| Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis. | Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis.
Li H, Li X, Wang Y, Han W, Li H, Zhang Q. | 10/3/2024 |
| Xanthine oxidase mediates chronic stress-induced cerebrovascular dysfunction and cognitive impairment. | Xanthine oxidase mediates chronic stress-induced cerebrovascular dysfunction and cognitive impairment.
Burrage EN, Coblentz T, Prabhu SS, Childers R, Bryner RW, Lewis SE, DeVallance E, Kelley EE, Chantler PD., Free PMC Article | 10/26/2023 |
| Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis. | Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis.
Schmidt HM, DeVallance ER, Lewis SE, Wood KC, Annarapu GK, Carreño M, Hahn SA, Seman M, Maxwell BA, Hileman EA, Xu JZ, Velayutham M, Geldenhuys WJ, Vitturi DA, Shiva S, Kelley EE, Straub AC., Free PMC Article | 05/28/2023 |
| Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy. | Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy.
Ishii T, Kumagae T, Wakui H, Urate S, Tanaka S, Abe E, Suzuki T, Yamaji T, Kinguchi S, Kobayashi R, Haruhara K, Nakamura T, Kobayashi S, Tamura K., Free PMC Article | 12/18/2021 |
| Xanthine oxidoreductase knockout mice with high HPRT activity were not rescued by NAD(+) replenishment. | Xanthine oxidoreductase knockout mice with high HPRT activity were not rescued by NAD(+) replenishment.
Hosoyamada M, Tomioka NH, Ohtsubo T, Ichida K. | 06/12/2021 |
| Xanthine Oxidoreductase-Mediated Superoxide Production Is Not Involved in the Age-Related Pathologies in Sod1-Deficient Mice. | Xanthine Oxidoreductase-Mediated Superoxide Production Is Not Involved in the Age-Related Pathologies in Sod1-Deficient Mice.
Shibuya S, Watanabe K, Ozawa Y, Shimizu T., Free PMC Article | 06/5/2021 |
| Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2. | Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2.
Ristic B, Sivaprakasam S, Narayanan M, Ganapathy V., Free PMC Article | 12/5/2020 |
| The miR-218-xanthine oxidoreductase (XOR) pathway may provide a mechanism and treatment option for nonalcoholic steatohepatitis (NASH). | MiR-218-XOR-ROS Pathway Regulates the Progression of Nonalcoholic Steatohepatitis.
He J, Zhang J, Yu M, Huang Y, Dai Y, Zheng R. | 05/23/2020 |
| After tumor transfer, XO ki mice show strongly increased tumor growth compared to wild type (WT) and XDH ki mice. | Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.
Kusano T, Ehirchiou D, Matsumura T, Chobaz V, Nasi S, Castelblanco M, So A, Lavanchy C, Acha-Orbea H, Nishino T, Okamoto K, Busso N., Free PMC Article | 02/29/2020 |
| Hepatocyte XOR activity is a critical determinant of systemic uric acid homeostasis. Deletion of hepatocyte Xdh is sufficient to prevent systemic hyperuricemia of obesity, and neither prevention nor correction of hyperuricemia improves insulin resistance/dyslipidemia in obesity. | Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.
Harmon DB, Mandler WK, Sipula IJ, Dedousis N, Lewis SE, Eckels JT, Du J, Wang Y, Huckestein BR, Pagano PJ, Cifuentes-Pagano E, Homanics GE, Van't Erve TJ, Stefanovic-Racic M, Jurczak MJ, O'Doherty RM, Kelley EE., Free PMC Article | 12/28/2019 |
| the results identify Xdh gene as one of the major targets of DEHP in newborn ovaries and that the consequent increased level of ROS is possibly responsible for the increment of apoptosis and primordial follicle assembly impairment. | Identification of oxidative stress-related Xdh gene as a di(2-ethylhexyl)phthalate (DEHP) target and the use of melatonin to alleviate the DEHP-induced impairments in newborn mouse ovaries.
Liu JC, Li L, Yan HC, Zhang T, Zhang P, Sun ZY, De Felici M, Reiter RJ, Shen W. | 12/21/2019 |
| The data suggests hyper-activity of xanthine oxidase in Duchenne muscular dystrophy (DMD), identifies xanthine oxidase activity as a contributing factor in eccentric contraction-induced force drop of dystrophin-deficient skeletal muscle and highlights the potential of isoxanthopterin as a noninvasive biomarker in DMD. | Xanthine oxidase is hyper-active in Duchenne muscular dystrophy.
