| CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation. | CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.
Zhuang W, Zhou J, Zhong L, Lv J, Zhong X, Liu G, Xie L, Wang C, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Xie X, Du C., Free PMC Article | 09/20/2023 |
| IL-10 in combination with IL-12 and TNF-alpha attenuates CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway. | IL-10 in combination with IL-12 and TNF-α attenuates CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with Staphylococcus aureus through the TNFR1-IL-1R-NF-κB pathway.
Dutta P, Bishayi B. | 06/19/2023 |
| CXCR1 and its downstream NF-kappaB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury. | CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury.
Xiao G, Liu J, Wang H, He S, Liu J, Fan G, Lyu M, Zhu Y., Free PMC Article | 11/12/2022 |
| MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury. | MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury.
Le A, Wu Y, Liu W, Wu C, Hu P, Zou J, Kuang L., Free PMC Article | 02/5/2022 |
| CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity. | CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Teijeira Á, Garasa S, Gato M, Alfaro C, Migueliz I, Cirella A, de Andrea C, Ochoa MC, Otano I, Etxeberria I, Andueza MP, Nieto CP, Resano L, Azpilikueta A, Allegretti M, de Pizzol M, Ponz-Sarvisé M, Rouzaut A, Sanmamed MF, Schalper K, Carleton M, Mellado M, Rodriguez-Ruiz ME, Berraondo P, Perez-Gracia JL, Melero I. | 11/21/2020 |
| Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor. | Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor.
Hosoki K, Rajarathnam K, Sur S., Free PMC Article | 09/26/2020 |
| mRNA and protein expression of CXCR1 was higher in the liver and sWAT tissue of db/db mice than db/m mice. | The antagonist of CXCR1 and CXCR2 protects db/db mice from metabolic diseases through modulating inflammation.
Cui S, Qiao L, Yu S, Men L, Li Y, Li F, Du J. | 04/18/2020 |
| these studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for cystic fibrosis, chronic obstructive pulmonary disease and other infectious lung diseases | CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense.
Carevic M, Öz H, Fuchs K, Laval J, Schroth C, Frey N, Hector A, Bilich T, Haug M, Schmidt A, Autenrieth SE, Bucher K, Beer-Hammer S, Gaggar A, Kneilling M, Benarafa C, Gao JL, Murphy PM, Schwarz S, Moepps B, Hartl D., Free PMC Article | 09/23/2017 |
| CXCR1 and CXCR2 regulate hepatocyte exosome release. The mechanism utilized by CXCR1 remains elusive, but CXCR2 appears to modulate Nsm activity and resultant production of ceramide to control exosome release. CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect. | Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes.
Nojima H, Konishi T, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E, Lentsch AB., Free PMC Article | 07/29/2017 |
| These data demonstrate a biological function for mouse Cxcr1 in vivo and indicate that CXCR1-dependent neutrophil effector function is a critical innate protective mechanism of fungal clearance and host survival in systemic candidiasis. | CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.
Swamydas M, Gao JL, Break TJ, Johnson MD, Jaeger M, Rodriguez CA, Lim JK, Green NM, Collar AL, Fischer BG, Lee CC, Perfect JR, Alexander BD, Kullberg BJ, Netea MG, Murphy PM, Lionakis MS., Free PMC Article | 10/22/2016 |
| in view of recently-published experimental data obtained in NOD mice, we argue for possible Cxcr1 involvement in type 1 diabetes pathogenesi | Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes.
Haurogné K, Pavlovic M, Rogniaux H, Bach JM, Lieubeau B., Free PMC Article | 05/7/2016 |
| expressed 33-110-fold higher in hepatocellular carcinoma polymorphonuclear myeloid-derived suppressor cells | Subsets of myeloid-derived suppressor cells in hepatocellular carcinoma express chemokines and chemokine receptors differentially.
Zhao W, Xu Y, Xu J, Wu D, Zhao B, Yin Z, Wang X. | 03/5/2016 |
| CXCR1 expression is induced in staphylococcus aureus-infected macrophages but not in control macrophages. | Expression of CXCR1 (interleukin-8 receptor) in murine macrophages after staphylococcus aureus infection and its possible implication on intracellular survival correlating with cytokines and bacterial anti-oxidant enzymes.
Bishayi B, Bandyopadhyay D, Majhi A, Adhikary R. | 11/28/2015 |
| Pharmacologic blockade of CXCR1/2 as well as genetic deletion of NAP-2 markedly reduced leukocyte shape change and intrathrombus migration. | The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.
