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    KLRK1 killer cell lectin like receptor K1 [ Homo sapiens (human) ]

    Gene ID: 22914, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Lower NKG2D expression in hepatic natural killer cells predicts poorer prognosis for chronic hepatitis B patients with cirrhosis.

    Lower NKG2D expression in hepatic natural killer cells predicts poorer prognosis for chronic hepatitis B patients with cirrhosis.
    Ma Y, Ping D, Huang K, Tao Y, Peng Y, Sun X, Liu C.

    06/11/2024
    Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses.

    Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses.
    Hartmann JA, Cardoso MR, Talarico MCR, Kenney DJ, Leone MR, Reese DC, Turcinovic J, O'Connell AK, Gertje HP, Marino C, Ojeda PE, De Paula EV, Orsi FA, Velloso LA, Cafiero TR, Connor JH, Ploss A, Hoelzemer A, Carrington M, Barczak AK, Crossland NA, Douam F, Boucau J, Garcia-Beltran WF.,

    05/29/2024
    Donor NKG2D rs1049174 polymorphism predicts hematopoietic recovery and event-free survival after single-unit cord blood transplantation in adults.

    Donor NKG2D rs1049174 polymorphism predicts hematopoietic recovery and event-free survival after single-unit cord blood transplantation in adults.
    Konuma T, Hamatani-Asakura M, Monna-Oiwa M, Kato S, Isobe M, Yokoyama K, Nannya Y, Takahashi S.

    04/11/2024
    Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease.

    Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease.
    Fernández-Soto D, García-Jiménez ÁF, Casasnovas JM, Valés-Gómez M, Reyburn HT., Free PMC Article

    02/29/2024
    Progressive accumulation of hyperinflammatory NKG2D[low] NK cells in early childhood severe atopic dermatitis.

    Progressive accumulation of hyperinflammatory NKG2D(low) NK cells in early childhood severe atopic dermatitis.
    Ochayon DE, DeVore SB, Chang WC, Krishnamurthy D, Seelamneni H, Grashel B, Spagna D, Andorf S, Martin LJ, Biagini JM, Waggoner SN, Khurana Hershey GK.,

    02/27/2024
    UCA1 Inhibits NKG2D-mediated Cytotoxicity of NK Cells to Breast Cancer.

    UCA1 Inhibits NKG2D-mediated Cytotoxicity of NK Cells to Breast Cancer.
    Yin JY, Zhou Y, Ding XM, Gong RZ, Zhou Y, Hu HY, Liu Y, Lv XB, Zhang B.

    02/7/2024
    Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis.

    Novel Association of KLRC4-KLRK1 Gene Polymorphisms with Susceptibility and Progression of Antithyroid Drug-Induced Agranulocytosis.
    He Y, Ma P, Luo Y, Gong X, Gao J, Sun Y, Chen P, Zhang S, Tian Y, Shi B, Zhang B.

    02/1/2024
    MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.

    MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.
    Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR.,

    01/5/2024
    Autophagy-mediated NKG2D internalization impairs NK cell function and exacerbates radiation pneumonitis.

    Autophagy-mediated NKG2D internalization impairs NK cell function and exacerbates radiation pneumonitis.
    Wang R, Ma X, Zhang X, Jiang D, Mao H, Li Z, Tian Y, Cheng B., Free PMC Article

    12/20/2023
    NKG2D receptor regulates CD4[+]T cell differentiation via interaction with dendritic cells in patients with juvenile idiopathic arthritis.

    NKG2D receptor regulates CD4(+)T cell differentiation via interaction with dendritic cells in patients with juvenile idiopathic arthritis.
    Zhou J, Wang J, Tao L, Liu M, Tang X, Zhu X.

    11/8/2023
    Association of inhibitory NKG2A and activating NKG2D natural killer cell receptor genes with resistance to SARS-CoV-2 infection in a western Indian population.

    Association of inhibitory NKG2A and activating NKG2D natural killer cell receptor genes with resistance to SARS-CoV-2 infection in a western Indian population.
    Tripathy AS, Wagh P, Akolkar K, Walimbe AM, Potdar VA, Choudhary ML, Kadgi N, Nakate L, Abraham P.

