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    PEG10 paternally expressed 10 [ Homo sapiens (human) ]

    Gene ID: 23089, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma.

    GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma.
    Qin L, Wang J, Cheng F, Cheng J, Zhang H, Zheng H, Liu Y, Liang Z, Wang B, Li C, Wang H, Ju Y, Tian H, Meng S., Free PMC Article

    12/16/2023
    Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia.

    Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia.
    Baird L, Cannon P, Kandel M, Nguyen TV, Nguyen A, Wong G, Murphy C, Brownfoot FC, Kadife E, Hannan NJ, Tong S, Bartho LA, Kaitu'u-Lino TJ., Free PMC Article

    07/25/2023
    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS.

    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS.
    Black HH, Hanson JL, Roberts JE, Leslie SN, Campodonico W, Ebmeier CC, Holling GA, Tay JW, Matthews AM, Ung E, Lau CI, Whiteley AM., Free PMC Article

    04/7/2023
    LncRNA NALT1 promotes colorectal cancer progression via targeting PEG10 by sponging microRNA-574-5p.

    LncRNA NALT1 promotes colorectal cancer progression via targeting PEG10 by sponging microRNA-574-5p.
    Ye M, Zhao L, Zhang L, Wu S, Li Z, Qin Y, Lin F, Pan L., Free PMC Article

    11/26/2022
    Folate deficiency disturbs PEG10 methylation modifications in human spina bifida.

    Folate deficiency disturbs PEG10 methylation modifications in human spina bifida.
    Lu X, Yang S, Jie M, Wang S, Sun C, Wu L, Chang S, Pei P, Wang S, Zhang T, Wang L.

    10/29/2022
    Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity.

    Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity.
    Zhang B, Liu ZY, Wu R, Zhang CM, Cao K, Shan WG, Liu Z, Ji M, Tian ZL, Sethi G, Shi HL, Wang RH., Free PMC Article

    08/6/2022
    CRISPR activation screen identifies TGFbeta-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma.

    CRISPR activation screen identifies TGFβ-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma.
    Saratov V, Ngo QA, Pedot G, Sidorov S, Wachtel M, Niggli FK, Schäfer BW., Free PMC Article

    07/2/2022
    PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma.

    PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma.
    Liu F, Gao Y, Xu B, Xiong S, Yi S, Sun J, Chen Z, Liu X, Li Y, Lin Y, Wen Y, Qin Y, Yang S, Li H, Tejasvi T, Tsoi L, Tu P, Ren X, Wang Y., Free PMC Article

    03/12/2022
    Circ_0075804 promotes the malignant behaviors of retinoblastoma cells by binding to miR-138-5p to induce PEG10 expression.

    Circ_0075804 promotes the malignant behaviors of retinoblastoma cells by binding to miR-138-5p to induce PEG10 expression.
    Zhang Y, Dou X, Kong Q, Li Y, Zhou X.

    03/5/2022
    Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.

    Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.
    Pandya NJ, Wang C, Costa V, Lopatta P, Meier S, Zampeta FI, Punt AM, Mientjes E, Grossen P, Distler T, Tzouros M, Martí Y, Banfai B, Patsch C, Rasmussen S, Hoener M, Berrera M, Kremer T, Dunkley T, Ebeling M, Distel B, Elgersma Y, Jagasia R., Free PMC Article

    03/5/2022
    Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins.

    Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins.
    Zurowska K, Alam A, Ganser-Pornillos BK, Pornillos O., Free PMC Article

    02/12/2022
    Expression and DNA Methylation Status of the Imprinted Genes PEG10 and L3MBTL1 in the Umbilical Cord Blood and Placenta of the Offspring of Assisted Reproductive Technology.

    Expression and DNA Methylation Status of the Imprinted Genes PEG10 and L3MBTL1 in the Umbilical Cord Blood and Placenta of the Offspring of Assisted Reproductive Technology.
    Wang YX, Yue LF, Zhang JW, Xiong YW, Hu JJ, Wang LL, Li Z, Liu Y, Yang L, Sun LJ.

    12/4/2021
    Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery.

    Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery.
    Segel M, Lash B, Song J, Ladha A, Liu CC, Jin X, Mekhedov SL, Macrae RK, Koonin EV, Zhang F., Free PMC Article

    08/28/2021
    Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer.

    Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer.
    Kawai Y, Imada K, Akamatsu S, Zhang F, Seiler R, Hayashi T, Leong J, Beraldi E, Saxena N, Kretschmer A, Oo HZ, Contreras-Sanz A, Matsuyama H, Lin D, Fazli L, Collins CC, Wyatt AW, Black PC, Gleave ME.

    08/7/2021
    IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression.

    IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression.
    Zhang L, Wan Y, Zhang Z, Jiang Y, Gu Z, Ma X, Nie S, Yang J, Lang J, Cheng W, Zhu L., Free PMC Article

    07/24/2021
    Differential Expression of PEG10 Contributes to Aggressive Disease in Early Versus Late-Onset Colorectal Cancer.

    Differential Expression of PEG10 Contributes to Aggressive Disease in Early Versus Late-Onset Colorectal Cancer.
    Watson KM, Gardner IH, Byrne RM, Ruhl RR, Lanciault CP, Dewey EN, Anand S, Tsikitis VL., Free PMC Article

    02/2/2021
    Functional Study of the Retrotransposon-Derived Human PEG10 Protease.

    Functional Study of the Retrotransposon-Derived Human PEG10 Protease.
    Golda M, Mótyán JA, Mahdi M, Tőzsér J., Free PMC Article

    01/9/2021
    Declination of long noncoding RNA paternally expressed gene 10 inhibits A375 cells proliferation, migration, and invasion via mediating microRNA-33a.

    Declination of long noncoding RNA paternally expressed gene 10 inhibits A375 cells proliferation, migration, and invasion via mediating microRNA-33a.
    Fu Y, Bi Y, Wang F, Chen X, Liu H.

    11/21/2020
    PEG10 is expressed by prostate cancer with constitutively active AR-splice variants.

    PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer.
    Shapovalova M, Lee JK, Li Y, Vander Griend DJ, Coleman IM, Nelson PS, Dehm SM, LeBeau AM., Free PMC Article

    05/30/2020
    Results suggest that tumour susceptibility gene 101 (TSG101) is up-regulated in hepatocellular carcinoma (HCC) patients, which may accelerate the proliferation, migration and invasion of HCC cells through paternally expressed 10 protein (PEG10).

    TSG101 promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by regulating the PEG10.
    Liu Z, Tian Z, Cao K, Zhang B, Wen Q, Zhou X, Yang W, Wang T, Shi H, Wang R., Free PMC Article

    04/11/2020
    Study provided the first evidence that expression level of lncRNA PEG10 was significantly correlated with the advanced clinicopathological features and poor outcome in patients with gliomas. LncRNA PEG10 can be identified as an oncogenic biomarker for the relapse and clinical outcome in glioma patients.

    Prediction of relapse and prognosis by expression levels of long noncoding RNA PEG10 in glioma patients.
    Xiao H, Ding N, Liao H, Yao Z, Cheng X, Zhang J, Zhao M., Free PMC Article

    11/23/2019
    PEG10 knockdown inhibited cell viability, migration and invasion, induced cell apoptosis through miR-506 upregulation, as well as inactivation of Raf/MEK/ERK and JAK1/STAT3 signal pathways in human glioma cell line U251 cells

    Knockdown long non-coding RNA PEG10 inhibits proliferation, migration and invasion of glioma cell line U251 by regulating miR-506.
    Liang J, Liu N, Xin H.

    09/14/2019
    USP11 depletion suppresses cell proliferation and wound healing in lung epithelial cells, and these effects are reversed by E2F1 and PEG10 overexpression.

    Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.
    Wang D, Zhao J, Li S, Wei J, Nan L, Mallampalli RK, Weathington NM, Ma H, Zhao Y., Free PMC Article

    09/14/2019
    PEG10 repressed TGF-beta and BMP signaling in chondrosarcoma cells. PEG10 knockdown increased the level of phosphorylated SMAD3 and SMAD1/5/9.

    TGF-β signalling and PEG10 are mutually exclusive and inhibitory in chondrosarcoma cells.
    Shinohara N, Maeda S, Yahiro Y, Sakuma D, Matsuyama K, Imamura K, Kawamura I, Setoguchi T, Ishidou Y, Nagano S, Komiya S., Free PMC Article

    07/6/2019
    PEG10 might be a molecular target for suppressing the aggressive phenotypes of chondrosarcoma cells.

    PEG10 counteracts signaling pathways of TGF-β and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells.
    Yahiro Y, Maeda S, Shinohara N, Jokoji G, Sakuma D, Setoguchi T, Ishidou Y, Nagano S, Komiya S, Taniguchi N.

    06/22/2019
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