| Primer on FGF3. | Primer on FGF3.
Hutchings C, Sela-Donenfeld D. | 09/21/2024 |
| Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER(+) Metastatic Breast Cancer. | Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER(+) Metastatic Breast Cancer.
Mao P, Cohen O, Kowalski KJ, Kusiel JG, Buendia-Buendia JE, Cuoco MS, Exman P, Wander SA, Waks AG, Nayar U, Chung J, Freeman S, Rozenblatt-Rosen O, Miller VA, Piccioni F, Root DE, Regev A, Winer EP, Lin NU, Wagle N. | 11/27/2021 |
| eight cases of LAMM syndrome with three novel FGF3 mutations | Three New Mutations and Mild, Asymmetrical Phenotype in the Highly Distinctive LAMM Syndrome: A Report of Eight Further Cases.
Al Yassin A, D'Arco F, Morín M, Pagarkar W, Harrop-Griffiths K, Shaida A, Fernández E, Cullup T, De-Souza B, Moreno-Pelayo MA, Bitner-Glindzicz M., Free PMC Article | 01/4/2020 |
| Upregulation of int-2 expression can significantly inhibit the invasion and metastasis of BcaCD885 cells | Inhibitory effects of int-2 gene on the invasion and metastasis of oral cancer cells.
Liu LM. | 12/21/2019 |
| Genetic polymorphisms in FGF3, FGF10, and FGF13 genes were associated with temporomandibular disorders in a population with dentofacial deformities | Polymorphisms in FGF3, FGF10, and FGF13 May Contribute to the Presence of Temporomandibular Disorders in Patients Who Required Orthognathic Surgery.
Carpio Horta K, Weiss SG, Miranda K, Sebastiani AM, Costa DJD, Matsumoto MAN, Marañón-Vásquez GA, Vieira AR, Scariot R, Küchler EC. | 11/30/2019 |
| FGFR1 and/or FGF3 gene amplification correlated with a lower pathologic complete response in patients with HER2(+) early breast cancer treated with neoadjuvant anti-HER2 therapy | HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2.
Hanker AB, Garrett JT, Estrada MV, Moore PD, Ericsson PG, Koch JP, Langley E, Singh S, Kim PS, Frampton GM, Sanford E, Owens P, Becker J, Groseclose MR, Castellino S, Joensuu H, Huober J, Brase JC, Majjaj S, Brohée S, Venet D, Brown D, Baselga J, Piccart M, Sotiriou C, Arteaga CL., Free PMC Article | 06/23/2018 |
| fibroblast growth factor receptor 3 missense mutations were identified in 5 cases of thanatophoric dysplasia | Genetically confirmed thanatophoric dysplasia with fibroblast growth factor receptor 3 mutation.
Jung M, Park SH. | 08/12/2017 |
| MCF7 cells over-expressing both WNT1 and FGF3 show a 3.5-fold increase in mammosphere formation; conditioned media from these cells also promotes stem cell activity in untransfected parental MCF7 and T47D cells, as WNT1 and FGF3 are secreted factors. | Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling.
Lamb R, Bonuccelli G, Ozsvári B, Peiris-Pagès M, Fiorillo M, Smith DL, Bevilacqua G, Mazzanti CM, McDonnell LA, Naccarato AG, Chiu M, Wynne L, Martinez-Outschoorn UE, Sotgia F, Lisanti MP., Free PMC Article | 08/20/2016 |
| analysis provided evidence for gene-gene interaction between FGF3 (rs4980700) and PAX9 (rs2073242), increasing risk for isolated oral clefts (p = 0.0003). FGF3 is associated with oral clefts and may interact with PAX9. | Studies of genes involved in craniofacial development and tumorigenesis: FGF3 contributes to isolated oral clefts and may interact with PAX9.
Küchler EC, Sabóia TM, Vieira TC, Lips A, Tannure PN, Deeley K, Reis MF, Ho B, Rey AC, Costa MC, Granjeiro JM, Vieira AR. | 01/23/2016 |
| haplotypes may contribute to the tendon disease process in elite volleyball athletes | BMP4 and FGF3 haplotypes increase the risk of tendinopathy in volleyball athletes.
Salles JI, Amaral MV, Aguiar DP, Lira DA, Quinelato V, Bonato LL, Duarte ME, Vieira AR, Casado PL. | 01/16/2016 |
| FGF3 gene expression is altered in a human breast cancer progression model. | Allelic loss at chromosome 11q13 alters FGF3 gene expression in a human breast cancer progression model.
Roy D, Calaf GM. | 06/27/2015 |
| Higher FGF-23 concentration was associated with LVED mass and with incident atrial fibrillation and may, in part, explain the link between chronic kidney disease and AF. | Fibroblast growth factor-23 and incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS).
