| Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon. | Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon.
King JW, Bennett ASW, Wood HM, Baker CC, Alsaadi H, Topley M, Vanner SA, Reed DE, Lomax AE. | 06/28/2024 |
| A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens. | A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.
Zhou Y, Bennett TM, Ruzycki PA, Guo Z, Cao YQ, Shahidullah M, Delamere NA, Shiels A., Free PMC Article | 02/16/2024 |
| TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain. | TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain.
Aloi VD, Pinto SJPC, Van Bree R, Luyten K, Voets T, Vriens J., Free PMC Article | 08/28/2023 |
| Vasoprotective effects of NOX4 are mediated via polymerase and transient receptor potential melastatin 2 cation channels in endothelial cells. | Vasoprotective effects of NOX4 are mediated via polymerase and transient receptor potential melastatin 2 cation channels in endothelial cells.
Alves-Lopes R, Lacchini S, Neves KB, Harvey A, Montezano AC, Touyz RM., Free PMC Article | 08/9/2023 |
| Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Zhao C, MacKinnon R. | 01/14/2023 |
| TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms. | TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms.
Behrendt M. | 07/16/2022 |
| TRPM3 Is Expressed in Afferent Bladder Neurons and Is Upregulated during Bladder Inflammation. | TRPM3 Is Expressed in Afferent Bladder Neurons and Is Upregulated during Bladder Inflammation.
Vanneste M, Mulier M, Nogueira Freitas AC, Van Ranst N, Kerstens A, Voets T, Everaerts W., Free PMC Article | 02/5/2022 |
| The Impact of Steroid Activation of TRPM3 on Spontaneous Activity in the Developing Retina. | The Impact of Steroid Activation of TRPM3 on Spontaneous Activity in the Developing Retina.
Webster CM, Tworig J, Caval-Holme F, Morgans CW, Feller MB., Free PMC Article | 07/31/2021 |
| Mutation of the TRPM3 cation channel underlies progressive cataract development and lens calcification associated with pro-fibrotic and immune cell responses. | Mutation of the TRPM3 cation channel underlies progressive cataract development and lens calcification associated with pro-fibrotic and immune cell responses.
Zhou Y, Bennett TM, Shiels A., Free PMC Article | 06/26/2021 |
| TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve Injury. | TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve Injury.
Su S, Yudin Y, Kim N, Tao YX, Rohacs T., Free PMC Article | 06/12/2021 |
| Control of Insulin Release by Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels. | Control of Insulin Release by Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels.
Becker A, Mannebach S, Mathar I, Weissgerber P, Freichel M, Loodin AP, Fecher-Trost C, Belkacemi A, Beck A, Philipp SE. | 05/29/2021 |
| The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators. | The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators.
Kelemen B, Pinto S, Kim N, Lisztes E, Hanyicska M, Vladár A, Oláh A, Pénzes Z, Shu B, Vriens J, Bíró T, Rohács T, Voets T, Tóth BI., Free PMC Article | 04/17/2021 |
| ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. | ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.
Xie MX, Cao XY, Zeng WA, Lai RC, Guo L, Wang JC, Xiao YB, Zhang X, Chen D, Liu XG, Zhang XL., Free PMC Article | 03/20/2021 |
| Upregulation of TRPM3 in nociceptors innervating inflamed tissue. | Upregulation of TRPM3 in nociceptors innervating inflamed tissue.
Mulier M, Van Ranst N, Corthout N, Munck S, Vanden Berghe P, Vriens J, Voets T, Moilanen L., Free PMC Article | 02/27/2021 |
| TRPM3 is implicated in the regulation of the tone of resistance arteries. | Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries.
Alonso-Carbajo L, Alpizar YA, Startek JB, López-López JR, Pérez-García MT, Talavera K. | 06/27/2020 |
| TRPM3gamma variants have low channel activity compared to TRPM3alpha. | Identification and classification of a new TRPM3 variant (γ subtype).
Uchida K, Fukuta N, Yamazaki J, Tominaga M., Free PMC Article | 12/21/2019 |
| Knocking out TRPM3 did not change the level of TRPP2 protein in the cilia of primary renal epithelial cells, so it is unlikely that the absence of functional ciliary channels results from a failure of trafficking. | The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
Kleene SJ, Siroky BJ, Landero-Figueroa JA, Dixon BP, Pachciarz NW, Lu L, Kleene NK., Free PMC Article | 12/14/2019 |
| Site-directed mutagenesis studies and patch clamp experiments led to the identification of four residues in S4 (W982, R985, D988 and G991) as crucial determinants of the properties of the alternative ion permeation pathway involved in the formation of the non-canonical pore in TRPM3. | Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel.
Held K, Gruss F, Aloi VD, Janssens A, Ulens C, Voets T, Vriens J., Free PMC Article | 10/26/2019 |
| findings indicate that the initiation of the acute heat-evoked pain response in sensory nerve endings relies on three functionally redundant TRP channels, representing a fault-tolerant mechanism to avoid burn injury | A TRP channel trio mediates acute noxious heat sensing.
Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T. | 08/18/2018 |
| Primary cilia are required for the maximal osmotic response in renal epithelial cells and TRPM3 is involved in this osmoregulatory mechanism. | Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3.
Siroky BJ, Kleene NK, Kleene SJ, Varnell CD Jr, Comer RG, Liu J, Lu L, Pachciarz NW, Bissler JJ, Dixon BP., Free PMC Article | 07/15/2017 |
| TRPM3 activation in sensory nerve endings can contribute to neurogenic inflammation. | Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck JC, Marchand A, Reeh PW, Chaltin P, Voets T, Vriens J., Free PMC Article | 06/6/2015 |
| transcriptional control of Trpm3/miR-204 is reported. | Gene regulation by PAX6: structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204.
Xie Q, Ung D, Khafizov K, Fiser A, Cvekl A., Free PMC Article | 10/4/2014 |
| data support an indirect role for TRPM3 in pupillary light responses | Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.
Hughes S, Pothecary CA, Jagannath A, Foster RG, Hankins MW, Peirson SN., Free PMC Article | 05/12/2012 |
| These experiments reveal an unanticipated role for TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat. | TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, Benoit M, Xue F, Janssens A, Kerselaers S, Oberwinkler J, Vennekens R, Gudermann T, Nilius B, Voets T. | 07/16/2011 |
| Signal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors. | Signal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors.
Mayer SI, Müller I, Mannebach S, Endo T, Thiel G., Free PMC Article | 06/18/2011 |