    10/30/2023
    Association between NKG2/KLR gene variants and epilepsy in Autism Spectrum Disorder.

    Association between NKG2/KLR gene variants and epilepsy in Autism Spectrum Disorder.
    Kaminski VL, Kulmann-Leal B, Tyska-Nunes GL, Beltrame BP, Riesgo RDS, Schüler-Faccini L, Roman T, Schuch JB, Chies JAB.

    10/24/2023
    IL-17a-producing gammadeltaT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia.

    IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia.
    Cui TX, Brady AE, Zhang YJ, Anderson C, Popova AP., Free PMC Article

    09/29/2023
    Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality.

    Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality.
    Khaleafi R, Zeleznjak J, Cordela S, Drucker S, Rovis TL, Jonjic S, Bar-On Y., Free PMC Article

    09/28/2023
    NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis.

    NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis.
    Sacramento LA, Farias Amorim C, Campos TM, Saldanha M, Arruda S, Carvalho LP, Beiting DP, Carvalho EM, Novais FO, Scott P., Free PMC Article

    09/20/2023
    Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis.

    Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis.
    Tan H, Yang H, Qian J, Liu S, Yan D, Wei L, Liu W., Free PMC Article

    08/14/2023
    Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation.

    Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation.
    Petersdorf EW, McKallor C, Malkki M, He M, Spellman SR, Hsu KC, Strong RK, Gooley T, Stevenson P., Free PMC Article

    06/22/2023
    INTERLEUKIN-6 AND NKG2D AS PROGNOSTIC FACTORS IN IRAQI FEMALES WITH PITUITARY GAND ADENOMA: A LONGITUDINAL STUDY.

    INTERLEUKIN-6 AND NKG2D AS PROGNOSTIC FACTORS IN IRAQI FEMALES WITH PITUITARY GAND ADENOMA: A LONGITUDINAL STUDY.
    Alfadhel SM, Abeid ST, Hadi NR.

    03/10/2023
    NKG2D signaling shifts the balance of CD8 T cells from single cytokine- to polycytokine-producing effector cells.

    NKG2D signaling shifts the balance of CD8 T cells from single cytokine- to polycytokine-producing effector cells.
    Kohlhapp FJ, O'Sullivan JA, Moore TV, Zloza A, Guevara-Patiño JA., Free PMC Article

    03/9/2023
    NKG2D engagement on human NK cells leads to DNAM-1 hypo-responsiveness through different converging mechanisms.

    NKG2D engagement on human NK cells leads to DNAM-1 hypo-responsiveness through different converging mechanisms.
    Milito ND, Zingoni A, Stabile H, Soriani A, Capuano C, Cippitelli M, Gismondi A, Santoni A, Paolini R, Molfetta R.

    02/14/2023
    IL-15 induced bystander activation of CD8[+] T cells may mediate endothelium injury through NKG2D in Hantaan virus infection.

    IL-15 induced bystander activation of CD8(+) T cells may mediate endothelium injury through NKG2D in Hantaan virus infection.
    Zhang X, Zhang Y, Liu H, Tang K, Zhang C, Wang M, Xue M, Jia X, Hu H, Li N, Zhuang R, Jin B, Zhang F, Zhang Y, Ma Y., Free PMC Article

    01/14/2023
    SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D.

    SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D.
    Lee MJ, Leong MW, Rustagi A, Beck A, Zeng L, Holmes S, Qi LS, Blish CA., Free PMC Article

    01/11/2023
    NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.

    NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
    Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR., Free PMC Article

    12/31/2022
    STAT1 is associated with NK cell dysfunction by downregulating NKG2D transcription in chronic HBV-infected patients.

    STAT1 is associated with NK cell dysfunction by downregulating NKG2D transcription in chronic HBV-infected patients.
    Huang X, Mo Q, Fu T, Liu Y, Diao B.

    12/3/2022
    GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells.

    GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells.
    Kosta A, Mekhloufi A, Lucantonio L, Zingoni A, Soriani A, Cippitelli M, Gismondi A, Fazio F, Petrucci MT, Santoni A, Stabile H, Fionda C., Free PMC Article

    09/3/2022
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