Mathew JS, Sachs MC, Katz R, Patton KK, Heckbert SR, Hoofnagle AN, Alonso A, Chonchol M, Deo R, Ix JH, Siscovick DS, Kestenbaum B, de Boer IH., Free PMC Article | 10/4/2014 |
| A de novo 290 kb interstitial duplication of chromosome 11q13.3 including the FGF3 and FGF4 genes. | Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Grillo L, Greco D, Pettinato R, Avola E, Potenza N, Castiglia L, Spalletta A, Amata S, Di Benedetto D, Luciano D, Romano C, Fichera M. | 04/19/2014 |
| tooth agenesis had increased risk of a family history of cancer. tooth agenesis was associated with positive self-reported family history of cancer and variants in FGF3. | Tooth agenesis association with self-reported family history of cancer.
Küchler EC, Lips A, Tannure PN, Ho B, Costa MC, Granjeiro JM, Vieira AR. | 03/16/2013 |
| This study is the first to show a significant association between coronary calcification and elevated serum FGF 23 in children. | Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients.
Srivaths PR, Goldstein SL, Silverstein DM, Krishnamurthy R, Brewer ED. | 09/10/2011 |
| confirm the absence of otodental syndrome in heterozygous FGF3 carriers, but report unilateral microtia in one of them | LAMM syndrome with middle ear dysplasia associated with compound heterozygosity for FGF3 mutations.
Sensi A, Ceruti S, Trevisi P, Gualandi F, Busi M, Donati I, Neri M, Ferlini A, Martini A. | 08/6/2011 |
| Manifestations of recessive FGF3 mutations range from fully penetrant LAMM syndrome to deafness with residual inner ear structures and, by extension, with minimal syndromic features. | Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome.
Riazuddin S, Ahmed ZM, Hegde RS, Khan SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB, Choi BY., Free PMC Article | 04/30/2011 |
| alterations in dosage of the Fgf3 gene cause dental morphological changes | Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.
Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot L., Free PMC Article | 02/22/2010 |
| labyrinth aplasia, microtia, and microdontia (LAMM) syndrome, caused by mutations in FGF3 | A FGF3 mutation associated with differential inner ear malformation, microtia, and microdontia.
Ramsebner R, Ludwig M, Parzefall T, Lucas T, Baumgartner WD, Bodamer O, Cengiz FB, Schoefer C, Tekin M, Frei K. | 02/22/2010 |
| Loss of FGFR3 signaling provides evidence that extracellular signals regulate not simply the proliferation or survival of radial glial cells, but specifically their progression to intermediate progenitor cells during neurogenesis in vivo. | The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis.
Kang W, Wong LC, Shi SH, Hébert JM., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group., Free PMC Article | 06/24/2009 |
| study identified a homozygous missense mutation (c.196G-->T) in FGF3 in 21 affected individuals from a large extended family phenotypically characterized by autosomal recessive syndromic congenital sensorineural deafness, microtia and microdontia | Syndromic congenital sensorineural deafness, microtia and microdontia resulting from a novel homoallelic mutation in fibroblast growth factor 3 (FGF3).
Alsmadi O, Meyer BF, Alkuraya F, Wakil S, Alkayal F, Al-Saud H, Ramzan K, Al-Sayed M., Free PMC Article | 01/21/2010 |
| sequenced the FGF3 gene in 10 unrelated families in which probands had congenital deafness associated with various inner ear anomalies, including Michel aplasia, with or without tooth or external ear anomalies. | Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia.
Tekin M, Oztürkmen Akay H, Fitoz S, Birnbaum S, Cengiz FB, Sennaroğlu L, Incesulu A, Yüksel Konuk EB, Hasanefendioğlu Bayrak A, Sentürk S, Cebeci I, Utine GE, Tunçbilek E, Nance WE, Duman D. | 01/21/2010 |
| Implication of FGF3 and FADD in human craniofacial disease. | SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma.
Gregory-Evans CY, Moosajee M, Hodges MD, Mackay DS, Game L, Vargesson N, Bloch-Zupan A, Rüschendorf F, Santos-Pinto L, Wackens G, Gregory-Evans K. | 01/21/2010 |
| FGF3, FGF7, FGF10, FGF18, and FGFR1 may have roles in nonsyndromic cleft lip and palate | Impaired FGF signaling contributes to cleft lip and palate.
Riley BM, Mansilla MA, Ma J, Daack-Hirsch S, Maher BS, Raffensperger LM, Russo ET, Vieira AR, Dodé C, Mohammadi M, Marazita ML, Murray JC., Free PMC Article | 01/21/2010 |