| ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility. | ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
Zhu Q, Taylor JM., | 08/20/2024 |
| GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. | GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
Zhu Q, Combs ME, Liu J, Bai X, Wang WB, Herring LE, Liu J, Locasale JW, Bowles DE, Gross RT, Pla MM, Mack CP, Taylor JM., Free PMC Article | 12/20/2023 |
| CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway. | CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.
Xu G, Zhao L, Hua Q, Wang L, Liu H, Lin Z, Jin M, Wang J, Zhou P, Yang K, Wu G, Yu D, Zhang D, Zhang T., Free PMC Article | 03/6/2023 |
| Missense Variants in <i>GFRA1</i> and <i>NPNT</i> Are Associated with Congenital Anomalies of the Kidney and Urinary Tract. | Missense Variants in GFRA1 and NPNT Are Associated with Congenital Anomalies of the Kidney and Urinary Tract.
Al-Hamed MH, Sayer JA, Alsahan N, Edwards N, Ali W, Tulbah M, Imtiaz F., Free PMC Article | 11/12/2022 |
| Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease. | Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease.
Wang K, Lu Y, Morrow DF, Xiao D, Xu C, Alzheimer’s Disease Neuroimaging Initiative. | 05/14/2022 |
| The role of GTPase-activating protein ARHGAP26 in human cancers. | The role of GTPase-activating protein ARHGAP26 in human cancers.
Zhang L, Zhou A, Zhu S, Min L, Liu S, Li P, Zhang S., Free PMC Article | 03/19/2022 |
| Data indicate that hypoxia-induced Rho GTPase activating protein 26 (ARHGAP26) deficiency inhibits ductus arteriosus smooth muscle cells (DASMCs) proliferation and migration through activating the RhoA-ROCK-PTEN pathway. | Hypoxia-induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA-ROCK-PTEN pathway.
Li M, Ye L, Ye X, Wang S, Zhang H, Liu J, Hong H. | 07/25/2020 |
| ARHGAP26 upregulation in SKOV3 cells significantly inhibited SMURF1 upregulation-induced cell migration and invasion. Overall, SMURF1-mediated ubiquitination of ARHGAP26 may promote invasion and migration of ovarian cancer cells via the beta-catenin pathway. | SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.
Chen X, Chen S, Li Y, Gao Y, Huang S, Li H, Zhu Y., Free PMC Article | 06/13/2020 |
| High ARHGAP26 expression is associated with adenomyosis. | RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
Jiang C, Gong W, Chen R, Ke H, Qu X, Yang W, Cheng Z., Free PMC Article | 07/13/2019 |
| This study showed that the circARHGAP26 is overexpressed and its downregulation inhibits cell proliferation and promotes cells apoptosis in GC cells. | Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells.
Wangxia LV, Fang Y, Liu Y, Zhao Y, Shi Z, Zhong H., Free PMC Article | 04/27/2019 |
| GRAF1 plays a role in the maintenance of normal epithelial phenotype and its depletion leads to an epithelial-mesenchymal transition-like process that might be involved in neoplastic transformation. | Involvement of Rho GAP GRAF1 in maintenance of epithelial phenotype.
Regev M, Sabanay H, Kartvelishvily E, Kam Z, Bershadsky AD., Free PMC Article | 05/19/2018 |
| We conclude that a transient interaction between Cdc42 and GRAF1 drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism. | Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1.
Francis MK, Holst MR, Vidal-Quadras M, Henriksson S, Santarella-Mellwig R, Sandblad L, Lundmark R., Free PMC Article | 10/1/2016 |
| GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia. | High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia.
Aly RM, Ghazy HF. | 06/20/2015 |
| ADAR1 regulates the expression of ARHGAP26 through A-to-I RNA editing by disrupting the binding of miR-30b-3p and miR-573 within the 3' UTR of ARHGAP26. | ADAR1 regulates ARHGAP26 gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding.
Wang Q, Hui H, Guo Z, Zhang W, Hu Y, He T, Tai Y, Peng P, Wang L., Free PMC Article | 12/21/2013 |
| proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes | The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading.
Doherty GJ, Åhlund MK, Howes MT, Morén B, Parton RG, McMahon HT, Lundmark R., Free PMC Article | 05/19/2012 |
| Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML. | Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia.
Qian J, Qian Z, Lin J, Yao DM, Chen Q, Li Y, Ji RB, Yang J, Xiao GF, Wang YL. | 12/10/2011 |
| a GTPase-activating protein that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation | Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating protein (Rho-GAP), GRAF1.
Doherty JT, Lenhart KC, Cameron MV, Mack CP, Conlon FL, Taylor JM., Free PMC Article | 09/17/2011 |
| Decreased level of GRAF transcript is associated with acute myeloid leukemia, myelodysplastic syndrome and chronic myeloid leukemia. | GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies.
Qian Z, Qian J, Lin J, Yao DM, Chen Q, Ji RB, Li Y, Xiao GF, Li JY., Free PMC Article | 10/30/2010 |
| The GRAF gene was down-regulated in AML, which might play a role in the leukemogenesis. | [Quantification of GRAF gene expression in patients with acute myeloid leukemia using EvaGreen real time quantitative PCR].
Qian Z, Lin J, Qian J, Yao DM, Wang YL, Han LX, Zhu ZH, Xiao GF. | 09/20/2010 |
| The analysis of the expression pattern of the GRAF1/OPHN-1-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform. | Decreased expression of GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome.
Barresi V, Ragusa A, Fichera M, Musso N, Castiglia L, Rappazzo G, Travali S, Mattina T, Romano C, Cocchi G, Condorelli DF., Free PMC Article | 09/13/2010 |
| abnormal GRAF methylation might be an adverse prognostic event in MDS | Aberrant methylation of GTPase regulator associated with the focal adhesion kinase (GRAF) promoter is an adverse prognostic factor in myelodysplastic syndrome.
Qian J, Qian Z, Lin J, Yao DM, Zhu ZH, Chen Q, Xiao GF, Li JY. | 08/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Graf residues important for the structural integrity are critical for binding RhoA and for the catalytic activity of GAP, but GTPase selectivity appears to be modulated by a more subtle interplay involving residues on the periphery of the main interface. | Dissecting the thermodynamics of GAP-RhoA interactions.
Jelen F, Lachowicz P, Apostoluk W, Mateja A, Derewenda ZS, Otlewski J., Free PMC Article | 01/21/2010 |
| GRAF is a negative regulator of RhoA in vivo, it acts as a GTP-ase activating protein (GAP) for RhoA and may be a downstream effector of RhoA in certain cell types. | Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.
Taylor JM, Macklem MM, Parsons JT. | 03/5/2001 |