| [Zinc finger protein-36 deficiency inhibits osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells and preosteoblasts by activating the ERK/MAPK pathway]. | [Zinc finger protein-36 deficiency inhibits osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells and preosteoblasts by activating the ERK/MAPK pathway].
Rong S, Li H, Wei Y, Feng Z, Gan L, Deng Z, Zhao L., Free PMC Article | 05/9/2024 |
| LncRNA AA465934 Improves Podocyte Injury by Promoting Tristetraprolin-Mediated HMGB1 DownRegulation in Diabetic Nephropathy. | LncRNA AA465934 Improves Podocyte Injury by Promoting Tristetraprolin-Mediated HMGB1 DownRegulation in Diabetic Nephropathy.
Yang N, Zhang Y, Ren P, Zhao L, Zheng D, Fu L, Jin J., | 04/12/2024 |
| Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models. | Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models.
Tanaka-Yano M, Zong L, Park B, Yanai H, Tekin-Turhan F, Blackshear PJ, Beerman I., Free PMC Article | 02/7/2024 |
| Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins. | Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins.
Sunshine HL, Cicchetto AC, Kaczor-Urbanowicz KE, Ma F, Pi D, Symons C, Turner M, Shukla V, Christofk HR, Vallim TA, Iruela-Arispe ML., Free PMC Article | 02/5/2024 |
| Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid-derived suppressor cells. | Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid-derived suppressor cells.
Zhang L, Kwack KH, Thiyagarajan R, Mullaney KK, Lamb NA, Bard JE, Sohn J, Seldeen KL, Arao Y, Blackshear PJ, Abrams SI, Troen BR, Kirkwood KL., | 12/5/2023 |
| Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation. | Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.
Chen Q, Liu L, Ni S., Free PMC Article | 02/14/2023 |
| The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses. | The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses.
Cook ME, Bradstreet TR, Webber AM, Kim J, Santeford A, Harris KM, Murphy MK, Tran J, Abdalla NM, Schwarzkopf EA, Greco SC, Halabi CM, Apte RS, Blackshear PJ, Edelson BT., Free PMC Article | 10/29/2022 |
| Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin. | Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin.
Hikichi Y, Motomura Y, Takeuchi O, Moro K., Free PMC Article | 01/1/2022 |
| Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. | Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
Dolicka D, Sobolewski C, Gjorgjieva M, Correia de Sousa M, Berthou F, De Vito C, Colin DJ, Bejuy O, Fournier M, Maeder C, Blackshear PJ, Rubbia-Brandt L, Foti M., Free PMC Article | 12/25/2021 |
| Cataloguing the phosphorylation sites of tristetraprolin (TTP): Functional implications for inflammatory diseases. | Cataloguing the phosphorylation sites of tristetraprolin (TTP): Functional implications for inflammatory diseases.
Rezcallah MC, Al-Mazi T, Ammit AJ. | 12/11/2021 |
| The mRNA-destabilizing protein Tristetraprolin targets ""meiosis arrester"" Nppc mRNA in mammalian preovulatory follicles. | The mRNA-destabilizing protein Tristetraprolin targets "meiosis arrester" Nppc mRNA in mammalian preovulatory follicles.
Xi G, An L, Wang W, Hao J, Yang Q, Ma L, Lu J, Wang Y, Wang W, Zhao W, Liu J, Yang M, Wang X, Zhang Z, Zhang C, Chu M, Yue Y, Yao F, Zhang M, Tian J., Free PMC Article | 12/4/2021 |
| ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. | ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway.
Cao Y, Huang W, Wu F, Shang J, Ping F, Wang W, Li Y, Zhao X, Zhang X., Free PMC Article | 09/25/2021 |
| RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. | RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Zhang Z, Guo M, Li Y, Shen M, Kong D, Shao J, Ding H, Tan S, Chen A, Zhang F, Zheng S., Free PMC Article | 07/31/2021 |
| Deficiency of Tristetraprolin Triggers Hyperthermia through Enhancing Hypothalamic Inflammation. | Deficiency of Tristetraprolin Triggers Hyperthermia through Enhancing Hypothalamic Inflammation.
