Xu Y, Shui JW, An J, Li Z, Marson A, Okada T, Ware CF, Kronenberg M, Dustin ML, Cyster JG., Free PMC Article | 12/14/2019 |
| The HVEM ligand CD160 counterbalances stimulatory signals in highly activated and cytotoxic CD8(+) T effector cells. | HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.
Muscate F, Stetter N, Schramm C, Schulze Zur Wiesch J, Bosurgi L, Jacobs T., Free PMC Article | 10/5/2019 |
| Mice with a conditional deletion of the LIGHT receptor HVEM (herpesvirus entry mediator) in keratinocytes phenocopied LIGHT-deficient mice in exhibiting reduced epidermal thickening and dermal collagen deposition in a model of atopic dermatitis driven by house dust mite allergen. | LIGHT-HVEM signaling in keratinocytes controls development of dermatitis.
Herro R, Shui JW, Zahner S, Sidler D, Kawakami Y, Kawakami T, Tamada K, Kronenberg M, Croft M., Free PMC Article | 04/13/2019 |
| these data indicate that HVEM/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies following skin transplantation | T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway.
Rodriguez-Barbosa JI, Fernandez-Renedo C, Moral AMB, Bühler L, Del Rio ML., Free PMC Article | 03/10/2018 |
| LIGHT promote myeloid differentiation of Hematopoietic stem/progenitor cells via LIGHT receptor signaling. | Hematopoietic stem/progenitor cell differentiation towards myeloid lineage is modulated by LIGHT/LIGHT receptor signaling.
Chen W, Lv X, Liu C, Chen R, Liu J, Dai H, Zou GM. | 11/25/2017 |
| HVEM represents a critical signal for memory precursor effector cells and development of protective mucosal CD8 T cell memory | HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity.
Desai P, Abboud G, Stanfield J, Thomas PG, Song J, Ware CF, Croft M, Salek-Ardakani S., Free PMC Article | 11/4/2017 |
| Dendritic cells require BTLA and HVEM to actively adjust tolerizing T cell responses under steady-state conditions. | Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.
Jones A, Bourque J, Kuehm L, Opejin A, Teague RM, Gross C, Hawiger D., Free PMC Article | 09/16/2017 |
| we identified herpes virus entry mediator as a functional receptor that mediates SALM5's suppressive function. Our findings reveal a molecular link between the neuronal system and the immune system, and provide potential therapeutic targets for the control of CNS diseases. | Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM.
Zhu Y, Yao S, Augustine MM, Xu H, Wang J, Sun J, Broadwater M, Ruff W, Luo L, Zhu G, Tamada K, Chen L., Free PMC Article | 12/24/2016 |
| results have revealed a novel role of HVEM on the regulation of IFN-I and immunopathology during Listeria infection. | Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon.
Lv M, Wu W, Zhang Y, Zhu M., Free PMC Article | 08/6/2016 |
| our studies revealed a novel function of the HVEM cosignaling molecule and its ligands in EAU pathogenesis through the induction of Th1- and Th17-type T cell responses | Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of Th1- and Th17-Type T Cell Responses.
Sakoda Y, Nagai T, Murata S, Mizuno Y, Kurosawa H, Shoda H, Morishige N, Yanai R, Sonoda KH, Tamada K. | 08/6/2016 |
| Together, these data indicate that HVEM contributes to ocular pathogenesis independently of entry and point to an immunomodulatory role for this protein specifically on radiation-resistant cells. | Herpesvirus entry mediator on radiation-resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry-independent manner.
Edwards RG, Kopp SJ, Karaba AH, Wilcox DR, Longnecker R., Free PMC Article | 07/30/2016 |
| results demonstrate a role for both nectin-1 and HVEM as receptors and suggest a further receptor which appears much less efficient. | Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors for Herpes Simplex Virus 1 on Primary Murine Dermal Fibroblasts.
Petermann P, Rahn E, Thier K, Hsu MJ, Rixon FJ, Kopp SJ, Knebel-Mörsdorf D., Free PMC Article | 11/7/2015 |
| Authors show that CD4(+) FoxP3(+) Tregs up- regulate HVEM (herpes virus entry mediator), which is a binding site for major viral glycoprotein gD, following herpes simplex virus 1 infection. | Herpes virus entry mediator (HVEM) modulates proliferation and activation of regulatory T cells following HSV-1 infection.
Sharma S, Rajasagi NK, Veiga-Parga T, Rouse BT., Free PMC Article | 05/16/2015 |
| results support a model whereby BTLA on innate leukocytes is triggered by HVEM and delivers negative signals into BTLA(+) cells, thereby interfering with the protective immune response to this intestinal parasite. | Cutting Edge: the BTLA-HVEM regulatory pathway interferes with protective immunity to intestinal Helminth infection.
Breloer M, Hartmann W, Blankenhaus B, Eschbach ML, Pfeffer K, Jacobs T. | 04/25/2015 |
| In summary, herpes simplex virus 1 entry into epidermis was shown to strongly depend on the presence of nectin-1, but the restricted presence of HVEM can potentially replace nectin-1 as a receptor. | Entry mechanisms of herpes simplex virus 1 into murine epidermis: involvement of nectin-1 and herpesvirus entry mediator as cellular receptors.
Petermann P, Thier K, Rahn E, Rixon FJ, Bloch W, Özcelik S, Krummenacher C, Barron MJ, Dixon MJ, Scheu S, Pfeffer K, Knebel-Mörsdorf D., Free PMC Article | 03/21/2015 |
| One mechanism by which the herpes simplex virus 1 latency-associated transcript enhances latency and reactivation appears to be by upregulating HVEM expression. | Interactions between herpesvirus entry mediator (TNFRSF14) and latency-associated transcript during herpes simplex virus 1 latency.
Allen SJ, Rhode-Kurnow A, Mott KR, Jiang X, Carpenter D, Rodriguez-Barbosa JI, Jones C, Wechsler SL, Ware CF, Ghiasi H., Free PMC Article | 04/12/2014 |
| Data indicate taht tumor necrosis factor receptor superfamily member 14 (TNFRSF14)participated in ovariectomy (OVX)-induced adipose tissue (AT) inflammation via upregulation of CD11c, resulting in metabolic perturbation. | TNFRSF14 deficiency protects against ovariectomy-induced adipose tissue inflammation.
Choi EK, Kim WK, Sul OJ, Park YK, Kim ES, Suh JH, Yu R, Choi HS. | 02/1/2014 |
| These results suggest that differences in nectin-1 and HVEM receptor expression between adults and newborns may partially explain differences in susceptibility to herpes simplex 2. | Pathogenesis of neonatal herpes simplex 2 disease in a mouse model is dependent on entry receptor expression and route of inoculation.
Kopp SJ, Karaba AH, Cohen LK, Banisadr G, Miller RJ, Muller WJ., Free PMC Article | 03/2/2013 |