| Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice. | Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice.
Fuentes ME, Lu X, Flores NM, Hausmann S, Mazur PK., Free PMC Article | 04/17/2024 |
| Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice. | Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice.
Rowland ME, Jiang Y, Shafiq S, Ghahramani A, Pena-Ortiz MA, Dumeaux V, Bérubé NG., Free PMC Article | 11/27/2023 |
| A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects. | A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects.
Tillotson R, Yan K, Ruston J, DeYoung T, Córdova A, Turcotte-Cardin V, Yee Y, Taylor C, Visuvanathan S, Babbs C, Ivakine EA, Sled JG, Nieman BJ, Picketts DJ, Justice MJ., Free PMC Article | 07/31/2023 |
| Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus. | Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus.
Floyd W, Pierpoint M, Su C, Patel R, Luo L, Deland K, Wisdom AJ, Zhu D, Ma Y, DeWitt SB, Williams NT, Lazarides AL, Somarelli JA, Corcoran DL, Eward WC, Cardona DM, Kirsch DG., Free PMC Article | 07/7/2023 |
| TERRA regulates DNA G-quadruplex formation and ATRX recruitment to chromatin. | TERRA regulates DNA G-quadruplex formation and ATRX recruitment to chromatin.
Tsai RX, Fang KC, Yang PC, Hsieh YH, Chiang IT, Chen Y, Lee HG, Lee JT, Chu HC., Free PMC Article | 12/24/2022 |
| ATRX histone binding and helicase activities have distinct roles in neuronal differentiation. | ATRX histone binding and helicase activities have distinct roles in neuronal differentiation.
Bieluszewska A, Wulfridge P, Doherty J, Ren W, Sarma K., Free PMC Article | 11/19/2022 |
| ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma. | ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma.
Babikir H, Wang L, Shamardani K, Catalan F, Sudhir S, Aghi MK, Raleigh DR, Phillips JJ, Diaz AA., Free PMC Article | 03/19/2022 |
| Inactivation of ATRX in forebrain excitatory neurons affects hippocampal synaptic plasticity. | Inactivation of ATRX in forebrain excitatory neurons affects hippocampal synaptic plasticity.
Gugustea R, Tamming RJ, Martin-Kenny N, Bérubé NG, Leung LS. | 09/4/2021 |
| Sensory Experience Modulates Atrx-mediated Neuronal Integrity in the Mouse Retina. | Sensory Experience Modulates Atrx-mediated Neuronal Integrity in the Mouse Retina.
Lagali PS, Zhao BYH, Yan K, Baker AN, Coupland SG, Tsilfidis C, Picketts DJ. | 08/21/2021 |
| Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. | Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.
Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG., Free PMC Article | 05/1/2021 |
| Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. | Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function.
Ren W, Medeiros N, Warneford-Thomson R, Wulfridge P, Yan Q, Bian J, Sidoli S, Garcia BA, Skordalakes E, Joyce E, Bonasio R, Sarma K., Free PMC Article | 08/15/2020 |
| ATRX has an effect on telomeric Double strand breaks repair and this role involves both telomere cohesion and a DAXX-dependent pathway. | ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.
Lovejoy CA, Takai K, Huh MS, Picketts DJ, de Lange T., Free PMC Article | 04/25/2020 |
| MeCP2, together with Alpha-thalassemia/mental retardation syndrome X-linked protein (ATRX), accumulates at chromocenters, which are repressive PCH domains. As with MECP2, mutations in ATRX cause ATR-X syndrome which is associated with severe intellectual disability. | ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation.
Marano D, Fioriniello S, Fiorillo F, Gibbons RJ, D'Esposito M, Della Ragione F., Free PMC Article | 03/28/2020 |
| A lncRNA ChRO1 specifically associates with ATRX/DAXX/H3.3 complex at chromocenters to promote H3.3 incorporation and transcriptional induction of satellite repeats, which is essential for chromocenter clustering thus unveiling a mechanism involving a lncRNA that plays a role in large-scale heterochromatin reorganization and cell differentiation. | Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization.
Park J, Lee H, Han N, Kwak S, Lee HT, Kim JH, Kang K, Youn BH, Yang JH, Jeong HJ, Kang JS, Kim SY, Han JW, Youn HD, Cho EJ., Free PMC Article | 06/29/2019 |
| the absence of ATRX increases sensitivity to injury and oncogenic KRAS only in female mice. | The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice.
