| Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells. | Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
Henry S, Kokity L, Pirity MK., Free PMC Article | 02/10/2023 |
| The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease. | The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease.
Riegl SD, Starnes C, Jima DD, Baptissart M, Diehl AM, Belcher SM, Cowley M., Free PMC Article | 02/4/2023 |
| Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome. | Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome.
Baptissart M, Bradish CM, Jones BS, Walsh E, Tehrani J, Marrero-Colon V, Mehta S, Jima DD, Oh SH, Diehl AM, Fougeray T, Guillou H, Cowley M., Free PMC Article | 10/1/2022 |
| Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta. | Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta.
Starks RR, Abu Alhasan R, Kaur H, Pennington KA, Schulz LC, Tuteja G., Free PMC Article | 03/20/2021 |
| PLAGL1 may regulate hypothalamic hypocretin transcription. | Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription.
Tanaka S, Honda Y, Takaku S, Koike T, Oe S, Hirahara Y, Yoshida T, Takizawa N, Takamori Y, Kurokawa K, Kodama T, Yamada H., Free PMC Article | 08/3/2019 |
| Zac1/GPR39 system promotes the formation of type II muscle fibers by phosphorylation of CaMK-II. Cells lacking Zac1/GPR39 system tend to remain stemness and form type I muscle fibers after induced differentiation. | Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
Yang Q, Li Y, Zhang X, Chen D. | 05/26/2018 |
| Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition. | Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network.
Varrault A, Dantec C, Le Digarcher A, Chotard L, Bilanges B, Parrinello H, Dubois E, Rialle S, Severac D, Bouschet T, Journot L., Free PMC Article | 11/4/2017 |
| expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors. | Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming.
Rraklli V, Södersten E, Nyman U, Hagey DW, Holmberg J. | 12/17/2016 |
| Transcription factor MEF2 and Zac1 mediate MIF-induced GLUT4 expression through CD74-dependent AMPK activation in cardiomyocytes | Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
Liang Y, Yuan W, Zhu W, Zhu J, Lin Q, Zou X, Deng C, Fu Y, Zheng X, Yang M, Wu S, Yu X, Shan Z. | 02/27/2016 |
| we show that the maternally imprinted gene Zac1 is a critical regulator of neocortical development | Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1.
Adnani L, Langevin LM, Gautier E, Dixit R, Parsons K, Li S, Kaushik G, Wilkinson G, Wilson R, Childs S, Nguyen MD, Journot L, Dehay C, Schuurmans C., Free PMC Article | 01/2/2016 |
| Zac1 interacts with two cis-regulatory elements in the Tcf4 gene locus. | Zac1 regulates cell cycle arrest in neuronal progenitors via Tcf4.
Schmidt-Edelkraut U, Daniel G, Hoffmann A, Spengler D., Free PMC Article | 04/26/2014 |
| results indicate ZAC is a negative regulator of the acute stimulatory effects of glucose on beta-cells. It provides an explanation for both insulin deficiency in the neonate and the later relapse of diabetes in patients with transient neonatal diabetes mellitus cases | Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells.
Du X, Ounissi-Benkalha H, Loder MK, Rutter GA, Polychronakos C., Free PMC Article | 05/4/2013 |
| Hymai and Plagl1it RNAs both have potentially high affinity for Trithorax chromatin regulators. | Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin.
Iglesias-Platas I, Martin-Trujillo A, Cirillo D, Court F, Guillaumet-Adkins A, Camprubi C, Bourc'his D, Hata K, Feil R, Tartaglia G, Arnaud P, Monk D., Free PMC Article | 12/22/2012 |
| identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 target gene in beta cells | Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1.
Hoffmann A, Spengler D., Free PMC Article | 09/8/2012 |
| Zac1 inhibits nuclear factor Kappa B activity by interacting with the C-terminus of the p65 subunit, which suppresses the phosphorylation of p65 at Ser468 and Ser536 residues | Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis.
Shu G, Tang Y, Zhou Y, Wang C, Song JG., Free PMC Article | 03/10/2012 |
| the different expression pattern of Zac1 in mice from human may explain the much milder phenotype in the mouse model of ZAC double dose | Differential expression pattern of ZAC in developing mouse and human pancreas.
Du X, Rousseau M, Ounissi-Benkalha H, Marchand L, Jetha A, Paraskevas S, Goodyer C, Polychronakos C. | 11/5/2011 |
| The Zac1 is a critical regulator of normal cerebellar development, adding a new transcriptional regulator to the growing list of factors involved in generating neuronal diversity in the developing cerebellum. | Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum.
Chung SH, Marzban H, Aldinger K, Dixit R, Millen K, Schuurmans C, Hawkes R., Free PMC Article | 09/17/2011 |
| this study describes for the first time a transcriptional regulation of Zac1b, induced by synthetic dsRNA and RNA viruses | Viral induction of Zac1b through TLR3- and IRF3-dependent pathways.
Warzée B, Mesnil C, Hober D, Caloone D, Pirottin D, Garigliany MM, Desmecht D, Drion PV, Journot L, Lekeux P, Bureau F, Desmet CJ. | 01/8/2011 |
| Plagl1/Zac1 gene is imprinted, with preferential expression from the paternal allele, and is one of a network of imprinted genes involved in the control of embryonic growth. | Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth.
Varrault A, Gueydan C, Delalbre A, Bellmann A, Houssami S, Aknin C, Severac D, Chotard L, Kahli M, Le Digarcher A, Pavlidis P, Journot L. | 12/8/2010 |
| ZAC1 is a novel and previously unknown regulator of cardiomyocyte Glut4 expression and glucose uptake; MEF2 is a regulator of ZAC1 expression in response to induction of hypertrophy | Regulation of cardiomyocyte Glut4 expression by ZAC1.
Czubryt MP, Lamoureux L, Ramjiawan A, Abrenica B, Jangamreddy J, Swan K., Free PMC Article | 06/28/2010 |
| Zac1 plays an essential role in the cardiac gene regulatory network. Data provide a potential link between Zac1 in cardiogenesis and congenital heart disease manifestations associated with genetic or epigenetic defects in an imprinted gene network. | Zac1 is an essential transcription factor for cardiac morphogenesis.
Yuasa S, Onizuka T, Shimoji K, Ohno Y, Kageyama T, Yoon SH, Egashira T, Seki T, Hashimoto H, Nishiyama T, Kaneda R, Murata M, Hattori F, Makino S, Sano M, Ogawa S, Prall OW, Harvey RP, Fukuda K. | 05/3/2010 |
| Zac1 mRNA preferentially accumulates in close proximity to nucleoli within the cell nucleus. | Spatial link between nucleoli and expression of the Zac1 gene.
Royo F, Paz N, Espinosa L, McQueen PG, Vellón L, Parada LA., Free PMC Article | 04/12/2010 |
| The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte. | ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.
Lanaspa MA, Andres-Hernando A, Rivard CJ, Dai Y, Li N, Berl T., Free PMC Article | 01/21/2010 |
| show here that Zac1 has an essential role in cell number control during retinal development, akin to its role in tumor surveillance in mature tissues. | Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.
Ma L, Cantrup R, Varrault A, Colak D, Klenin N, Götz M, McFarlane S, Journot L, Schuurmans C., Free PMC Article | 01/21/2010 |
| loss of methylation within this region is seen in some patients with transient neonatal diabetes mellitus, and hypermethylation of this region is found in ovarian cancer and is associated with changes in expression of PLAGL1. | Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis.
Arima T, Wake N. | 01/21/2010 |