| Oligodendrocyte-derived laminin-gamma1 regulates the blood-brain barrier and CNS myelination in mice. | Oligodendrocyte-derived laminin-γ1 regulates the blood-brain barrier and CNS myelination in mice.
Kang M, Yao Y., Free PMC Article | 06/13/2024 |
| Laminin is the ECM niche for trophoblast stem cells. | Laminin is the ECM niche for trophoblast stem cells.
Kiyozumi D, Nakano I, Sato-Nishiuchi R, Tanaka S, Sekiguchi K., Free PMC Article | 03/13/2021 |
| The Adult Murine Intestine is Dependent on Constitutive Laminin-gamma1 Synthesis. | The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis.
Fields B, DeLaForest A, Zogg M, May J, Hagen C, Komnick K, Wieser J, Lundberg A, Weiler H, Battle MA, Carlson KS., Free PMC Article | 11/21/2020 |
| netrin-4 disrupts laminin networks and basement membranes through high-affinity binding to the laminin gamma-1 chain. | Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.
Reuten R, Patel TR, McDougall M, Rama N, Nikodemus D, Gibert B, Delcros JG, Prein C, Meier M, Metzger S, Zhou Z, Kaltenberg J, McKee KK, Bald T, Tüting T, Zigrino P, Djonov V, Bloch W, Clausen-Schaumann H, Poschl E, Yurchenco PD, Ehrbar M, Mehlen P, Stetefeld J, Koch M., Free PMC Article | 09/8/2018 |
| epidermal laminin-511 is also a key regulator for later hair development and hair shaft differentiation. | Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.
Fleger-Weckmann A, Üstün Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. | 02/10/2018 |
| Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1, GPBP, Lamc1, peroxidasin) during uterine reprogramming. | Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming.
Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG., Free PMC Article | 01/6/2018 |
| Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination. | Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination.
Ghidinelli M, Poitelon Y, Shin YK, Ameroso D, Williamson C, Ferri C, Pellegatta M, Espino K, Mogha A, Monk K, Podini P, Taveggia C, Nave KA, Wrabetz L, Park HT, Feltri ML., Free PMC Article | 10/7/2017 |
| Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes. | Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes.
Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A., Free PMC Article | 04/2/2016 |
| The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation. | Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution.
Patel TR, Bernards C, Meier M, McEleney K, Winzor DJ, Koch M, Stetefeld J. | 10/18/2014 |
| These findings document a pathogenic potential of antibodies targeting the laminin gamma1 N-terminus. | Ex vivo pathogenicity of anti-laminin γ1 autoantibodies.
Florea F, Bernards C, Caproni M, Kleindienst J, Hashimoto T, Koch M, Sitaru C. | 09/20/2014 |
| LNgamma1-knockout mice present with intracerebral hemorrhage in adulthood. | Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.
Chen ZL, Yao Y, Norris EH, Kruyer A, Jno-Charles O, Akhmerov A, Strickland S., Free PMC Article | 09/28/2013 |
| Laminins integrate scaffold-forming and cell-adhesion activities to assemble an endoneurial basement membrane. | Schwann cell myelination requires integration of laminin activities.
McKee KK, Yang DH, Patel R, Chen ZL, Strickland S, Takagi J, Sekiguchi K, Yurchenco PD., Free PMC Article | 04/27/2013 |
| STI1 and Ln-gamma1 promote robust axonogenesis in wild-type neurons, whereas no effect is observed in neurons from PrPC-null mice. | Laminin-γ1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons.
Santos TG, Beraldo FH, Hajj GN, Lopes MH, Roffe M, Lupinacci FC, Ostapchenko VG, Prado VF, Prado MA, Martins VR. | 03/9/2013 |
| requirement of gamma1 laminins for assembly of the renal collecting duct system basement membrane, in which immobilized ligands act as solid-phase agonists to promote branching morphogenesis, growth and water transport functions | Renal collecting system growth and function depend upon embryonic γ1 laminin expression.
Yang DH, McKee KK, Chen ZL, Mernaugh G, Strickland S, Zent R, Yurchenco PD., Free PMC Article | 12/3/2011 |
| Data show that expression of either mGluR1 or mGluR5 in HEK293 cells reconstituted the signaling pathways mediated by PrP(C)-Ln gamma1 peptide interaction. | Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.
Beraldo FH, Arantes CP, Santos TG, Machado CF, Roffe M, Hajj GN, Lee KS, Magalhães AC, Caetano FA, Mancini GL, Lopes MH, Américo TA, Magdesian MH, Ferguson SS, Linden R, Prado MA, Martins VR. | 03/12/2011 |
| Laminin beta(1) and gamma(1) N-terminal domains share the galactose-binding domain-like fold. | Computational modeling of laminin N-terminal domains using sparse distance constraints from disulfide bonds and chemical cross-linking.
Kalkhof S, Haehn S, Paulsson M, Smyth N, Meiler J, Sinz A., Free PMC Article | 02/26/2011 |
| Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain. | Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
Mokkapati S, Fleger-Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, Smyth N, Nischt R., Free PMC Article | 02/26/2011 |
| laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts | Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.
Rooney JE, Gurpur PB, Burkin DJ., Free PMC Article | 01/21/2010 |
| The role of the laminin gamma1 chain for cardiac muscle differentiation and function using cardiomyocytes derived from embryonic stem cells deficient in the LAMC1 gene, was investigated. | Lack of laminin gamma1 in embryonic stem cell-derived cardiomyocytes causes inhomogeneous electrical spreading despite intact differentiation and function.
Malan D, Reppel M, Dobrowolski R, Roell W, Smyth N, Hescheler J, Paulsson M, Bloch W, Fleischmann BK. | 01/21/2010 |
| Laminins are required for Schwann cell to form a bipolar shape as well as for process extension. | Laminin is required for Schwann cell morphogenesis.
Yu WM, Chen ZL, North AJ, Strickland S., Free PMC Article | 01/21/2010 |
| laminin regulates neurite growth and neuronal migration via integrin signaling through the AKT/GSK-3beta pathway | Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration.
Chen ZL, Haegeli V, Yu H, Strickland S., Free PMC Article | 01/21/2010 |
| Combinatorial selection based on phage display technology revealed a previously unrecognized complex between the soluble protein netrin-4 and laminin gamma1 subunit that activates an alpha6beta1 integrin-mediated signaling pathway in neural stem cells | Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells.
Staquicini FI, Dias-Neto E, Li J, Snyder EY, Sidman RL, Pasqualini R, Arap W., Free PMC Article | 01/21/2010 |
| netrin-4 is a component of basement membranes and is integrated into the laminin polymer via interactions with the laminin gamma1 andgamma3 short arms | Binding of netrin-4 to laminin short arms regulates basement membrane assembly.
Schneiders FI, Maertens B, Böse K, Li Y, Brunken WJ, Paulsson M, Smyth N, Koch M. | 01/21/2010 |
| structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5) | Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface.
Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. | 01/21/2010 |
| Mice with reduced expression of laminin gamma1 in Schwann cells also exhibit a reduction in laminin alpha2 and beta1 and exhibit motor defects which lead to hind leg paralysis and tremor. | Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve.
Chen ZL, Strickland S., Free PMC Article | 01/21/2010 |