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    ATF6 activating transcription factor 6 [ Homo sapiens (human) ]

    Gene ID: 22926, updated on 6-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Arrestin beta-2 deficiency exacerbates periodontal inflammation by mediating activating transcription factor 6 activation and abnormal remodelling of the extracellular matrix.

    Arrestin beta-2 deficiency exacerbates periodontal inflammation by mediating activating transcription factor 6 activation and abnormal remodelling of the extracellular matrix.
    Feng M, Wang R, Deng L, Yang Y, Xia S, Liu F, Luo L.

    07/15/2024
    KCNH2A561V Heterozygous Mutation Inhibits KCNH2 Protein Expression via The Activation of UPR Mediated by ATF6.

    KCNH2A561V Heterozygous Mutation Inhibits KCNH2 Protein Expression via The Activation of UPR Mediated by ATF6.
    Chen B, Tan L, Chen D, Wang X, Liu J, Huang X, Wang Y, Huang S, Mao F, Lian J., Free PMC Article

    12/1/2023
    Reciprocal negative feedback regulation of ATF6alpha and PTEN promotes prostate cancer progression.

    Reciprocal negative feedback regulation of ATF6α and PTEN promotes prostate cancer progression.
    Feng T, Zhao R, Zhang H, Sun F, Hu J, Wang M, Qi M, Liu L, Gao L, Xiao Y, Zhen J, Chen W, Wang L, Han B., Free PMC Article

    09/19/2023
    Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression.

    Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression.
    Macke AJ, Pachikov AN, Divita TE, Morris ME, LaGrange CA, Holzapfel MS, Kubyshkin AV, Zyablitskaya EY, Makalish TP, Eremenko SN, Qiu H, Riethoven JM, Hemstreet GP, Petrosyan A., Free PMC Article

    09/6/2023
    Unfolded protein response factor ATF6 augments T helper cell responses and promotes mixed granulocytic airway inflammation.

    Unfolded protein response factor ATF6 augments T helper cell responses and promotes mixed granulocytic airway inflammation.
    Wu D, Zhang X, Zimmerly KM, Wang R, Wang C, Hunter R, Wu X, Campen M, Liu M, Yang XO., Free PMC Article

    08/16/2023
    Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6.

    Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6.
    Huang S, Xie Z, Han J, Wang H, Yang G, Li M, Zhou G, Wang Y, Li L, Li L, Zeng Z, Yu J, Chen M, Zhang S., Free PMC Article

    07/10/2023
    ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia.

    ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia.
    Xue X, Wu X, Liu L, Liu L, Zhu F., Free PMC Article

    07/7/2023
    Loss of ATF6alpha in a human carcinoma cell line is compensated not by its paralogue ATF6beta but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice.

    Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice.
    Jin S, Jin B, Ishikawa T, Ninagawa S, Okada T, Koyasu S, Harada H, Mori K., Free PMC Article

    02/24/2023
    ATF6-Mediated Signaling Contributes to PARP Inhibitor Resistance in Ovarian Cancer.

    ATF6-Mediated Signaling Contributes to PARP Inhibitor Resistance in Ovarian Cancer.
    McMellen A, Yamamoto TM, Qamar L, Sanders BE, Nguyen LL, Ortiz Chavez D, Bapat J, Berning A, Post MD, Johnson J, Behbakht K, Nurmemmedov E, Chuong EB, Bitler BG., Free PMC Article

    01/11/2023
    [Research progress of the unfolded protein response-activating transcription factor 6 pathway in ischemia-reperfusion injury post cardiac arrest].

    [Research progress of the unfolded protein response-activating transcription factor 6 pathway in ischemia-reperfusion injury post cardiac arrest].
    Yuan Z, Lu L, Yu Z.

    11/26/2022
    Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways.

    Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways.
    Li R, Zhou H, Li M, Mai Q, Fu Z, Jiang Y, Li C, Gao Y, Fan Y, Wu K, Costa CD, Sheng X, He Y, Li N., Free PMC Article

    08/13/2022
    ATF6alpha promotes prostate cancer progression by enhancing PLA2G4A-mediated arachidonic acid metabolism and protecting tumor cells against ferroptosis.

