| 14-3-3gamma haploinsufficiency leads to altered dopamine pathway and Parkinson's disease-like motor incoordination in mice. | 14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson's disease-like motor incoordination in mice.
Cho E, Park J, Hwang EM, Kim HW, Park JY., Free PMC Article | 01/14/2023 |
| miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3gamma in early stage of 5xFAD mouse model of Alzheimer's disease. | miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease.
Park H, Lee YB, Chang KA., Free PMC Article | 04/30/2022 |
| 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban. | 14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban.
Menzel J, Kownatzki-Danger D, Tokar S, Ballone A, Unthan-Fechner K, Kilisch M, Lenz C, Urlaub H, Mori M, Ottmann C, Shattock MJ, Lehnart SE, Schwappach B. | 10/30/2021 |
| Sec23ip is involved in cholesterol trafficking to supply cholesterol for acute steroidogenesis through its interactions with 14-3-3gamma. | Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells.
Aghazadeh Y, Venugopal S, Martinez-Arguelles DB, Boisvert A, Blonder J, Papadopoulos V., Free PMC Article | 07/18/2020 |
| Increased 14-3-3 gamma protein isoform expressions is associated with parasitic eosinophilic meningitis. | Increased 14-3-3β and γ protein isoform expressions in parasitic eosinophilic meningitis caused by Angiostrongylus cantonensis infection in mice.
Tsai HC, Chen YH, Yen CM, Lee SS, Chen YS., Free PMC Article | 12/7/2019 |
| 14-3-3gamma promotes surface expression of Best1 channel in astrocytes through direct interaction. | Direct interaction with 14-3-3γ promotes surface expression of Best1 channel in astrocyte.
Oh SJ, Woo J, Lee YS, Cho M, Kim E, Cho NC, Park JY, Pae AN, Justin Lee C, Hwang EM., Free PMC Article | 07/28/2018 |
| This study found that in utero 14-3-3gamma-deficiency resulted in delays in neuronal migration as well as morphological defects. | Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex.
Wachi T, Cornell B, Marshall C, Zhukarev V, Baas PW, Toyo-oka K. | 01/14/2017 |
| Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two. | Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3γ, and Dok-7 proteins and phosphorylates the latter two.
Herrmann D, Straubinger M, Hashemolhosseini S., Free PMC Article | 12/5/2015 |
| These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma binding. | Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death.
Cho CH, Kim E, Lee YS, Yarishkin O, Yoo JC, Park JY, Hong SG, Hwang EM., Free PMC Article | 04/18/2015 |
| Ser(58) phosphorylation and Lys(49) acetylation of 14-3-3gamm occur in a coordinated time-dependent manner to regulate 14-3-3gamma homodimerization. | Protein modifications regulate the role of 14-3-3γ adaptor protein in cAMP-induced steroidogenesis in MA-10 Leydig cells.
Aghazadeh Y, Ye X, Blonder J, Papadopoulos V., Free PMC Article | 02/7/2015 |
| hypoxia can activate p53 through inactivation of MDMX by the ATR-Chk1-MDMX-14-3-3gamma pathway. | Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.
Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl GM, Lu H., Free PMC Article | 08/25/2012 |
| Data show that binding motifs of 14-3-3gamma were identified in components of the transduceosome, including STAR. | Hormone-induced 14-3-3γ adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells.
Aghazadeh Y, Rone MB, Blonder J, Ye X, Veenstra TD, Hales DB, Culty M, Papadopoulos V., Free PMC Article | 08/4/2012 |
| overexpression of 14-3-3gamma led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins. | Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.
Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG., Free PMC Article | 06/25/2011 |
| a new role for 14-3-3gamma in protecting p21 from MDMX-mediated proteasomal turnover, which may partially account for DNA damage-induced elevation of p21 levels independent of p53. | 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.
Lee JH, Lu H., Free PMC Article | 04/16/2011 |
| Studies establish 14-3-3gamma as an oncogene and implicate MAPK and PI3K signaling as important for 14-3-3gamma induced transformation. | 14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling.
Radhakrishnan VM, Martinez JD., Free PMC Article | 10/30/2010 |
| Data suggest that 14-3-3 regulates LRRK2 and that disruption of the interaction of LRRK2 with 14-3-3 may be linked to Parkinson's disease. | 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR., Free PMC Article | 10/23/2010 |
| Data suggest that neuroglobin contributes to neuronal defensive machinery against oxidative injuries by regulating 14-3-3gamma expression. | Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma.
Ye SQ, Zhou XY, Lai XJ, Zheng L, Chen XQ., Free PMC Article | 01/21/2010 |
| the binding of 14-3-3gamma to Raf indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture. | 14-3-3gamma is upregulated by in vitro ischemia and binds to protein kinase Raf in primary cultures of astrocytes.
Chen XQ, Chen JG, Zhang Y, Hsiao WW, Yu AC. | 01/21/2010 |
| Nuclear poly-ADP-ribosylation of 14-3-3gamma was completely inhibited by the dose of the PARP-1 inhibitor 5-iodo-6-amino-1,2-benzopyrone that produced profound memory disturbances in maze learning tests | A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma.
Satchell MA, Zhang X, Kochanek PM, Dixon CE, Jenkins LW, Melick J, Szabó C, Clark RS. | 01/21/2010 |
| The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes | The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes.
Chen XQ, Yu AC. | 01/21/2010 |