| Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury. | Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Hasuzawa N, Tatsushima K, Wang L, Kabashima M, Tokubuchi R, Nagayama A, Ashida K, Ogawa Y, Moriyama Y, Nomura M., Free PMC Article | 12/11/2021 |
| VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation. | VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation.
Inoue A, Nakao-Kuroishi K, Kometani-Gunjigake K, Mizuhara M, Shirakawa T, Ito-Sago M, Yasuda K, Nakatomi M, Matsubara T, Tada-Shigeyama Y, Morikawa K, Kokabu S, Kawamoto T., Free PMC Article | 11/6/2021 |
| Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression. | Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression.
Paniagua-Herranz L, Menéndez-Méndez A, Gómez-Villafuertes R, Olivos-Oré LA, Biscaia M, Gualix J, Pérez-Sen R, Delicado EG, Artalejo AR, Miras-Portugal MT, Ortega F., Free PMC Article | 09/11/2021 |
| Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation. | Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.
Mihara H, Boudaka A, Tominaga M, Sugiyama T., Free PMC Article | 08/13/2020 |
| expression of TRPV4 and VNUT in normal human gastrointestinal cell derived cell lines | Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
Mihara H, Uchida K, Koizumi S, Moriyama Y., Free PMC Article | 04/6/2019 |
| Data (including data from studies using knockout mice) suggest that Vnut/Slc17a9 localized in tertiary/secretory granules of neutrophils is responsible for vesicular ATP release and subsequent neutrophil migration/infiltration. | Vesicular nucleotide transporter mediates ATP release and migration in neutrophils.
Harada Y, Kato Y, Miyaji T, Omote H, Moriyama Y, Hiasa M., Free PMC Article | 01/12/2019 |
| FLX-induced anti-depressive behavior was decreased in astrocyte-selective VNUT-knockout mice or when VNUT was deleted in mice, but it was increased when astrocyte-selective VNUT was overexpressed in mice | Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.
Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, Takeda A, Le HPN, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S., Free PMC Article | 10/13/2018 |
| VNUT is necessary for exocytotic ATP release from spinal dorsal horn neurons which contributes to neuropathic pain. | Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain.
Masuda T, Ozono Y, Mikuriya S, Kohro Y, Tozaki-Saitoh H, Iwatsuki K, Uneyama H, Ichikawa R, Salter MW, Tsuda M, Inoue K., Free PMC Article | 09/8/2018 |
| This study provides a molecular mechanism for lysosomal ATP transport mediated by SLC17A9 and also suggests a regulatory mechanism of lysosomal P2X4 by SLC17A9 | Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V-ATPase generated voltage gradient as the driving force.
Zhong XZ, Cao Q, Sun X, Dong XP., Free PMC Article | 09/2/2017 |
| clock genes exist in the mouse bladder mucosa and regulate exact circadian gene expression in mice | Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.
Ihara T, Mitsui T, Nakamura Y, Kira S, Nakagomi H, Sawada N, Hirayama Y, Shibata K, Shigetomi E, Shinozaki Y, Yoshiyama M, Andersson KE, Nakao A, Takeda M, Koizumi S., Free PMC Article | 08/12/2017 |
| Functional VNUT is expressed in the rodent retina, and these results suggest that ATP is released from photoreceptor cells, bipolar cells, amacrine cells, and astrocytes as well as Muller cells to initiate purinergic chemical transmission | Expression of Vesicular Nucleotide Transporter in the Mouse Retina.
Moriyama S, Hiasa M. | 01/14/2017 |
| VNUT expression was significantly increased during glaucoma progression in a mouse model. | Increased levels of extracellular ATP in glaucomatous retinas: Possible role of the vesicular nucleotide transporter during the development of the pathology.
Pérez de Lara MJ, Guzmán-Aránguez A, de la Villa P, Díaz-Hernández JI, Miras-Portugal MT, Pintor J., Free PMC Article | 06/28/2016 |
| In vitro expression of VNUT decreases neuritogenesis in N2a cells differentiated by retinoic acid treatment | The vesicular nucleotide transporter (VNUT) is involved in the extracellular ATP effect on neuronal differentiation.
Menéndez-Méndez A, Díaz-Hernández JI, Miras-Portugal MT., Free PMC Article | 02/20/2016 |
| These results demonstrated an essential role of VNUT in vesicular storage and release of ATP in neuroendocrine cells in vivo and suggest that vesicular ATP and/or its degradation products act as feedback regulators in catecholamine and insulin secretion. | Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity.
Sakamoto S, Miyaji T, Hiasa M, Ichikawa R, Uematsu A, Iwatsuki K, Shibata A, Uneyama H, Takayanagi R, Yamamoto A, Omote H, Nomura M, Moriyama Y., Free PMC Article | 10/31/2015 |
| The VNUT-dependent ATP release pathway is associated with an induced secretion process and downstream purinergic signalling. | Role of vesicular nucleotide transporter VNUT (SLC17A9) in release of ATP from AR42J cells and mouse pancreatic acinar cells.
Haanes KA, Kowal JM, Arpino G, Lange SC, Moriyama Y, Pedersen PA, Novak I., Free PMC Article | 06/20/2015 |
| These results demonstrate that intestinal L cells express VNUT (vesicular nucleotide transporter )and suggest that L cells are purinergic in nature and secrete nucleotides. | Immunological identification of vesicular nucleotide transporter in intestinal L cells.
Harada Y, Hiasa M. | 02/28/2015 |
| VNUT mediates transport of ATP into synaptic vesicles of hippocampal neurons. | Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release.
Larsson M, Sawada K, Morland C, Hiasa M, Ormel L, Moriyama Y, Gundersen V. | 08/11/2012 |
| the existence of an SLC17A9-dependent ATP-enriched vesicular pool in biliary epithelium that undergoes regulated exocytosis to initiate purinergic signaling. | Regulation of purinergic signaling in biliary epithelial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles.
Sathe MN, Woo K, Kresge C, Bugde A, Luby-Phelps K, Lewis MA, Feranchak AP., Free PMC Article | 01/28/2012 |
| analysis of involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation | Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation.
Tokunaga A, Tsukimoto M, Harada H, Moriyama Y, Kojima S., Free PMC Article | 06/28/2010 |
| SLC17A9 protein acts as a vesicular nucleotide transporter (VNUT) and plays an essential role in vesicular storage of ATP in the ATP-secreting cells | Identification of a vesicular nucleotide transporter.
Sawada K, Echigo N, Juge N, Miyaji T, Otsuka M, Omote H, Yamamoto A, Moriyama Y., Free PMC Article | 01/21/2010 |