    ATF6α promotes prostate cancer progression by enhancing PLA2G4A-mediated arachidonic acid metabolism and protecting tumor cells against ferroptosis.
    Zhao R, Lv Y, Feng T, Zhang R, Ge L, Pan J, Han B, Song G, Wang L., Free PMC Article

    07/16/2022
    Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1alpha-XBP1 pathway.

    Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway.
    D'Amico D, Biondi O, Januel C, Bezier C, Sapaly D, Clerc Z, El Khoury M, Sundaram VK, Houdebine L, Josse T, Della Gaspera B, Martinat C, Massaad C, Weill L, Charbonnier F.

    07/9/2022
    JAK2/STAT3 inhibitor reduced 5-FU resistance and autophagy through ATF6-mediated ER stress.

    JAK2/STAT3 inhibitor reduced 5-FU resistance and autophagy through ATF6-mediated ER stress.
    Ma L, Wang Y.

    06/11/2022
    ATF6-Mediated Unfolded Protein Response Facilitates Adeno-associated Virus 2 (AAV2) Transduction by Releasing the Suppression of the AAV Receptor on Endoplasmic Reticulum Stress.

    ATF6-Mediated Unfolded Protein Response Facilitates Adeno-associated Virus 2 (AAV2) Transduction by Releasing the Suppression of the AAV Receptor on Endoplasmic Reticulum Stress.
    Cui M, Zhao Q, Wang J, Si Y, Cheng S, Ding W., Free PMC Article

    03/5/2022
    Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy.

    Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy.
    Yu M, Lun J, Zhang H, Wang L, Zhang G, Zhang H, Fang J.

    02/19/2022
    Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

    Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.
    Almasy KM, Davies JP, Plate L., Free PMC Article

    01/15/2022
    ATF6 is essential for human cone photoreceptor development.

    ATF6 is essential for human cone photoreceptor development.
    Kroeger H, Grandjean JMD, Chiang WJ, Bindels DD, Mastey R, Okalova J, Nguyen A, Powers ET, Kelly JW, Grimsey NJ, Michaelides M, Carroll J, Wiseman RL, Lin JH., Free PMC Article

    12/18/2021
    Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.

    Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.
    Vidal RL, Sepulveda D, Troncoso-Escudero P, Garcia-Huerta P, Gonzalez C, Plate L, Jerez C, Canovas J, Rivera CA, Castillo V, Cisternas M, Leal S, Martinez A, Grandjean J, Sonia D, Lashuel HA, Martin AJM, Latapiat V, Matus S, Sardi SP, Wiseman RL, Hetz C., Free PMC Article

    12/4/2021
    The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid.

    The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid.
    Ekiz-Yilmaz T, Isildar B, Gezer A, Kankaya D, Cansiz-Ersoz C, Kayisli UA, Guzel E.

    11/27/2021
    Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.

    Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.
    Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C., Free PMC Article

    11/13/2021
    Activating transcription factor 6 regulated cell growth, migration and inhibiteds cell apoptosis and autophagy via MAPK pathway in cervical cancer.

    Activating transcription factor 6 regulated cell growth, migration and inhibiteds cell apoptosis and autophagy via MAPK pathway in cervical cancer.
    Liu F, Chang L, Hu J.

    09/4/2021
    The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.

    The Ca(2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6.
    Parks SZ, Gao T, Jimenez Awuapura N, Ayathamattam J, Chabosseau PL, Kalvakolanu DV, Valdivia HH, Rutter GA, Leclerc I.

    07/17/2021
    The role of activating transcription factor 6 in hydroxycamptothecin-induced fibroblast autophagy and apoptosis.

    The role of activating transcription factor 6 in hydroxycamptothecin-induced fibroblast autophagy and apoptosis.
    Tao J, Chen H, Li X, Wang J., Free PMC Article

    07/17/2021
    OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress.

    OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress.
    Zhang HH, Li C, Ren JW, Liu L, Du XH, Gao J, Liu T, Li SZ., Free PMC Article

    06/19/2021
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