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    MMRN1 multimerin 1 [ Homo sapiens (human) ]

    Gene ID: 22915, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways.

    Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways.
    Saini A, Kumar V, Tomar AK, Sharma A, Yadav S.

    11/6/2023
    Analysis of Multimerin 1 (MMRN1) expression in ovarian cancer.

    Analysis of Multimerin 1 (MMRN1) expression in ovarian cancer.
    Saini A, Chandra KB, Kumar V, Mathur SR, Sharma JB, Kumar S, Yadav S.

    05/29/2021
    MMRN1 expression in healthy human palatal mucosa is strongly negatively correlated with serum cotinine levels.

    Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.
    Wang Y, Anderson EP, Tatakis DN.

    11/18/2019
    VWF binding to MMRN1 was enhanced by shear exposure and ristocetin, and required VWF A1A2A3 region, specifically the A1 and A3 domains.

    The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.
    Parker DN, Tasneem S, Farndale RW, Bihan D, Sadler JE, Sebastian S, de Groot PG, Hayward CP., Free PMC Article

    01/20/2018
    Lower levels of anti-elastin are related to CAD [ coronary artery disease ]

    Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis.
    Lee SH, Shin K, Park S, Kang SM, Choi D, Lee SH, Lee SH., Free PMC Article

    05/28/2016
    our studies identify MMRN1 expression as a novel biomarker that may refine acute myelogenous leukemia risk stratification.

    Multimerin-1 (MMRN1) as Novel Adverse Marker in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.
    Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB., Free PMC Article

    05/14/2016
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Replication of GWAS associations for GAK and MAPT in Parkinson's disease.
    Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B.

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    04/7/2010
    MMRN1 supported the adhesion of activated, but not resting, washed platelets over a wide range of shear rates

    Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear.
    Tasneem S, Adam F, Minullina I, Pawlikowska M, Hui SK, Zheng S, Miller JL, Hayward CP.

    01/21/2010
    The MMRN1 binding site was located in Factor V.

    Location of the multimerin 1 binding site in coagulation factor V: an update.
    Jeimy SB, Quinn-Allen MA, Fuller N, Kane WH, Hayward CP., Free PMC Article

    01/21/2010
    Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation.

    Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation.
    Jeimy SB, Fuller N, Tasneem S, Segers K, Stafford AR, Weitz JI, Camire RM, Nicolaes GA, Hayward CP.

    01/21/2010
    Observational study of genotype prevalence. (HuGE Navigator)

    Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer.
    Mangold E, Pagenstecher C, Friedl W, Mathiak M, Buettner R, Engel C, Loeffler M, Holinski-Feder E, Müller-Koch Y, Keller G, Schackert HK, Krüger S, Goecke T, Moeslein G, Kloor M, Gebert J, Kunstmann E, Schulmann K, Rüschoff J, Propping P.

    03/13/2008
    multimerin 1 has a role in delivering and localizing factor V onto platelets prior to prothrombinase assembly

    Identification of the MMRN1 binding region within the C2 domain of human factor V.
    Jeimy SB, Woram RA, Fuller N, Quinn-Allen MA, Nicolaes GA, Dahlbäck B, Kane WH, Hayward CP.

    01/21/2010
    disulfide-linked complexes of multimerin and factor V in platelets could be important for modulating the function of platelet factor V and its delivery onto activated platelets

    Human platelets contain forms of factor V in disulfide-linkage with multimerin.
    Hayward CP, Fuller N, Zheng S, Adam F, Jeimy SB, Horsewood I, Quinn-Allen MA, Kane WH.

    01/21/2010
    MMRN1 is a ligand for alphaIIbbeta3 and alphavbeta3

    Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alphaIIbbeta3 and alphavbeta3.
    Adam F, Zheng S, Joshi N, Kelton DS, Sandhu A, Suehiro Y, Jeimy SB, Santos AV, Massé JM, Kelton JG, Cramer EM, Hayward CP.

    01/21/2010
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