| Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP3 (IRBIT). | Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP(3) (IRBIT).
Goto JI, Fujii S, Fujiwara H, Mikoshiba K, Yamazaki Y., Free PMC Article | 05/14/2022 |
| Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO3(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2. | Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO(3)(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2.
Itoh R, Hatano N, Murakami M, Mitsumori K, Kawasaki S, Wakagi T, Kanzaki Y, Kojima H, Kawaai K, Mikoshiba K, Hamada K, Mizutani A., Free PMC Article | 12/18/2021 |
| IRBIT controlled five phosphorylation sites in NBCe1-B that determined both the active conformation of the transporter and its regulation by Cl(-) | Modulation of Cl(-) signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT.
Vachel L, Shcheynikov N, Yamazaki O, Fremder M, Ohana E, Son A, Shin DM, Yamazaki-Nakazawa A, Yang CR, Knepper MA, Muallem S., Free PMC Article | 11/9/2019 |
| NHERF1 mediates ANG II-induced activation of renal NHE3, which requires coordination between IRBIT and the NHERF1 PDZ1 domain in binding and transporting NHE3 | The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.
He P, Zhao L, No YR, Karvar S, Yun CC., Free PMC Article | 07/29/2017 |
| IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2. | IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues.
Ando H, Hirose M, Gainche L, Kawaai K, Bonneau B, Ijuin T, Itoh T, Takenawa T, Mikoshiba K., Free PMC Article | 06/28/2016 |
| IRBIT suppresses CaMKIIalpha activity and contributes to catecholamine homeostasis through TH phosphorylation. | IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation.
Kawaai K, Mizutani A, Shoji H, Ogawa N, Ebisui E, Kuroda Y, Wakana S, Miyakawa T, Hisatsune C, Mikoshiba K., Free PMC Article | 08/1/2015 |
| Irbit was sequestered by InsP3 receptors (IP3Rs) in the endoplasmic reticulum | Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.
Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S., Free PMC Article | 12/14/2013 |
| IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities | IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S., Free PMC Article | 04/30/2011 |
| Results sugest that IRBIT modulates the polyadenylation state of specific mRNAs, both by controlling the cytoplasmic/nuclear partitioning of Fip1 and by inhibiting PAP activity, in response to a stimulus that alters its phosphorylation state. | Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.
Kiefer H, Mizutani A, Iemura S, Natsume T, Ando H, Kuroda Y, Mikoshiba K., Free PMC Article | 01/21/2010 |
| Data show that pNBC1 activation requires the IRBIT PEST domain, while CFTR activation requires multiple domains, and suggest that IRBIT is a key coordinator of epithelial fluid and HCO3- secretion. | IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.
Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, Mizutani A, Mikoshiba K, Muallem S., Free PMC Article | 01/21/2010 |
| Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein. | Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney.
Gomi T, Takusagawa F, Nishizawa M, Agussalim B, Usui I, Sugiyama E, Taki H, Shinoda K, Hounoki H, Miwa T, Tobe K, Kobayashi M, Ishimoto T, Ogawa H, Mori H. | 01/21/2010 |
| phosphorylation of Ser71 and Ser74 were sufficient to enable inhibition of IP3 binding to the IP3R by IRBIT | Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor.
Devogelaere B, Beullens M, Sammels E, Derua R, Waelkens E, van Lint J, Parys JB, Missiaen L, Bollen M, De Smedt H., Free PMC Article | 01/21/2010 |
| IRBIT can directly interact with the IP3R, and that both the suppressor domain and the IP3-binding core of the IP3R are essential for a strong interaction. | Binding of IRBIT to the IP3 receptor: determinants and functional effects.
Devogelaere B, Nadif Kasri N, Derua R, Waelkens E, Callewaert G, Missiaen L, Parys JB, De Smedt H. | 01/21/2010 |