Jeong DY, Song N, Yang HR, Tu TH, Park BS, Kang H, Park JW, Lee BJ, Yang S, Kim JG., Free PMC Article | 06/12/2021 |
| Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice. | Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.
Saaoud F, Wang J, Iwanowycz S, Wang Y, Altomare D, Shao Y, Liu J, Blackshear PJ, Lessner SM, Murphy EA, Wang H, Yang X, Fan D., Free PMC Article | 05/29/2021 |
| Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice. | Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice.
Choudhary I, Vo T, Bathula CS, Lamichhane R, Lewis BW, Looper J, Jeyaseelan S, Blackshear PJ, Saini Y, Patial S., Free PMC Article | 05/8/2021 |
| Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice. | Tristetraprolin Regulates T(H)17 Cell Function and Ameliorates DSS-Induced Colitis in Mice.
Peng H, Ning H, Wang Q, Lai J, Wei L, Stumpo DJ, Blackshear PJ, Fu M, Hou R, Hoft DF, Liu J., Free PMC Article | 04/24/2021 |
| RNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease. | RNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease.
Guo J, Lei M, Cheng F, Liu Y, Zhou M, Zheng W, Zhou Y, Gong R, Liu Z., Free PMC Article | 03/20/2021 |
| Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages. | Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages.
Ariana A, Alturki NA, Hajjar S, Stumpo DJ, Tiedje C, Alnemri ES, Gaestel M, Blackshear PJ, Sad S., Free PMC Article | 01/2/2021 |
| Tristetraprolin targets Nos2 expression in the colonic epithelium. | Tristetraprolin targets Nos2 expression in the colonic epithelium.
Eshelman MA, Matthews SM, Schleicher EM, Fleeman RM, Kawasawa YI, Stumpo DJ, Blackshear PJ, Koltun WA, Ishmael FT, Yochum GS., Free PMC Article | 11/21/2020 |
| Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis. | Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.
Joe Y, Chen Y, Park J, Kim HJ, Rah SY, Ryu J, Cho GJ, Choi HS, Ryter SW, Park JW, Kim UH, Chung HT. | 10/24/2020 |
| Results show that TTP lacking its C-terminal CNOT1 binding domain can still act to promote target mRNA instability in vitro and in vivo. This process is conserved throughout the eukarya. | Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo.
Lai WS, Stumpo DJ, Wells ML, Gruzdev A, Hicks SN, Nicholson CO, Yang Z, Faccio R, Webster MW, Passmore LA, Blackshear PJ., Free PMC Article | 02/8/2020 |
| Data confirm the important role of innate immune cells in regulating hepatic insulin sensitivity and lipid metabolism, challenge-prevailing models in which M1 inflammatory responses predict insulin resistance, and indicate that myeloid-expressed Zfp36 modulates the response to insulin in mice. | Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice.
Caracciolo V, Young J, Gonzales D, Ni Y, Flowers SJ, Summer R, Waldman SA, Kim JK, Jung DY, Noh HL, Kim T, Blackshear PJ, O'Connell D, Bauer RC, Kallen CB., Free PMC Article | 07/27/2019 |
| These findings uncover a critical role for ZFP36 RBPs in restraining T cell expansion and effector functions. | ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity.
Moore MJ, Blachere NE, Fak JJ, Park CY, Sawicka K, Parveen S, Zucker-Scharff I, Moltedo B, Rudensky AY, Darnell RB., Free PMC Article | 05/4/2019 |
| we developed a knock-in mouse with a cysteine-to-arginine mutation within the first zinc finger. Homozygous knock-in mice developed a severe inflammatory syndrome that was essentially identical to that of complete TTP deficiency | A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency.
Lai WS, Stumpo DJ, Qiu L, Faccio R, Blackshear PJ., Free PMC Article | 03/9/2019 |