Ghasemzadeh M, Kaplan ZS, Alwis I, Schoenwaelder SM, Ashworth KJ, Westein E, Hosseini E, Salem HH, Slattery R, McColl SR, Hickey MJ, Ruggeri ZM, Yuan Y, Jackson SP., Free PMC Article | 08/3/2013 |
| Blockade of the CXCL1-CXCR1/2 axis in mice improved intrahepatic islet engraftment. The CXCR1/2-mediated pathway is a regulator of islet damage. | CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.
Citro A, Cantarelli E, Maffi P, Nano R, Melzi R, Mercalli A, Dugnani E, Sordi V, Magistretti P, Daffonchio L, Ruffini PA, Allegretti M, Secchi A, Bonifacio E, Piemonti L., Free PMC Article | 02/2/2013 |
| Upon activation by CXCL8, CXCR1 predominantly couples to G protein-coupled receptor kinase (GRK)2 to modulate leukocyte functions. | The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions.
Raghuwanshi SK, Su Y, Singh V, Haynes K, Richmond A, Richardson RM., Free PMC Article | 12/8/2012 |
| Xiaotan Sanjie Decoction XTSJD can decrease the protein expressions of IL-8 and its receptors CXCR1/CXCR2 in tumor xenografts and gastric tissue adjacent to the tumor. | [Effects of Xiaotan Sanjie Decoction on expressions of interleukin-8 and its receptors in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice].
Ju DW, Wei PK, Lin HM, Sun DZ, Yu S, Xiu LJ. | 03/10/2012 |
| data suggest that CXCR1 does not mediate the proliferative effects of ELR+ CXC chemokines during liver regeneration after partial hepatectomy | CXCR1 deficiency does not alter liver regeneration after partial hepatectomy in mice.
Sakai N, Kuboki S, Van Sweringen HL, Tevar AD, Schuster R, Blanchard J, Edwards MJ, Lentsch AB., Free PMC Article | 10/15/2011 |
| CXCR1 expression is induced in hepatocytes after injury. Furthermore, the data suggest that CXCR1 has divergent effects from CXCR2 and appears to facilitate repair and regenerative responses after I/R injury. | CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.
Clarke C, Kuboki S, Sakai N, Kasten KR, Tevar AD, Schuster R, Blanchard J, Caldwell CC, Edwards MJ, Lentsch AB., Free PMC Article | 03/5/2011 |
| CX3CL1-CX3CR1 axis can regulate the expression of iNOS, a crucial mediator of DSS-induced colitis. | Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice.
Kostadinova FI, Baba T, Ishida Y, Kondo T, Popivanova BK, Mukaida N. | 07/19/2010 |
| Blockade of CXCR1/CXCR2 receptors inhibits neutrophil recruitment by inhibiting the adhesion of neutrophils to synovial microvessels. As a consequence, there is decreased local cytokine production and ameloriation of arthritis in the tissue. | The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature.
Coelho FM, Pinho V, Amaral FA, Sachs D, Costa VV, Rodrigues DH, Vieira AT, Silva TA, Souza DG, Bertini R, Teixeira AL, Teixeira MM. | 01/21/2010 |
| CXCR1 cleavage on neutrophils disables bacterial killing in cystic fibrosis lung disease | Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease.
Hartl D, Latzin P, Hordijk P, Marcos V, Rudolph C, Woischnik M, Krauss-Etschmann S, Koller B, Reinhardt D, Roscher AA, Roos D, Griese M. | 01/21/2010 |
| mCXCR1 may mediate the recruitment of neutrophils to the inflammation site under certain infections | Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1.
Fu W, Zhang Y, Zhang J, Chen WF. | 01/21/2010 |
| The gene encoding mCXCR1-like was mapped to mouse chromosome 1 and its genomic organization was determined to be very similar to the organization of the gene encoding hCXCR1. | A homolog of the human chemokine receptor CXCR1 is expressed in the mouse.
Moepps B, Nuesseler E, Braun M, Gierschik P. | 01/21/2010 |
| CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8 in mouse | Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.
Fan X, Patera AC, Pong-Kennedy A, Deno G, Gonsiorek W, Manfra DJ, Vassileva G, Zeng M, Jackson C, Sullivan L, Sharif-Rodriguez W, Opdenakker G, Van Damme J, Hedrick JA, Lundell D, Lira SA, Hipkin RW. | 01/21/2010 |