Young CC, Baker RM, Howlett CJ, Hryciw T, Herman JE, Higgs D, Gibbons R, Crawford H, Brown A, Pin CL., Free PMC Article | 05/4/2019 |
| Rad54/Rad54B deficiency may impact on the DNA integrity of developing mouse gametes. | Rad54/Rad54B deficiency is associated to increased chromosome breakage in mouse spermatocytes.
Russo A, Cordelli E, Salvitti T, Palumbo E, Pacchierotti F. | 02/2/2019 |
| Atrx-dependent gene expression changes in neuroepithelial progenitor cells were accompanied by altered cellular morphology, increased motility, and a shift in differentiation markers toward an astrocytic histiogenic profile. These latter two phenotypes recapitulate two cardinal features of ATRX-mutant gliomas. | Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.
Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang FF, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT., Free PMC Article | 12/22/2018 |
| PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX and DAXX. | PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX.
Delbarre E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug JØ, Bøe SO, Wong LH, Küntziger T, Collas P., Free PMC Article | 03/10/2018 |
| Gene expression changes in the Atrx-null retina indicate defective synaptic structure and neuronal circuitry, suggest excitotoxic mechanisms of neurodegeneration, and demonstrate that common targets of ATRX in the forebrain and retina may contribute to similar neuropathological processes underlying cognitive impairment and visual dysfunction in ATR-X syndrome. | Retinal interneuron survival requires non-cell-autonomous Atrx activity.
Lagali PS, Medina CF, Zhao BY, Yan K, Baker AN, Coupland SG, Tsilfidis C, Wallace VA, Picketts DJ. | 02/3/2018 |
| mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory. | Mosaic expression of Atrx in the mouse central nervous system causes memory deficits.
Tamming RJ, Siu JR, Jiang Y, Prado MA, Beier F, Bérubé NG., Free PMC Article | 12/9/2017 |
| The results suggest that ATRX is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production. | Stalled replication forks within heterochromatin require ATRX for protection.
Huh MS, Ivanochko D, Hashem LE, Curtin M, Delorme M, Goodall E, Yan K, Picketts DJ., Free PMC Article | 11/4/2017 |
| The long noncoding RNA, TERRA can bind both in cis to telomeres and in trans to genic targets; a large network of interacting proteins was defined, including epigenetic factors, telomeric proteins, and the RNA helicase, ATRX. TERRA and ATRX share hundreds of target genes and are functionally antagonistic at these loci: whereas TERRA activates, ATRX represses gene expression. | TERRA RNA Antagonizes ATRX and Protects Telomeres.
Chu HP, Cifuentes-Rojas C, Kesner B, Aeby E, Lee HG, Wei C, Oh HJ, Boukhali M, Haas W, Lee JT., Free PMC Article | 08/5/2017 |
| The changes of ATRX distribution occur and partially correlate with the main stages of zygotic genome activation during mouse early development, butthese changes seem to be determined by other processes of structural and functional rearrangements of blastomere nuclei. | Nuclear distribution of the chromatin-remodeling protein ATRX in mouse early embryogenesis.
Sailau ZK, Bogolyubov DS, Bogolyubova IO. | 01/14/2017 |
| ATRX mutation is associated with increased mutation rate at the single-nucleotide variant (SNV) level. | ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.
Koschmann C, Calinescu AA, Nunez FJ, Mackay A, Fazal-Salom J, Thomas D, Mendez F, Kamran N, Dzaman M, Mulpuri L, Krasinkiewicz J, Doherty R, Lemons R, Brosnan-Cashman JA, Li Y, Roh S, Zhao L, Appelman H, Ferguson D, Gorbunova V, Meeker A, Jones C, Lowenstein PR, Castro MG., Free PMC Article | 12/17/2016 |
| Daxx and Atrx safeguard the genome by silencing repetitive elements when DNA methylation levels are low. | The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation.
He Q, Kim H, Huang R, Lu W, Tang M, Shi F, Yang D, Zhang X, Huang J, Liu D, Songyang Z., Free PMC Article | 06/11/2016 |