| End-binding protein 1 regulates the metabolic fate of CD4[+] T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network. | End-binding protein 1 regulates the metabolic fate of CD4(+) T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network.
Gómez-Morón Á, Requena S, Pertusa C, Lozano-Prieto M, Calzada-Fraile D, Scagnetti C, Sánchez-García I, Calero-García AA, Izquierdo M, Martín-Cófreces NB., Free PMC Article | 08/4/2023 |
| Kinetochore-microtubule attachment in human cells is regulated by the interaction of a conserved motif of Ska1 with EB1. | Kinetochore-microtubule attachment in human cells is regulated by the interaction of a conserved motif of Ska1 with EB1.
Radhakrishnan RM, Kizhakkeduth ST, Nair VM, Ayyappan S, Lakshmi RB, Babu N, Prasannajith A, Umeda K, Vijayan V, Kodera N, Manna TK., Free PMC Article | 03/8/2023 |
| Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant. | Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant.
Dema A, Charafeddine R, Rahgozar S, van Haren J, Wittmann T., Free PMC Article | 02/23/2023 |
| Phase separation of EB1 guides microtubule plus-end dynamics. | Phase separation of EB1 guides microtubule plus-end dynamics.
Song X, Yang F, Yang T, Wang Y, Ding M, Li L, Xu P, Liu S, Dai M, Chi C, Xiang S, Xu C, Li D, Wang Z, Li L, Hill DL, Fu C, Yuan K, Li P, Zang J, Hou Z, Jiang K, Shi Y, Liu X, Yao X. | 01/28/2023 |
| CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration. | CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration.
Morales X, Peláez R, Garasa S, Ortiz de Solórzano C, Rouzaut A., Free PMC Article | 01/22/2022 |
| Redox-dependent regulation of end-binding protein 1 activity by glutathionylation. | Redox-dependent regulation of end-binding protein 1 activity by glutathionylation.
Chen M, Wang J, Yang Y, Zhong T, Zhou P, Ma H, Li J, Li D, Zhou J, Xie S, Liu M. | 12/11/2021 |
| EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK. | EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK.
Chanez B, Ostacolo K, Badache A, Thuault S., Free PMC Article | 10/16/2021 |
| EB1 Directly Regulates APC-Mediated Actin Nucleation. | EB1 Directly Regulates APC-Mediated Actin Nucleation.
Juanes MA, Fees CP, Hoeprich GJ, Jaiswal R, Goode BL., Free PMC Article | 08/28/2021 |
| MAPRE1 promotes cell cycle progression of hepatocellular carcinoma cells by interacting with CDK2. | MAPRE1 promotes cell cycle progression of hepatocellular carcinoma cells by interacting with CDK2.
Liang XH, Feng ZP, Liu FQ, Yan R, Yin LY, Shen H, Lu HL. | 06/26/2021 |
| Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis. | Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis.
Aiyama T, Orimo T, Yokoo H, Ohata T, Hatanaka KC, Hatanaka Y, Fukai M, Kamiyama T, Taketomi A., Free PMC Article | 11/21/2020 |
| A crucial role for EB1 phosphorylation in the regulation of mitotic spindle orientation and cell division. | Regulation of mitotic spindle orientation by phosphorylation of end binding protein 1.
Chen M, Cao Y, Dong D, Zhang Z, Zhang Y, Chen J, Luo Y, Chen Q, Xiao X, Zhou J, Xie W, Li D, Xie S, Liu M. | 06/20/2020 |
| GTP-binding may regulate the functions of EB1 on the cellular microtubules. | GTP-binding facilitates EB1 recruitment onto microtubules by relieving its auto-inhibition.
Gireesh KK, Shine A, Lakshmi RB, Vijayan V, Manna TK., Free PMC Article | 10/12/2019 |
| studies emphasize the importance of studying combinatorial expression of EB1 and ATIP3 genes and proteins rather than each biomarker alone. A population of highly aggressive breast tumors expressing high-EB1/low-ATIP3 may be considered for the development of new molecular therapies. | Combinatorial expression of microtubule-associated EB1 and ATIP3 biomarkers improves breast cancer prognosis.
Rodrigues-Ferreira S, Nehlig A, Monchecourt C, Nasr S, Fuhrmann L, Lacroix-Triki M, Garberis I, Scott V, Delaloge S, Pistilli B, Vielh P, Dubois T, Vincent-Salomon A, André F, Nahmias C. | 06/15/2019 |
| STIM1-EB1 interaction shapes the kinetics and amplitude of local store-operated Ca(2+) entry. | EB1 binding restricts STIM1 translocation to ER-PM junctions and regulates store-operated Ca(2+) entry.
