| CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining. | CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.
Wang XS, Zhao J, Wu-Baer F, Shao Z, Lee BJ, Cupo OM, Rabadan R, Gautier J, Baer R, Zha S., Free PMC Article | 12/26/2020 |
| essential for early B cell proliferation and development | CtIP is essential for early B cell proliferation and development in mice.
Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S., Free PMC Article | 06/27/2020 |
| CtIP enhances long-range resection by BLM-DNA2-RPA. CtIP interacts with and stimulates the activity of the BLM helicase and upregulates DNA2 activity. | Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP.
Daley JM, Jimenez-Sainz J, Wang W, Miller AS, Xue X, Nguyen KA, Jensen RB, Sung P., Free PMC Article | 06/16/2018 |
| CtIP is not a tumor suppressor, but has oncogenic properties that can promote tumorigenesis, consistent with its ability to facilitate MMEJ-dependent chromosomal instability. | The DNA resection protein CtIP promotes mammary tumorigenesis.
Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R., Free PMC Article | 12/30/2017 |
| we reveal that reprogramming is associated with high levels of DNA end resection, a critical step in homologous recombination. Moreover, the resection factor CtIP is essential for cell reprogramming and establishment of iPSCs, probably to repair reprogramming-induced DNA damage. | CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells.
Gómez-Cabello D, Checa-Rodríguez C, Abad M, Serrano M, Huertas P., Free PMC Article | 11/25/2017 |
| Q418P nsSNP influences the efficiency of CTIP function in HR repair of DNA DSBs | The Influence of the CTIP Polymorphism, Q418P, on Homologous Recombination and Predisposition to Radiation-Induced Tumorigenesis (mainly rAML) in Mice.
Patel A, Anderson J, Kraft D, Finnon R, Finnon P, Scudamore CL, Manning G, Bulman R, Brown N, Bouffler S, O'Neill P, Badie C. | 05/27/2017 |
| Ctip1 couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections. | Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.
Woodworth MB, Greig LC, Liu KX, Ippolito GC, Tucker HO, Macklis JD., Free PMC Article | 02/25/2017 |
| work therefore ascribes novel roles for BRCA1 and CtIP in end-processing and fusion reactions at uncapped telomeres | BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M., Free PMC Article | 03/28/2015 |
| Data indicate that loss of the CtIP-BRCA1 interaction does not detectably affect resection, maintenance of genomic stability or viability. | CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A., Free PMC Article | 08/23/2014 |
| The phospho-dependent BRCA1-CtIP interaction is not essential for HDR-mediated DSB repair or for tumor suppression. | The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
Reczek CR, Szabolcs M, Stark JM, Ludwig T, Baer R., Free PMC Article | 08/3/2013 |
| CtIP contributes to the metabolism of DNA ends during DNA double-strand breaks repair in B lymphocytes. | Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM Jr, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF., Free PMC Article | 04/13/2013 |
| the histone protein H2AX prevents nucleases other than Artemis from processing hairpin-sealed coding ends; in the absence of H2AX, CtIP can efficiently promote the hairpin opening and resection of DNA ends generated by RAG cleavage | H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP., Free PMC Article | 02/26/2011 |
| CtIP binds to switch-region DNA and plays a physiological role in microhomology-mediated end joining in a C-NHEJ-proficient environment. | CtIP promotes microhomology-mediated alternative end joining during class-switch recombination.
Lee-Theilen M, Matthews AJ, Kelly D, Zheng S, Chaudhuri J., Free PMC Article | 02/26/2011 |
| CtIP-mediated alt-NHEJ has a primary role in translocation formation. | An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway.
Zhang Y, Jasin M., Free PMC Article | 02/26/2011 |
| CtIP counteracts Rb-mediated G(1) restraint. | Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency.
Chen PL, Liu F, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, Lee WH., Free PMC Article | 01/21/2010 |
| CtiP activates its own and cyclin D promoters via the E2F/RB pathway during G1/S progression. | CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.
Liu F, Lee WH., Free PMC Article | 01/21/2010 |
| Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain | Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.
Darakhshan F, Badie C, Moody J, Coster M, Finnon R, Finnon P, Edwards AA, Szluinska M, Skidmore CJ, Yoshida K, Ullrich R, Cox R, Bouffler SD. | 01/21/2010 |