Lindsay A, McCourt PM, Karachunski P, Lowe DA, Ervasti JM., Free PMC Article | 09/28/2019 |
| Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9). | Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD.
Yong T, Li D, Li M, Liang D, Diao X, Deng C, Chen S, Xie Y, Chen D, Zuo D., Free PMC Article | 12/22/2018 |
| Our results demonstrated that Ripk3 was strongly upregulated in murine hearts subjected to IR injury and cardiomyocytes treated with LPS and H2O2..the present study helps to elucidate how necroptosis is mediated by ER stress, via the calcium overload /XO/ROS/mPTP opening axis | Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway.
Zhu P, Hu S, Jin Q, Li D, Tian F, Toan S, Li Y, Zhou H, Chen Y., Free PMC Article | 10/13/2018 |
| eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS. This interplay between XOR and eNOS is proposed to play a significant role in NO homeostasis and blood pressure regulation. | Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.
Peleli M, Zollbrecht C, Montenegro MF, Hezel M, Zhong J, Persson EG, Holmdahl R, Weitzberg E, Lundberg JO, Carlström M. | 01/6/2018 |
| Collectively, these results demonstrate that XO inhibition protects against WD-induced vascular oxidative stress, fibrosis, impaired vasorelaxation, and aortic stiffness in females. Furthermore, excessive oxidative stress resulting from XO activation appears to play a key role in mediating vascular dysfunction induced by chronic exposure to WD consumption in females. | Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice.
Lastra G, Manrique C, Jia G, Aroor AR, Hayden MR, Barron BJ, Niles B, Padilla J, Sowers JR., Free PMC Article | 09/2/2017 |
| NLRP3 inflammasome is decreased and IL-1beta secretion is inhibited in macrophages by hydroxysafflor yellow A and xanthine oxidase | Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages.
Xu X, Guo Y, Zhao J, Wang N, Ding J, Liu Q., Free PMC Article | 08/5/2017 |
| Extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos inhibit xanthine oxidase activity and prevent hyperuricemia. | Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.
Yoon IS, Park DH, Ki SH, Cho SS. | 05/20/2017 |
| Our results suggest that a possible relationship between xanthine oxidase-related reactive oxygen species and TRPV1 may exist during the events preceding eccentric exercise | Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats.
Retamoso LT, Silveira ME Junior, Lima FD, Busanello GL, Bresciani G, Ribeiro LR, Chagas PM, Nogueira CW, Braga AC, Furian AF, Oliveira MS, Fighera MR, Royes LF. | 02/18/2017 |
| inflammasome activation accompanied by an increase in xanthine oxidoreductase activity contributed to fat pad inflammation followed by osteoarthritis progression | Xanthine oxidoreductase activation is implicated in the onset of metabolic arthritis.
Aibibula Z, Ailixiding M, Iwata M, Piao J, Hara Y, Okawa A, Asou Y. | 08/6/2016 |
| XOR is abundant in wounds and participates in normal wound healing through effects on ROS production. | Xanthine Oxidoreductase Function Contributes to Normal Wound Healing.
Madigan MC, McEnaney RM, Shukla AJ, Hong G, Kelley EE, Tarpey MM, Gladwin M, Zuckerbraun BS, Tzeng E., Free PMC Article | 04/2/2016 |
| XOR regulated macrophage IL-1b secretion upon NLRP3 inflammasome activation via xanthine oxidase derived reactive oxygen species. | Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.
Ives A, Nomura J, Martinon F, Roger T, LeRoy D, Miner JN, Simon G, Busso N, So A., Free PMC Article | 03/26/2016 |
| Xanthine oxidase inhibitors are potentially potent therapies for patients with NASH, particularly that associated with hyperuricemia. | The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T. | 09/26/2015 |
| these data support a novel function of the XO-NFAT5 axis in macrophage activation and TLR-induced arthritis | The xanthine oxidase-NFAT5 pathway regulates macrophage activation and TLR-induced inflammatory arthritis.
Kim NH, Choi S, Han EJ, Hong BK, Choi SY, Kwon HM, Hwang SY, Cho CS, Kim WU. | 11/22/2014 |
| The expression and the activity of XO were increased dramatically within the central nervous system of experimental autoimmune encephalomyelitis mice as compared to naive mice. | Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.
Honorat JA, Kinoshita M, Okuno T, Takata K, Koda T, Tada S, Shirakura T, Fujimura H, Mochizuki H, Sakoda S, Nakatsuji Y., Free PMC Article | 05/3/2014 |