Chang CL, Chen YJ, Quintanilla CG, Hsieh TS, Liou J., Free PMC Article | 05/18/2019 |
| finding that CLIP-170 has multiple non-CAP-Gly EB1-binding modules may explain why autoinhibition of CLIP-170 GAP-Gly domains does not fully abrogate its microtubule plus-end localization. This work expands our understanding of EB1-binding motifs and their multivalent networks. | Mapping multivalency in the CLIP-170-EB1 microtubule plus-end complex.
Chen Y, Wang P, Slep KC., Free PMC Article | 04/20/2019 |
| Developed a photo-inactivated EB1 variant (pi-EB1) by inserting a blue-light-sensitive protein-protein interaction module between the microtubule-binding and +TIP-binding domains of EB1. Blue-light-mediated pi-EB1 photodissociation results in rapid +TIP complex disassembly, and acutely and reversibly attenuates microtubule growth independent of microtubule end association of the microtubule polymerase CKAP5. | Local control of intracellular microtubule dynamics by EB1 photodissociation.
van Haren J, Charafeddine RA, Ettinger A, Wang H, Hahn KM, Wittmann T., Free PMC Article | 04/13/2019 |
| EB1 and dynein mediate migration in 3D by promoting microtubule dynamics, through the activity of RhoA, in microtubule-rich pseudopodial dendritic protrusions that drive cell migration in 3D | EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration.
Jayatilaka H, Giri A, Karl M, Aifuwa I, Trenton NJ, Phillip JM, Khatau S, Wirtz D., Free PMC Article | 11/17/2018 |
| End-binding protein 1 (EB1) depletion results in a significant reduction of spindle and kinetochore-associated protein 1 (Ska1) recruitment onto microtubules and defects in mitotic chromosome alignment. | EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice.
Thomas GE, Bandopadhyay K, Sutradhar S, Renjith MR, Singh P, Gireesh KK, Simon S, Badarudeen B, Gupta H, Banerjee M, Paul R, Mitra J, Manna TK., Free PMC Article | 09/29/2018 |
| The cytotoxicity induced by EB1 gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase..this signaling cascade, however not nuclear factor-kappaB-mediated signaling, induced the expression of cyclooxygenase-2, a key effector of apoptotic death. | Knockdown of end-binding protein 1 induces apoptosis in radioresistant A549 lung cancer cells via p38 kinase-dependent COX-2 upregulation.
Baek JH, Yim JH, Song JY, Um HD, Park JK, Park IC, Kim JS, Lee CW, Hong EH, Kim EH, Hwang SG. | 08/25/2018 |
| ASK1- induced phosphorylation of EB1 not only increases its plus end-tracking ability, but also promotes its recruitment of CLIP170 and p150glued to astral microtubules. | Phosphorylation of EB1 regulates the recruitment of CLIP-170 and p150glued to the plus ends of astral microtubules.
Ran J, Luo Y, Zhang Y, Yang Y, Chen M, Liu M, Li D, Zhou J., Free PMC Article | 02/24/2018 |
| A novel EB1 acetylation site regulates the dynamic structure of microtubules. | Characterization of a novel EB1 acetylation site important for the regulation of microtubule dynamics and cargo recruitment.
Xie S, Yang Y, Lin X, Zhou J, Li D, Liu M. | 12/16/2017 |
| increased peripheral EB1 distribution is a critical component of the Rac1-mediated pathway and peripheral cytoskeletal remodeling essential for agonist-induced endothelial cell barrier enhancement. | Role of End Binding Protein-1 in endothelial permeability response to barrier-disruptive and barrier-enhancing agonists.
Tian X, Ohmura T, Shah AS, Son S, Tian Y, Birukova AA., Free PMC Article | 12/2/2017 |
| In addition, EB1 phosphorylation at Y247 by Src enhances the rate of microtubule catastrophe and significantly stimulates cell migration. These findings thus demonstrate that the Src-EB1 axis plays a crucial role in regulating the crosstalk between microtubules and focal adhesions to promote cell migration. | Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration.
Zhang Y, Luo Y, Lyu R, Chen J, Liu R, Li D, Liu M, Zhou J., Free PMC Article | 10/14/2017 |
| EB1 and EB3 thus affect multiple interphase processes and have a major impact on microtubule minus end organization. | EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.
Yang C, Wu J, de Heus C, Grigoriev I, Liv N, Yao Y, Smal I, Meijering E, Klumperman J, Qi RZ, Akhmanova A., Free PMC Article | 10/7/2017 |
| noncentrosomal MTs regulate autophagy through a cross-talk between CAMSAP2 and EB1 | Noncentrosomal microtubules regulate autophagosome transport through CAMSAP2-EB1 cross-talk.
Wei J, Xu H, Meng W. | 10/7/2017 |