| PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1. | PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1.
Nakata Y, Nagasawa S, Sera Y, Yamasaki N, Kanai A, Kobatake K, Ueda T, Koizumi M, Manabe I, Kaminuma O, Honda H., Free PMC Article | 08/16/2024 |
| Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer. | Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.
Harvey-Jones E, Raghunandan M, Robbez-Masson L, Magraner-Pardo L, Alaguthurai T, Yablonovitch A, Yen J, Xiao H, Brough R, Frankum J, Song F, Yeung J, Savy T, Gulati A, Alexander J, Kemp H, Starling C, Konde A, Marlow R, Cheang M, Proszek P, Hubank M, Cai M, Trendell J, Lu R, Liccardo R, Ravindran N, Llop-Guevara A, Rodriguez O, Balmana J, Lukashchuk N, Dorschner M, Drusbosky L, Roxanis I, Serra V, Haider S, Pettitt SJ, Lord CJ, Tutt ANJ. | 04/15/2024 |
| Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility. | Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
Gupta N, Sarkar S, Mehta P, Sankhwar SN, Rajender S. | 09/17/2022 |
| PTIP governs NAD(+) metabolism by regulating CD38 expression to drive macrophage inflammation. | PTIP governs NAD(+) metabolism by regulating CD38 expression to drive macrophage inflammation.
Wang Q, Hu J, Han G, Wang P, Li S, Chang J, Gao K, Yin R, Li Y, Zhang T, Chai J, Gao Z, Zhang T, Cheng Y, Guo C, Wang J, Liu W, Cui M, Xu Y, Hou J, Zhu QF, Feng YQ, Zhang H. | 04/9/2022 |
| PAXIP1 and 53BP1 protein levels followed gene expression results, i.e., are intrinsically correlated, and also reduced in more advanced breast cancer tumors. | DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis.
De Gregoriis G, Ramos JA, Fernandes PV, Vignal GM, Brianese RC, Carraro DM, Monteiro AN, Struchiner CJ, Suarez-Kurtz G, Vianna-Jorge R, de Carvalho MA., Free PMC Article | 04/28/2018 |
| PAXIP1 is involved in sensitizing lung cancer cells to the WEE1 inhibitor AZD1775 in combination with platinum-based treatment. | PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer.
Jhuraney A, Woods NT, Wright G, Rix L, Kinose F, Kroeger JL, Remily-Wood E, Cress WD, Koomen JM, Brantley SG, Gray JE, Haura EB, Rix U, Monteiro AN., Free PMC Article | 07/1/2017 |
| PTIP promotes double-strand break repair through a direct role in homologous recombination. | PTIP promotes DNA double-strand break repair through homologous recombination.
Wang X, Takenaka K, Takeda S. | 07/4/2015 |
| PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation. | The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.
Abraham S, Paknikar R, Bhumbra S, Luan D, Garg R, Dressler GR, Patel SR., Free PMC Article | 05/30/2015 |
| uncovered a nuclease, Artemis, as a PTIP-binding protein | PTIP associates with Artemis to dictate DNA repair pathway choice.
Wang J, Aroumougame A, Lobrich M, Li Y, Chen D, Chen J, Gong Z., Free PMC Article | 02/14/2015 |
| PITX2 and PTIP co-occupy the promoter of the PITX2's transcriptional target. | PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex.
Liu Y, Huang Y, Fan J, Zhu GZ., Free PMC Article | 04/26/2014 |
| Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability. | A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.
Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR., Free PMC Article | 03/16/2013 |
| a new clue to identify the role of PTIP in DNA damage pathway | Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway.
Yan W, Shao Z, Li F, Niu L, Shi Y, Teng M, Li X. | 01/28/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| PTIP controls expression of PPARgamma and C/EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis. | Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.
Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K., Free PMC Article | 06/14/2010 |
| PTIP regulates 53BP1-dependent signaling pathway following DNA damage | PTIP regulates 53BP1 and SMC1 at the DNA damage sites.
Wu J, Prindle MJ, Dressler GR, Yu X., Free PMC Article | 01/21/2010 |
| subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage. | Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
Gong Z, Cho YW, Kim JE, Ge K, Chen J., Free PMC Article | 01/21/2010 |
| PTIP depletion from mammalian cells by RNAi reduced PCNA ubiquitination in response to DNA damage, and also decreased the recruitment to chromatin of polymerase eta and the recombination protein Rad51 | PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage.
Göhler T, Munoz IM, Rouse J, Blow JJ. | 01/21/2010 |
| Determination of a single ATM-phosphorylated residue in 53BP1--Ser25--that is required for binding of 53BP1 to hPTIP. | Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.
Munoz IM, Jowsey PA, Toth R, Rouse J., Free PMC Article | 01/21/2010 |
| identified tandem BRCT (BRCA1 carboxyl-terminal) domains in PTIP and in BRCA1 as phosphoserine- or phosphothreonine-specific binding modules that recognize substrates phosphorylated by the kinases ATM and ATR in response to gamma-irradiation | BRCT repeats as phosphopeptide-binding modules involved in protein targeting.
Manke IA, Lowery DM, Nguyen A, Yaffe MB. | 01/21/2010 |
| Without DNA damage agent treatment, endogenous PTIP associates with MLL3- and MLL4-containing histone H3 K4 methyltransferase complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, PA1 and JmjC domain-containing putative histone demethylase UTX. | PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K., Free PMC Article | 05/15/2007 |
| PTIP (PAXIP1) is a strong inhibitor of the trans-activation activities of Pax2A and Pax2B on the glucagon gene promoter and p8 binding to PTIP prevents inhibition of this promoter. | The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.
Hoffmeister A, Ropolo A, Vasseur S, Mallo GV, Bodeker H, Ritz-Laser B, Dressler GR, Vaccaro MI, Dagorn JC, Moreno S, Iovanna JL. | 01/21/2010 |
| hPTIP (PAXIP1) shows increased association with 53BP1 in response to ionizing radiation but not in response to other DNA-damaging agents. | Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.
Jowsey PA, Doherty AJ, Rouse J. | 01/21/2010 |