| The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis. | The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.
Liu Y, Wang S, Wei S, Qiu X, Mei Y, Yan L., Free PMC Article | 02/1/2024 |
| KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations. | KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.
Wang K, Gong Z, Chen Y, Zhang M, Wang S, Yao S, Liu Z, Huang Z, Fei B., Free PMC Article | 11/1/2023 |
| The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells. | The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.
Staehle AM, Peeken JC, Vladimirov G, Hoeness ME, Bojtine Kovacs S, Karantzelis N, Gruender A, Koellerer C, Jutzi JS, Pahl HL, Staehle HF., Free PMC Article | 04/12/2023 |
| Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas. | Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
Lopez C, Schleussner N, Bernhart SH, Kleinheinz K, Sungalee S, Sczakiel HL, Kretzmer H, Toprak UH, Glaser S, Wagener R, Ammerpohl O, Bens S, Giefing M, Sanchez JCG, Apic G, Hubschmann D, Janz M, Kreuz M, Mottok A, Muller JM, Seufert J, Hoffmann S, Korbel JO, Russell RB, Schule R, Trumper L, Klapper W, Radlwimmer B, Lichter P, Kuppers R, Schlesner M, Mathas S, Siebert R., Free PMC Article | 02/11/2023 |
| KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle. | KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle.
Close K, Fitzgibbon J., Free PMC Article | 02/11/2023 |
| Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury. | Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.
Pan HC, Chen YH, Fang WC, Wu VC, Sun CY., Free PMC Article | 09/3/2022 |
| Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype. | Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.
Katainen R, Donner I, Räisänen M, Berta D, Kuosmanen A, Kaasinen E, Hietala M, Aaltonen LA., Free PMC Article | 07/2/2022 |
| Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway. | Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway.
Li Q, Qu B, Shen H, Deng H, Sun L. | 04/30/2022 |
| JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer. | JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.
Zhang J, Wang M, Wang J, Wang W., Free PMC Article | 04/16/2022 |
| Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism. | Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism.
Lin CY, Wang BJ, Fu YK, Huo C, Wang YP, Chen BC, Liu WY, Tseng JC, Jiang SS, Sie ZL, Tsai KK, Yuh CH, Wang WC, Kung HJ, Chuu CP., Free PMC Article | 04/9/2022 |
| Disruption of KDM4C-ALDH1A3 feed-forward loop inhibits stemness, tumorigenesis and chemoresistance of gastric cancer stem cells. | Disruption of KDM4C-ALDH1A3 feed-forward loop inhibits stemness, tumorigenesis and chemoresistance of gastric cancer stem cells.
Lang T, Xu J, Zhou L, Zhang Z, Ma X, Gu J, Liu J, Li Y, Ding D, Qiu J., Free PMC Article | 03/26/2022 |
| USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-beta2 transcription. | USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription.
Jie X, Fong WP, Zhou R, Zhao Y, Zhao Y, Meng R, Zhang S, Dong X, Zhang T, Yang K, Wu G, Xu S., Free PMC Article | 03/5/2022 |
| UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications. | UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications.
Gao Y, Liu Y, Liu Y, Peng Y, Yuan B, Fu Y, Qi X, Zhu Q, Cao T, Zhang S, Yin L, Li X. | 01/8/2022 |
| JMJD2C triggers the growth of multiple myeloma cells via activation of betacatenin. | JMJD2C triggers the growth of multiple myeloma cells via activation of β‑catenin.
Lv M, Liu Q., Free PMC Article | 10/16/2021 |
| Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc. | Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.
Lee DH, Kim GW, Yoo J, Lee SW, Jeon YH, Kim SY, Kang HG, Kim DH, Chun KH, Choi J, Kwon SH., Free PMC Article | 10/2/2021 |
| GASC1 promotes hepatocellular carcinoma progression by inhibiting the degradation of ROCK2. | GASC1 promotes hepatocellular carcinoma progression by inhibiting the degradation of ROCK2.
Shao N, Cheng J, Huang H, Gong X, Lu Y, Idris M, Peng X, Ong BX, Zhang Q, Xu F, Liu C., Free PMC Article | 09/18/2021 |
| Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder. | Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder.
Kato H, Kushima I, Mori D, Yoshimi A, Aleksic B, Nawa Y, Toyama M, Furuta S, Yu Y, Ishizuka K, Kimura H, Arioka Y, Tsujimura K, Morikawa M, Okada T, Inada T, Nakatochi M, Shinjo K, Kondo Y, Kaibuchi K, Funabiki Y, Kimura R, Suzuki T, Yamakawa K, Ikeda M, Iwata N, Takahashi T, Suzuki M, Okahisa Y, Takaki M, Egawa J, Someya T, Ozaki N., Free PMC Article | 08/7/2021 |
| microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1alpha/HES1 signaling axis. | microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis.
Yang D, Xu T, Fan L, Liu K, Li G., Free PMC Article | 06/12/2021 |
| Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. | Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer.
Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH., Free PMC Article | 05/22/2021 |
| GASC1 promotes glioma progression by enhancing NOTCH1 signaling. | GASC1 promotes glioma progression by enhancing NOTCH1 signaling.
Xiao Z, Yang X, Liu Z, Shao Z, Song C, Zhang K, Wang X, Li Z., Free PMC Article | 05/15/2021 |
| Wnt-Induced Stabilization of KDM4C Is Required for Wnt/beta-Catenin Target Gene Expression and Glioblastoma Tumorigenesis. | Wnt-Induced Stabilization of KDM4C Is Required for Wnt/β-Catenin Target Gene Expression and Glioblastoma Tumorigenesis.
Chen Y, Fang R, Yue C, Chang G, Li P, Guo Q, Wang J, Zhou A, Zhang S, Fuller GN, Shi X, Huang S., Free PMC Article | 10/3/2020 |
| Data found that JMJD2C was overexpressed in colorectal cancer (CRC) tumor and metastatic foci, and CRC patients with lower JMJD2C expression had better prognosis. JMJD2C could enhance the metastatic abilities of CRC cells in vitro and in vivo by regulating the histone methylation level of MALAT1 promoter, thereby up-regulating the expression of MALAT1 and enhancing the activity of beta-catenin signaling pathway. | JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway.
Wu X, Li R, Song Q, Zhang C, Jia R, Han Z, Zhou L, Sui H, Liu X, Zhu H, Yang L, Wang Y, Ji Q, Li Q., Free PMC Article | 03/28/2020 |
| data indicate that circKDM4C might have considerable potential as a prognostic biomarker in breast cancer, and support the notion that therapeutic targeting of circKDM4C/miR-548p/PBLD axis may be a promising treatment approach for breast cancer patients | circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer.
Liang Y, Song X, Li Y, Su P, Han D, Ma T, Guo R, Chen B, Zhao W, Sang Y, Zhang N, Li X, Zhang H, Liu Y, Duan Y, Wang L, Yang Q. | 02/29/2020 |
| we have identified KDM4C as a new risk gene shared between systemic vasculitides, consistent with the increasing evidences of the crucial role that the epigenetic mechanisms have in the development of complex immune-mediated conditions. | Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Ortiz-Fernández L, Carmona FD, López-Mejías R, González-Escribano MF, Lyons PA, Morgan AW, Sawalha AH, Merkel PA, Smith KGC, González-Gay MA, Martín J, Spanish GCA Study Group, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group., Free PMC Article | 01/26/2019 |
| LSD1 and JMJD2C disable oncogenic Ras- or Braf-induced senescence by enabling the expression of E2F target genes | Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S., Free PMC Article | 12/22/2018 |